Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Polyglutamine (polyQ) diseases represent a group of progressive neurodegenerative disorders that are caused by abnormal expansion of CAG triplet nucleotides in disease genes. Recent evidence indicates that not only mutant polyQ proteins, but also their corresponding mutant RNAs, contribute to the pa...

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Bibliographic Details
Main Authors: Qian Zhang, Ho Tsoi, Shaohong Peng, Pan P. Li, Kwok-Fai Lau, Dobrila D. Rudnicki, Jacky Chi-Ki Ngo, Ho Yin Edwin Chan
Format: Article
Language:English
Published: The Company of Biologists 2016-03-01
Series:Disease Models & Mechanisms
Subjects:
Expanded-CAG RNA
Expanded-polyQ protein
Nucleolin
P3
Polyglutamine disease
QBP1
Spinocerebellar ataxia
Online Access:http://dmm.biologists.org/content/9/3/321

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