Impact of Perfect Drug Adherence on Immunopathogenic Mechanism for Dynamical System of Psoriasis
Psoriasis is a frequent autoimmune chronic skin disease differentiated by T-Cells agreeable hyperproliferation of epidermal Keratinocytes. The feature of TCells held up Psoriatic scratches is the epidermal penetration of basically oligoclonal CD8+ T-Cells and also of CD4+ T-Cells in the dermis. Psor...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bulgarian Academy of Sciences, Institute of Mathematics and Informatics
2013-01-01
|
| Series: | Biomath |
| Subjects: | |
| Online Access: | http://www.biomathforum.org/biomath/index.php/biomath/article/view/35 |
| _version_ | 1797716234724179968 |
|---|---|
| author | Priti Kumar Roy Abhirup Datta |
| author_facet | Priti Kumar Roy Abhirup Datta |
| author_sort | Priti Kumar Roy |
| collection | DOAJ |
| description | Psoriasis is a frequent autoimmune chronic skin disease differentiated by T-Cells agreeable hyperproliferation of epidermal Keratinocytes. The feature of TCells held up Psoriatic scratches is the epidermal penetration of basically oligoclonal CD8+ T-Cells and also of CD4+ T-Cells in the dermis. Psoriatic lesions are sharply distinguished, red and enlarged scratches together with whitish silver scales. In this research article, we propose a mathematical depiction for Psoriasis, involving a set of differential equations, regarding T-Cells, Dendritic Cells, CD8+ T-Cells and epidermal Keratinocytes. Here, we specially introduce the interaction between Dendritic Cells and CD8+ T-Cells to monitor the impact of this interaction upon the system dynamics. We also analyze the mathematical model both in presence and absence of effectiveness of two drugs. We study the system analytically and numerically to comprehend the significance of effectiveness of the drugs, integrated in the model system. Here, we reduce the Keratinocyte population to restrict Psoriasis by applying the combination of two drugs and able to enlighten the perspective of the disease dynamics for Psoriasis. |
| first_indexed | 2024-03-12T08:18:38Z |
| format | Article |
| id | doaj.art-2c997848726e4a1baa8913dd393e4a11 |
| institution | Directory Open Access Journal |
| issn | 1314-684X 1314-7218 |
| language | English |
| last_indexed | 2024-03-12T08:18:38Z |
| publishDate | 2013-01-01 |
| publisher | Bulgarian Academy of Sciences, Institute of Mathematics and Informatics |
| record_format | Article |
| series | Biomath |
| spelling | doaj.art-2c997848726e4a1baa8913dd393e4a112023-09-02T18:39:03ZengBulgarian Academy of Sciences, Institute of Mathematics and InformaticsBiomath1314-684X1314-72182013-01-012110.11145/j.biomath.2012.12.10145Impact of Perfect Drug Adherence on Immunopathogenic Mechanism for Dynamical System of PsoriasisPriti Kumar Roy0Abhirup Datta1Jadavpur UniversityJadavpur UniversityPsoriasis is a frequent autoimmune chronic skin disease differentiated by T-Cells agreeable hyperproliferation of epidermal Keratinocytes. The feature of TCells held up Psoriatic scratches is the epidermal penetration of basically oligoclonal CD8+ T-Cells and also of CD4+ T-Cells in the dermis. Psoriatic lesions are sharply distinguished, red and enlarged scratches together with whitish silver scales. In this research article, we propose a mathematical depiction for Psoriasis, involving a set of differential equations, regarding T-Cells, Dendritic Cells, CD8+ T-Cells and epidermal Keratinocytes. Here, we specially introduce the interaction between Dendritic Cells and CD8+ T-Cells to monitor the impact of this interaction upon the system dynamics. We also analyze the mathematical model both in presence and absence of effectiveness of two drugs. We study the system analytically and numerically to comprehend the significance of effectiveness of the drugs, integrated in the model system. Here, we reduce the Keratinocyte population to restrict Psoriasis by applying the combination of two drugs and able to enlighten the perspective of the disease dynamics for Psoriasis.http://www.biomathforum.org/biomath/index.php/biomath/article/view/35T-CellsDendritic CellsCD8+ T-CellsKeratinocytesMHCpMHCT-Cells ReceptorDermisEpidermisLymphocytesMonocytesNeutrophilsCytokinesDrug Efficacy. |
| spellingShingle | Priti Kumar Roy Abhirup Datta Impact of Perfect Drug Adherence on Immunopathogenic Mechanism for Dynamical System of Psoriasis Biomath T-Cells Dendritic Cells CD8+ T-Cells Keratinocytes MHC pMHC T-Cells Receptor Dermis Epidermis Lymphocytes Monocytes Neutrophils Cytokines Drug Efficacy. |
| title | Impact of Perfect Drug Adherence on Immunopathogenic Mechanism for Dynamical System of Psoriasis |
| title_full | Impact of Perfect Drug Adherence on Immunopathogenic Mechanism for Dynamical System of Psoriasis |
| title_fullStr | Impact of Perfect Drug Adherence on Immunopathogenic Mechanism for Dynamical System of Psoriasis |
| title_full_unstemmed | Impact of Perfect Drug Adherence on Immunopathogenic Mechanism for Dynamical System of Psoriasis |
| title_short | Impact of Perfect Drug Adherence on Immunopathogenic Mechanism for Dynamical System of Psoriasis |
| title_sort | impact of perfect drug adherence on immunopathogenic mechanism for dynamical system of psoriasis |
| topic | T-Cells Dendritic Cells CD8+ T-Cells Keratinocytes MHC pMHC T-Cells Receptor Dermis Epidermis Lymphocytes Monocytes Neutrophils Cytokines Drug Efficacy. |
| url | http://www.biomathforum.org/biomath/index.php/biomath/article/view/35 |
| work_keys_str_mv | AT pritikumarroy impactofperfectdrugadherenceonimmunopathogenicmechanismfordynamicalsystemofpsoriasis AT abhirupdatta impactofperfectdrugadherenceonimmunopathogenicmechanismfordynamicalsystemofpsoriasis |