Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatality
Tranylcypromine is an effective antidepressant from the class of monoamine oxidase inhibitors and is structurally related to amphetamine. However, reports differ regarding the potential metabolism of tranylcypromine to amphetamine and methamphetamine within the human body. We report a 25-year-old wo...
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Sultan Qaboos University
2017-05-01
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Series: | Sultan Qaboos University Medical Journal |
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Online Access: | https://journals.squ.edu.om/index.php/squmj/article/view/2209 |
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author | Maryam Akhgari Farzaneh Jokar Afshar Etemadi-Aleagha Ali Ghasemi |
author_facet | Maryam Akhgari Farzaneh Jokar Afshar Etemadi-Aleagha Ali Ghasemi |
author_sort | Maryam Akhgari |
collection | DOAJ |
description | Tranylcypromine is an effective antidepressant from the class of monoamine oxidase inhibitors and is structurally related to amphetamine. However, reports differ regarding the potential metabolism of tranylcypromine to amphetamine and methamphetamine within the human body. We report a 25-year-old woman with severe depression who died due to a fatal tranylcypromine overdose in 2016. She had been prescribed tranylcypromine one day previously and had no history of previous suicide attempts or substance abuse. The body was transferred to a forensic medicine department in Tehran, Iran for the autopsy. A urine sample was positive for tranylcypromine, amphetamine and methamphetamine using gas chromatography/mass spectrometry after derivatisation with heptafluorobutyric acid. As amphetamines were present in the urine sample, it was assumed that the tranylcypromine had been converted to amphetamines metabolically. As such, it is possible that the legitimate use of certain prescription drugs may complicate the interpretation of test results for illegal drugs. |
first_indexed | 2024-12-10T07:49:52Z |
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institution | Directory Open Access Journal |
issn | 2075-051X 2075-0528 |
language | English |
last_indexed | 2024-12-10T07:49:52Z |
publishDate | 2017-05-01 |
publisher | Sultan Qaboos University |
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series | Sultan Qaboos University Medical Journal |
spelling | doaj.art-2c9a593844ed4d00ae2548fa386463e02022-12-22T01:57:04ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal2075-051X2075-05282017-05-0117221321710.18295/squmj.2016.17.02.0132129Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatalityMaryam Akhgari0Farzaneh Jokar1Afshar Etemadi-Aleagha2Ali Ghasemi3Department of Forensic Toxicology, Legal Medicine Research Center, Legal Medicine Organization, Tehran, IranDepartment of Forensic Toxicology, Legal Medicine Research Center, Legal Medicine Organization, Tehran, IranDepartment of Anaesthesiology & Critical Care, Tehran University of Medical Sciences, Tehran, IranDepartment of Anaesthesiology & Critical Care, Tehran University of Medical Sciences, Tehran, IranTranylcypromine is an effective antidepressant from the class of monoamine oxidase inhibitors and is structurally related to amphetamine. However, reports differ regarding the potential metabolism of tranylcypromine to amphetamine and methamphetamine within the human body. We report a 25-year-old woman with severe depression who died due to a fatal tranylcypromine overdose in 2016. She had been prescribed tranylcypromine one day previously and had no history of previous suicide attempts or substance abuse. The body was transferred to a forensic medicine department in Tehran, Iran for the autopsy. A urine sample was positive for tranylcypromine, amphetamine and methamphetamine using gas chromatography/mass spectrometry after derivatisation with heptafluorobutyric acid. As amphetamines were present in the urine sample, it was assumed that the tranylcypromine had been converted to amphetamines metabolically. As such, it is possible that the legitimate use of certain prescription drugs may complicate the interpretation of test results for illegal drugs.https://journals.squ.edu.om/index.php/squmj/article/view/2209tranylcypromineamphetaminemetabolismforensic toxicologysubstance abuse detectioncase reportiran. |
spellingShingle | Maryam Akhgari Farzaneh Jokar Afshar Etemadi-Aleagha Ali Ghasemi Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatality Sultan Qaboos University Medical Journal tranylcypromine amphetamine metabolism forensic toxicology substance abuse detection case report iran. |
title | Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatality |
title_full | Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatality |
title_fullStr | Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatality |
title_full_unstemmed | Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatality |
title_short | Discrimination Between Drug Abuse and Medical Therapy : Case report of a tranylcypromine overdose-related fatality |
title_sort | discrimination between drug abuse and medical therapy case report of a tranylcypromine overdose related fatality |
topic | tranylcypromine amphetamine metabolism forensic toxicology substance abuse detection case report iran. |
url | https://journals.squ.edu.om/index.php/squmj/article/view/2209 |
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