Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint
<i>Background and Objectives</i>: The medial collateral ligament (MCL) is one of the major supporting ligaments of the knee joint, and MCL injuries are common where excessive valgus loading is applied to the knee joint. Although most MCL injuries can be treated conservatively, healing of...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/59/4/725 |
| _version_ | 1827744480696991744 |
|---|---|
| author | Chul-Soo Lee Ok-Hee Jeon Seung-Beom Han Ki-Mo Jang |
| author_facet | Chul-Soo Lee Ok-Hee Jeon Seung-Beom Han Ki-Mo Jang |
| author_sort | Chul-Soo Lee |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: The medial collateral ligament (MCL) is one of the major supporting ligaments of the knee joint, and MCL injuries are common where excessive valgus loading is applied to the knee joint. Although most MCL injuries can be treated conservatively, healing of the MCL can take several weeks to months. Furthermore, once injured, the biomechanical properties of the healed MCL differ from those of the native MCL, resulting in an increased risk of re-injury and chronic remnant symptoms. Mesenchymal stem cells (MSCs), owing to their therapeutic potential, have been investigated in various musculoskeletal injuries, and some preclinical studies regarding MSC-based approaches in MCL injuries have shown promising results. Despite satisfactory results in preclinical studies, there is still a lack of clinical studies in the orthopedic literature. This article describes the basic knowledge of the MCL, standard treatments for MCL injuries, and recent studies regarding the application of MSCs for enhanced healing of the MCL. MSC-based approaches are expected to be a potential therapeutic option for enhanced healing of the MCL in the future. |
| first_indexed | 2024-03-11T04:45:27Z |
| format | Article |
| id | doaj.art-2c9b497e92a644deb336c2436ba57a62 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T04:45:27Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-2c9b497e92a644deb336c2436ba57a622023-11-17T20:21:07ZengMDPI AGMedicina1010-660X1648-91442023-04-0159472510.3390/medicina59040725Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee JointChul-Soo Lee0Ok-Hee Jeon1Seung-Beom Han2Ki-Mo Jang3Department of Orthopaedic Surgery, Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of KoreaDepartment of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Republic of KoreaDepartment of Orthopaedic Surgery, Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of KoreaDepartment of Orthopaedic Surgery, Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea<i>Background and Objectives</i>: The medial collateral ligament (MCL) is one of the major supporting ligaments of the knee joint, and MCL injuries are common where excessive valgus loading is applied to the knee joint. Although most MCL injuries can be treated conservatively, healing of the MCL can take several weeks to months. Furthermore, once injured, the biomechanical properties of the healed MCL differ from those of the native MCL, resulting in an increased risk of re-injury and chronic remnant symptoms. Mesenchymal stem cells (MSCs), owing to their therapeutic potential, have been investigated in various musculoskeletal injuries, and some preclinical studies regarding MSC-based approaches in MCL injuries have shown promising results. Despite satisfactory results in preclinical studies, there is still a lack of clinical studies in the orthopedic literature. This article describes the basic knowledge of the MCL, standard treatments for MCL injuries, and recent studies regarding the application of MSCs for enhanced healing of the MCL. MSC-based approaches are expected to be a potential therapeutic option for enhanced healing of the MCL in the future.https://www.mdpi.com/1648-9144/59/4/725knee jointligamentligament healingmedial collateral ligamentcell-based treatmentmesenchymal stem cell |
| spellingShingle | Chul-Soo Lee Ok-Hee Jeon Seung-Beom Han Ki-Mo Jang Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint Medicina knee joint ligament ligament healing medial collateral ligament cell-based treatment mesenchymal stem cell |
| title | Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint |
| title_full | Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint |
| title_fullStr | Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint |
| title_full_unstemmed | Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint |
| title_short | Mesenchymal Stem Cells for Enhanced Healing of the Medial Collateral Ligament of the Knee Joint |
| title_sort | mesenchymal stem cells for enhanced healing of the medial collateral ligament of the knee joint |
| topic | knee joint ligament ligament healing medial collateral ligament cell-based treatment mesenchymal stem cell |
| url | https://www.mdpi.com/1648-9144/59/4/725 |
| work_keys_str_mv | AT chulsoolee mesenchymalstemcellsforenhancedhealingofthemedialcollateralligamentofthekneejoint AT okheejeon mesenchymalstemcellsforenhancedhealingofthemedialcollateralligamentofthekneejoint AT seungbeomhan mesenchymalstemcellsforenhancedhealingofthemedialcollateralligamentofthekneejoint AT kimojang mesenchymalstemcellsforenhancedhealingofthemedialcollateralligamentofthekneejoint |