Repurposing of Drugs Targeting YAP-TEAD Functions
Drug repurposing is a fast and consolidated approach for the research of new active compounds bypassing the long streamline of the drug discovery process. Several drugs in clinical practice have been reported for modulating the major Hippo pathway’s terminal effectors, namely YAP (Yes1-ass...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/10/9/329 |
| _version_ | 1797706372493606912 |
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| author | Gian Marco Elisi Matteo Santucci Domenico D’Arca Angela Lauriola Gaetano Marverti Lorena Losi Laura Scalvini Maria Laura Bolognesi Marco Mor Maria Paola Costi |
| author_facet | Gian Marco Elisi Matteo Santucci Domenico D’Arca Angela Lauriola Gaetano Marverti Lorena Losi Laura Scalvini Maria Laura Bolognesi Marco Mor Maria Paola Costi |
| author_sort | Gian Marco Elisi |
| collection | DOAJ |
| description | Drug repurposing is a fast and consolidated approach for the research of new active compounds bypassing the long streamline of the drug discovery process. Several drugs in clinical practice have been reported for modulating the major Hippo pathway’s terminal effectors, namely YAP (Yes1-associated protein), TAZ (transcriptional co-activator with PDZ-binding motif) and TEAD (transcriptional enhanced associate domains), which are directly involved in the regulation of cell growth and tissue homeostasis. Since this pathway is known to have many cross-talking phenomena with cell signaling pathways, many efforts have been made to understand its importance in oncology. Moreover, this could be relevant to obtain new molecular tools and potential therapeutic assets. In this review, we discuss the main mechanisms of action of the best-known compounds, clinically approved or investigational drugs, able to cross-talk and modulate the Hippo pathway, as an attractive strategy for the discovery of new potential lead compounds. |
| first_indexed | 2024-03-12T05:51:14Z |
| format | Article |
| id | doaj.art-2ca0037b9f14465aad6d1166453ae321 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T05:51:14Z |
| publishDate | 2018-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-2ca0037b9f14465aad6d1166453ae3212023-09-03T05:05:58ZengMDPI AGCancers2072-66942018-09-0110932910.3390/cancers10090329cancers10090329Repurposing of Drugs Targeting YAP-TEAD FunctionsGian Marco Elisi0Matteo Santucci1Domenico D’Arca2Angela Lauriola3Gaetano Marverti4Lorena Losi5Laura Scalvini6Maria Laura Bolognesi7Marco Mor8Maria Paola Costi9Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, Unit of Pathology, 41124 Modena, ItalyDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, ItalyDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum, University of Bologna, 40126 Bologna, ItalyDipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parco Area delle Scienze 27/A, 43124 Parma, ItalyDepartment of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, ItalyDrug repurposing is a fast and consolidated approach for the research of new active compounds bypassing the long streamline of the drug discovery process. Several drugs in clinical practice have been reported for modulating the major Hippo pathway’s terminal effectors, namely YAP (Yes1-associated protein), TAZ (transcriptional co-activator with PDZ-binding motif) and TEAD (transcriptional enhanced associate domains), which are directly involved in the regulation of cell growth and tissue homeostasis. Since this pathway is known to have many cross-talking phenomena with cell signaling pathways, many efforts have been made to understand its importance in oncology. Moreover, this could be relevant to obtain new molecular tools and potential therapeutic assets. In this review, we discuss the main mechanisms of action of the best-known compounds, clinically approved or investigational drugs, able to cross-talk and modulate the Hippo pathway, as an attractive strategy for the discovery of new potential lead compounds.http://www.mdpi.com/2072-6694/10/9/329Hippo pathwayYAP-TEAD disruptiondrug repurposingcell signalingprotein-protein interactions |
| spellingShingle | Gian Marco Elisi Matteo Santucci Domenico D’Arca Angela Lauriola Gaetano Marverti Lorena Losi Laura Scalvini Maria Laura Bolognesi Marco Mor Maria Paola Costi Repurposing of Drugs Targeting YAP-TEAD Functions Cancers Hippo pathway YAP-TEAD disruption drug repurposing cell signaling protein-protein interactions |
| title | Repurposing of Drugs Targeting YAP-TEAD Functions |
| title_full | Repurposing of Drugs Targeting YAP-TEAD Functions |
| title_fullStr | Repurposing of Drugs Targeting YAP-TEAD Functions |
| title_full_unstemmed | Repurposing of Drugs Targeting YAP-TEAD Functions |
| title_short | Repurposing of Drugs Targeting YAP-TEAD Functions |
| title_sort | repurposing of drugs targeting yap tead functions |
| topic | Hippo pathway YAP-TEAD disruption drug repurposing cell signaling protein-protein interactions |
| url | http://www.mdpi.com/2072-6694/10/9/329 |
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