Repurposing of Drugs Targeting YAP-TEAD Functions

Repurposing of Drugs Targeting YAP-TEAD Functions

Drug repurposing is a fast and consolidated approach for the research of new active compounds bypassing the long streamline of the drug discovery process. Several drugs in clinical practice have been reported for modulating the major Hippo pathway’s terminal effectors, namely YAP (Yes1-ass...

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Bibliographic Details
Main Authors: Gian Marco Elisi, Matteo Santucci, Domenico D’Arca, Angela Lauriola, Gaetano Marverti, Lorena Losi, Laura Scalvini, Maria Laura Bolognesi, Marco Mor, Maria Paola Costi
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
Hippo pathway
YAP-TEAD disruption
drug repurposing
cell signaling
protein-protein interactions
Online Access:http://www.mdpi.com/2072-6694/10/9/329

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