Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models
Type 2 diabetes often presents with reproductive disorders, including reduced male and female fertility. Here they show that diabetes disrupts the APLN signaling axis in the testes and that spermatogenesis can be restored through treatment with an APLN antagonist.
Bibliographic Details
| Main Authors: |
Ke Song,
Xinyan Yang,
Geng An,
Xinyu Xia,
Jiexiang Zhao,
Xiaoheng Xu,
Cong Wan,
Tianyuan Liu,
Yi Zheng,
Shaofang Ren,
Mei Wang,
Gang Chang,
Shane J. F. Cronin,
Josef M. Penninger,
Tao Jing,
Xianghong Ou,
Shuan Rao,
Zhaoting Liu,
Xiao-Yang Zhao |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-34990-3
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