Is netrin-1 a reliable inflammatory marker for periodontitis?
Background. The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease. Methods. Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontal...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2022-06-01
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| Series: | Journal of Advanced Periodontology and Implant Dentistry |
| Subjects: | |
| Online Access: | https://japid.tbzmed.ac.ir/PDF/japid-14-1.pdf |
| _version_ | 1818469528945819648 |
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| author | Sarah Yasser Abdulfattah Azza Abdel Baky Baiomy Jilan Mohammed Youssef |
| author_facet | Sarah Yasser Abdulfattah Azza Abdel Baky Baiomy Jilan Mohammed Youssef |
| author_sort | Sarah Yasser Abdulfattah |
| collection | DOAJ |
| description | Background. The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease. Methods. Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy. Whole-mouth periodontal parameters [probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI)] were recorded. The GCF samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (SRP) in the periodontitis group. Results. Netrin-1 GCF levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin-1 GCF levels after SRP (P<0.05). Conclusion. Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease. |
| first_indexed | 2024-04-13T21:24:50Z |
| format | Article |
| id | doaj.art-2ca135f1464440c7bf8f0a5139c3b8d1 |
| institution | Directory Open Access Journal |
| issn | 2645-5390 |
| language | English |
| last_indexed | 2024-04-13T21:24:50Z |
| publishDate | 2022-06-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Periodontology and Implant Dentistry |
| spelling | doaj.art-2ca135f1464440c7bf8f0a5139c3b8d12022-12-22T02:29:21ZengTabriz University of Medical SciencesJournal of Advanced Periodontology and Implant Dentistry2645-53902022-06-011411610.34172/japid.2022.001japid-1170Is netrin-1 a reliable inflammatory marker for periodontitis?Sarah Yasser Abdulfattah0Azza Abdel Baky Baiomy1Jilan Mohammed Youssef2Department of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, EgyptDepartment of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, EgyptDepartment of Oral Medicine, Periodontology, Diagnosis and Oral Radiology, Faculty of Dentistry, Mansoura University, Mansoura, EgyptBackground. The current study tested netrin-1 as a reliable inflammatory marker of periodontal disease. Methods. Gingival crevicular fluid (GCF) samples were taken at baseline from 30 systemically healthy individuals. Fifteen subjects had stage II grade A or B periodontitis, and 15 were periodontally and clinically healthy. Whole-mouth periodontal parameters [probing depth (PD), clinical attachment loss (CAL), plaque index (PI), and gingival index (GI)] were recorded. The GCF samples were re-collected, and clinical parameters were re-recorded after six weeks following full-mouth scaling and root planing (SRP) in the periodontitis group. Results. Netrin-1 GCF levels were significantly lower in periodontitis patients than periodontally healthy individuals at baseline with a significant increase in netrin-1 GCF levels after SRP (P<0.05). Conclusion. Netrin-1 may have a significant role in the inflammatory process of chronic periodontitis; thus, it could be a promising anti-inflammatory marker in periodontal disease.https://japid.tbzmed.ac.ir/PDF/japid-14-1.pdfgingival crevicular fluidhost responseinflammationnetrin-1periodontitisscaling and root planing |
| spellingShingle | Sarah Yasser Abdulfattah Azza Abdel Baky Baiomy Jilan Mohammed Youssef Is netrin-1 a reliable inflammatory marker for periodontitis? Journal of Advanced Periodontology and Implant Dentistry gingival crevicular fluid host response inflammation netrin-1 periodontitis scaling and root planing |
| title | Is netrin-1 a reliable inflammatory marker for periodontitis? |
| title_full | Is netrin-1 a reliable inflammatory marker for periodontitis? |
| title_fullStr | Is netrin-1 a reliable inflammatory marker for periodontitis? |
| title_full_unstemmed | Is netrin-1 a reliable inflammatory marker for periodontitis? |
| title_short | Is netrin-1 a reliable inflammatory marker for periodontitis? |
| title_sort | is netrin 1 a reliable inflammatory marker for periodontitis |
| topic | gingival crevicular fluid host response inflammation netrin-1 periodontitis scaling and root planing |
| url | https://japid.tbzmed.ac.ir/PDF/japid-14-1.pdf |
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