The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases
Here, we review the haloacid dehalogenase (HAD) class of protein phosphatases, with a particular emphasis on an unusual group of enzymes, the eyes absent (EYA) family. EYA proteins have the unique distinction of being structurally and mechanistically classified as HAD enzymes, yet, unlike other HAD...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/8/3925 |
| _version_ | 1797538111104745472 |
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| author | Kaushik Roychoudhury Rashmi S. Hegde |
| author_facet | Kaushik Roychoudhury Rashmi S. Hegde |
| author_sort | Kaushik Roychoudhury |
| collection | DOAJ |
| description | Here, we review the haloacid dehalogenase (HAD) class of protein phosphatases, with a particular emphasis on an unusual group of enzymes, the eyes absent (EYA) family. EYA proteins have the unique distinction of being structurally and mechanistically classified as HAD enzymes, yet, unlike other HAD phosphatases, they are protein tyrosine phosphatases (PTPs). Further, the EYA proteins are unique among the 107 classical PTPs in the human genome because they do not use a Cysteine residue as a nucleophile in the dephosphorylation reaction. We will provide an overview of HAD phosphatase structure-function, describe unique features of the EYA family and their tyrosine phosphatase activity, provide a brief summary of the known substrates and cellular functions of the EYA proteins, and speculate about the evolutionary origins of the EYA family of proteins. |
| first_indexed | 2024-03-10T12:25:51Z |
| format | Article |
| id | doaj.art-2ca1baad1cdd461d8260d2ebb60511d5 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T12:25:51Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2ca1baad1cdd461d8260d2ebb60511d52023-11-21T15:00:36ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-04-01228392510.3390/ijms22083925The Eyes Absent Proteins: Unusual HAD Family Tyrosine PhosphatasesKaushik Roychoudhury0Rashmi S. Hegde1Division of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USADivision of Developmental Biology, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USAHere, we review the haloacid dehalogenase (HAD) class of protein phosphatases, with a particular emphasis on an unusual group of enzymes, the eyes absent (EYA) family. EYA proteins have the unique distinction of being structurally and mechanistically classified as HAD enzymes, yet, unlike other HAD phosphatases, they are protein tyrosine phosphatases (PTPs). Further, the EYA proteins are unique among the 107 classical PTPs in the human genome because they do not use a Cysteine residue as a nucleophile in the dephosphorylation reaction. We will provide an overview of HAD phosphatase structure-function, describe unique features of the EYA family and their tyrosine phosphatase activity, provide a brief summary of the known substrates and cellular functions of the EYA proteins, and speculate about the evolutionary origins of the EYA family of proteins.https://www.mdpi.com/1422-0067/22/8/3925HADeyes absentEYA1EYA2EYA3EYA4 |
| spellingShingle | Kaushik Roychoudhury Rashmi S. Hegde The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases International Journal of Molecular Sciences HAD eyes absent EYA1 EYA2 EYA3 EYA4 |
| title | The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases |
| title_full | The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases |
| title_fullStr | The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases |
| title_full_unstemmed | The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases |
| title_short | The Eyes Absent Proteins: Unusual HAD Family Tyrosine Phosphatases |
| title_sort | eyes absent proteins unusual had family tyrosine phosphatases |
| topic | HAD eyes absent EYA1 EYA2 EYA3 EYA4 |
| url | https://www.mdpi.com/1422-0067/22/8/3925 |
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