Do 2‐year changes in superior frontal gyrus and global brain atrophy affect cognition?
Abstract Introduction Metabolic alterations to the superior frontal gyrus (SFG) have been linked to cognitive decline. Whether these indicate structural atrophy, which could be screened for at a larger scale using noninvasive structural imaging, is unknown. Methods We assessed annual structural magn...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2018.07.010 |
| _version_ | 1819091716575068160 |
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| author | Maria del C. Valdés Hernández Stuart Reid Shadia Mikhael Cyril Pernet The Alzheimer's Disease Neuroimaging Initiative |
| author_facet | Maria del C. Valdés Hernández Stuart Reid Shadia Mikhael Cyril Pernet The Alzheimer's Disease Neuroimaging Initiative |
| author_sort | Maria del C. Valdés Hernández |
| collection | DOAJ |
| description | Abstract Introduction Metabolic alterations to the superior frontal gyrus (SFG) have been linked to cognitive decline. Whether these indicate structural atrophy, which could be screened for at a larger scale using noninvasive structural imaging, is unknown. Methods We assessed annual structural magnetic resonance imaging scans and cognitive data from 3 consecutive years from 204 participants from the AD Neuroimaging Initiative database (mean age 72.24 [8.175] years). We evaluated associations between brain structural changes and performance in the Montreal Cognitive Assessment, Everyday Cognition Visuospatial subtest (ECog Visuospatial), and Functional Assessment Questionnaire. Results Changes in the surface area of the SFG were associated with changes in the outcome of the ECog Visuospatial test (P < .05), but an inconsistent pattern of association was found between the 2‐year global brain atrophy progression and changes in the outcome from the three cognitive tests selected. Discussion The extent into which (and if) changes in the SFG influence cognition warrant further evaluation in a larger period in more heterogeneous population. |
| first_indexed | 2024-12-21T22:44:09Z |
| format | Article |
| id | doaj.art-2ca2d0c67a644067b7bf20581df7ecb0 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-12-21T22:44:09Z |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-2ca2d0c67a644067b7bf20581df7ecb02022-12-21T18:47:45ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292018-01-0110170671610.1016/j.dadm.2018.07.010Do 2‐year changes in superior frontal gyrus and global brain atrophy affect cognition?Maria del C. Valdés Hernández0Stuart Reid1Shadia Mikhael2Cyril Pernet3The Alzheimer's Disease Neuroimaging Initiative4Department of Neuroimaging Sciences, Centre for Clinical Brain SciencesUniversity of EdinburghEdinburghUKCollege of Medicine and Veterinary Medicine, University of EdinburghEdinburghUKDepartment of Neuroimaging Sciences, Centre for Clinical Brain SciencesUniversity of EdinburghEdinburghUKDepartment of Neuroimaging Sciences, Centre for Clinical Brain SciencesUniversity of EdinburghEdinburghUKDepartment of Neuroimaging Sciences, Centre for Clinical Brain SciencesUniversity of EdinburghEdinburghUKAbstract Introduction Metabolic alterations to the superior frontal gyrus (SFG) have been linked to cognitive decline. Whether these indicate structural atrophy, which could be screened for at a larger scale using noninvasive structural imaging, is unknown. Methods We assessed annual structural magnetic resonance imaging scans and cognitive data from 3 consecutive years from 204 participants from the AD Neuroimaging Initiative database (mean age 72.24 [8.175] years). We evaluated associations between brain structural changes and performance in the Montreal Cognitive Assessment, Everyday Cognition Visuospatial subtest (ECog Visuospatial), and Functional Assessment Questionnaire. Results Changes in the surface area of the SFG were associated with changes in the outcome of the ECog Visuospatial test (P < .05), but an inconsistent pattern of association was found between the 2‐year global brain atrophy progression and changes in the outcome from the three cognitive tests selected. Discussion The extent into which (and if) changes in the SFG influence cognition warrant further evaluation in a larger period in more heterogeneous population.https://doi.org/10.1016/j.dadm.2018.07.010BrainMRISuperior frontal gyrusBrain atrophyCognitive decline |
| spellingShingle | Maria del C. Valdés Hernández Stuart Reid Shadia Mikhael Cyril Pernet The Alzheimer's Disease Neuroimaging Initiative Do 2‐year changes in superior frontal gyrus and global brain atrophy affect cognition? Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Brain MRI Superior frontal gyrus Brain atrophy Cognitive decline |
| title | Do 2‐year changes in superior frontal gyrus and global brain atrophy affect cognition? |
| title_full | Do 2‐year changes in superior frontal gyrus and global brain atrophy affect cognition? |
| title_fullStr | Do 2‐year changes in superior frontal gyrus and global brain atrophy affect cognition? |
| title_full_unstemmed | Do 2‐year changes in superior frontal gyrus and global brain atrophy affect cognition? |
| title_short | Do 2‐year changes in superior frontal gyrus and global brain atrophy affect cognition? |
| title_sort | do 2 year changes in superior frontal gyrus and global brain atrophy affect cognition |
| topic | Brain MRI Superior frontal gyrus Brain atrophy Cognitive decline |
| url | https://doi.org/10.1016/j.dadm.2018.07.010 |
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