An overview of the pathogenic mechanisms of autoimmune thyroid disorders
Abstract Objectives, recent epidemiologic studies in humans suggest an increased prevalence of thyroiditis associated with the excessive administration of iodine. More than three times of recommended daily intake of iodine was observed among people in North America. These people generally presented...
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| Format: | Article |
| Language: | English |
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Kosin University College of Medicine
2014-12-01
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| Series: | Kosin Medical Journal |
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| Online Access: | http://www.kosinmedj.org/upload/pdf/ksmc029-02-01.pdf |
| _version_ | 1811192718301331456 |
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| author | Keun Yong Park |
| author_facet | Keun Yong Park |
| author_sort | Keun Yong Park |
| collection | DOAJ |
| description | Abstract Objectives, recent epidemiologic studies in humans suggest an increased prevalence of thyroiditis associated with the excessive administration of iodine. More than three times of recommended daily intake of iodine was observed among people in North America. These people generally presented higher level of anti-thyroglobulin antibody, anti-thyroperoxidase antibody, serum thyroid-stimulating hormone and exacerbation of lymphocytic infiltration in thyroid, which indicated the overconsumption of iodine could induce hypothyroidism and enhance the autoimmune response. However, the precise mechanism of excessive iodine intake induced autoimmune thyroid disease remains largely unknown. Over half a century has elapsed since the 1956 identification of thyroglobulin antibodies and the devising of the first experimental model of autoimmune thyroiditis. Since then an incredible amount of experimental work has led to an ever deeper understanding of the nature of thyroid auto-antigens, the main immune mechanisms responsible for Hashimoto's thyroiditis and graves’ disease, their genetics, and therir environmental risk factor. Yet, in the majority of genetically predisposed people the individual trigger of thyroid autoimmunity remains obscure. Similarly, effective prevention strategies still remain to be established and, hopefully, will be the target of future studies. |
| first_indexed | 2024-04-11T23:56:04Z |
| format | Article |
| id | doaj.art-2ca411e83764493cb6ee9a5b20396bbc |
| institution | Directory Open Access Journal |
| issn | 2005-9531 2586-7024 |
| language | English |
| last_indexed | 2024-04-11T23:56:04Z |
| publishDate | 2014-12-01 |
| publisher | Kosin University College of Medicine |
| record_format | Article |
| series | Kosin Medical Journal |
| spelling | doaj.art-2ca411e83764493cb6ee9a5b20396bbc2022-12-22T03:56:21ZengKosin University College of MedicineKosin Medical Journal2005-95312586-70242014-12-01292939810.7180/kmj.2014.29.2.93155An overview of the pathogenic mechanisms of autoimmune thyroid disordersKeun Yong Park0Department of Internal Medicine, College of Medicine, Konyang University, Daejeon, KoreaAbstract Objectives, recent epidemiologic studies in humans suggest an increased prevalence of thyroiditis associated with the excessive administration of iodine. More than three times of recommended daily intake of iodine was observed among people in North America. These people generally presented higher level of anti-thyroglobulin antibody, anti-thyroperoxidase antibody, serum thyroid-stimulating hormone and exacerbation of lymphocytic infiltration in thyroid, which indicated the overconsumption of iodine could induce hypothyroidism and enhance the autoimmune response. However, the precise mechanism of excessive iodine intake induced autoimmune thyroid disease remains largely unknown. Over half a century has elapsed since the 1956 identification of thyroglobulin antibodies and the devising of the first experimental model of autoimmune thyroiditis. Since then an incredible amount of experimental work has led to an ever deeper understanding of the nature of thyroid auto-antigens, the main immune mechanisms responsible for Hashimoto's thyroiditis and graves’ disease, their genetics, and therir environmental risk factor. Yet, in the majority of genetically predisposed people the individual trigger of thyroid autoimmunity remains obscure. Similarly, effective prevention strategies still remain to be established and, hopefully, will be the target of future studies.http://www.kosinmedj.org/upload/pdf/ksmc029-02-01.pdfautoimmunepathogenic mechanismthyroid disorders |
| spellingShingle | Keun Yong Park An overview of the pathogenic mechanisms of autoimmune thyroid disorders Kosin Medical Journal autoimmune pathogenic mechanism thyroid disorders |
| title | An overview of the pathogenic mechanisms of autoimmune thyroid disorders |
| title_full | An overview of the pathogenic mechanisms of autoimmune thyroid disorders |
| title_fullStr | An overview of the pathogenic mechanisms of autoimmune thyroid disorders |
| title_full_unstemmed | An overview of the pathogenic mechanisms of autoimmune thyroid disorders |
| title_short | An overview of the pathogenic mechanisms of autoimmune thyroid disorders |
| title_sort | overview of the pathogenic mechanisms of autoimmune thyroid disorders |
| topic | autoimmune pathogenic mechanism thyroid disorders |
| url | http://www.kosinmedj.org/upload/pdf/ksmc029-02-01.pdf |
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