Crocetin Protected Human Hepatocyte LO2 Cell From TGF-β-Induced Oxygen Stress and Apoptosis but Promoted Proliferation and Autophagy via AMPK/m-TOR Pathway
ObjectiveTo investigate the protective effects of crocetin against transforming growth factor-β (TGF-β)—induced injury in LO2 cells.MethodsHuman hepatocyte LO2 cells were pre-treated with crocetin (10 μM) for 6, 12, and 24 h, and then induced by TGF-β. Proliferation, oxidative stress, apoptosis, aut...
Main Authors: | Hongxing Guo, Chenyu Ruan, Xiuhong Zhan, Hao Pan, Yumei Luo, Ke Gao |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-06-01
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Series: | Frontiers in Public Health |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.909125/full |
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