Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review

Background/objectivesImmune-inflammatory changes have been found in all types of suicidal ideation and behavior (SIB), independently of associated mental disorders. Since several Single Nucleotide Polymorphisms (SNPs) affect the function of inflammation-related genes, we searched the literature for...

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Main Authors: Rabah Tamimou, Serge Lumbroso, Kevin Mouzat, Jorge Lopez-Castroman
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Psychiatry
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1003034/full
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author Rabah Tamimou
Rabah Tamimou
Rabah Tamimou
Serge Lumbroso
Kevin Mouzat
Jorge Lopez-Castroman
Jorge Lopez-Castroman
Jorge Lopez-Castroman
author_facet Rabah Tamimou
Rabah Tamimou
Rabah Tamimou
Serge Lumbroso
Kevin Mouzat
Jorge Lopez-Castroman
Jorge Lopez-Castroman
Jorge Lopez-Castroman
author_sort Rabah Tamimou
collection DOAJ
description Background/objectivesImmune-inflammatory changes have been found in all types of suicidal ideation and behavior (SIB), independently of associated mental disorders. Since several Single Nucleotide Polymorphisms (SNPs) affect the function of inflammation-related genes, we searched the literature for genetic variations potentially altering inflammatory processes in SIB.MethodsWe included studies that looked for associations between SIB and SNPs in genes related to inflammatory processes. Case reports, literature reviews, and animal studies were excluded. Articles were retrieved from PubMed and PsycINFO databases, Google Scholar and GreySource Index until September 17th, 2022. Quality was assessed using Q-Genie.ResultsWe analyzed 32 studies. SIB has been associated with eighteen SNPs located in genes encoding for interleukin-8 (rs4073), C-reactive protein (rs1130864), tumor necrosis factor α (rs1800629, rs361525, and rs1099724), tumor necrosis factor receptor 2 (rs1061622), transforming growth factor β-1 (rs1982073), acid phosphatase 1 (rs7419262, rs300774), interleukin-10 (rs1800896), interferon γ (rs2430561), amino-carboxy muconate semialdehyde decarboxylase (rs2121337), interleukin 7 (rs10448044, rs10448042), macrophage migration inhibitory factor (rs755622), interleukin 1-α (rs1800587), and interleukin 1-β (rs1143634 and rs16944. A genome-wide association study reported one association at the threshold of significance with the rs300774 SNP, located in the 2p25 region containing ACP1 gene.DiscussionThe studies included were methodologically and clinically diverse and of moderate quality. Their findings suggest that some inflammation-related SNPs could increase the likelihood of SIB but the evidence to date is insufficient. Further research using gene-gene (GxG) and gene-environment (GxE) approaches is warranted.Systematic review registration[https://www.crd.york.ac.uk], identifier [CRD42022296310].
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spelling doaj.art-2ca8e88a7c64468a878427e01b99c6882022-12-22T04:06:44ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-10-011310.3389/fpsyt.2022.10030341003034Genetic variations related to inflammation in suicidal ideation and behavior: A systematic reviewRabah Tamimou0Rabah Tamimou1Rabah Tamimou2Serge Lumbroso3Kevin Mouzat4Jorge Lopez-Castroman5Jorge Lopez-Castroman6Jorge Lopez-Castroman7Department of Psychiatry, Nimes University Hospital, Nimes, FranceLaboratory of Biochemistry and Molecular Biology, Nimes University Hospital, University of Montpellier, Nimes, FranceInstitut de Génomique Fonctionnelle, University of Montpellier, CNRS-INSERM, Montpellier, FranceLaboratory of Biochemistry and Molecular Biology, Nimes University Hospital, University of Montpellier, Nimes, FranceLaboratory of Biochemistry and Molecular Biology, Nimes University Hospital, University of Montpellier, Nimes, FranceDepartment of Psychiatry, Nimes University Hospital, Nimes, FranceInstitut de Génomique Fonctionnelle, University of Montpellier, CNRS-INSERM, Montpellier, FranceCentro de Investigación Biomédica en Red de Salud Mental, Madrid, SpainBackground/objectivesImmune-inflammatory changes have been found in all types of suicidal ideation and behavior (SIB), independently of associated mental disorders. Since several Single Nucleotide Polymorphisms (SNPs) affect the function of inflammation-related genes, we searched the literature for genetic variations potentially altering inflammatory processes in SIB.MethodsWe included studies that looked for associations between SIB and SNPs in genes related to inflammatory processes. Case reports, literature reviews, and animal studies were excluded. Articles were retrieved from PubMed and PsycINFO databases, Google Scholar and GreySource Index until September 17th, 2022. Quality was assessed using Q-Genie.ResultsWe analyzed 32 studies. SIB has been associated with eighteen SNPs located in genes encoding for interleukin-8 (rs4073), C-reactive protein (rs1130864), tumor necrosis factor α (rs1800629, rs361525, and rs1099724), tumor necrosis factor receptor 2 (rs1061622), transforming growth factor β-1 (rs1982073), acid phosphatase 1 (rs7419262, rs300774), interleukin-10 (rs1800896), interferon γ (rs2430561), amino-carboxy muconate semialdehyde decarboxylase (rs2121337), interleukin 7 (rs10448044, rs10448042), macrophage migration inhibitory factor (rs755622), interleukin 1-α (rs1800587), and interleukin 1-β (rs1143634 and rs16944. A genome-wide association study reported one association at the threshold of significance with the rs300774 SNP, located in the 2p25 region containing ACP1 gene.DiscussionThe studies included were methodologically and clinically diverse and of moderate quality. Their findings suggest that some inflammation-related SNPs could increase the likelihood of SIB but the evidence to date is insufficient. Further research using gene-gene (GxG) and gene-environment (GxE) approaches is warranted.Systematic review registration[https://www.crd.york.ac.uk], identifier [CRD42022296310].https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1003034/fullself-injurious behaviorsuicidepolymorphismSNPcytokineschemokines
spellingShingle Rabah Tamimou
Rabah Tamimou
Rabah Tamimou
Serge Lumbroso
Kevin Mouzat
Jorge Lopez-Castroman
Jorge Lopez-Castroman
Jorge Lopez-Castroman
Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review
Frontiers in Psychiatry
self-injurious behavior
suicide
polymorphism
SNP
cytokines
chemokines
title Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review
title_full Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review
title_fullStr Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review
title_full_unstemmed Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review
title_short Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review
title_sort genetic variations related to inflammation in suicidal ideation and behavior a systematic review
topic self-injurious behavior
suicide
polymorphism
SNP
cytokines
chemokines
url https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1003034/full
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