Phospholipid Membrane Transport and Associated Diseases
Phospholipids are the basic structure block of eukaryotic membranes, in both the outer and inner membranes, which delimit cell organelles. Phospholipids can also be damaged by oxidative stress produced by mitochondria, for instance, becoming oxidized phospholipids. These damaged phospholipids have b...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/1201 |
| _version_ | 1797501292795396096 |
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| author | Raúl Ventura Inma Martínez-Ruiz María Isabel Hernández-Alvarez |
| author_facet | Raúl Ventura Inma Martínez-Ruiz María Isabel Hernández-Alvarez |
| author_sort | Raúl Ventura |
| collection | DOAJ |
| description | Phospholipids are the basic structure block of eukaryotic membranes, in both the outer and inner membranes, which delimit cell organelles. Phospholipids can also be damaged by oxidative stress produced by mitochondria, for instance, becoming oxidized phospholipids. These damaged phospholipids have been related to prevalent diseases such as atherosclerosis or non-alcoholic steatohepatitis (NASH) because they alter gene expression and induce cellular stress and apoptosis. One of the main sites of phospholipid synthesis is the endoplasmic reticulum (ER). ER association with other organelles through membrane contact sites (MCS) provides a close apposition for lipid transport. Additionally, an important advance in this small cytosolic gap are lipid transfer proteins (LTPs), which accelerate and modulate the distribution of phospholipids in other organelles. In this regard, LTPs can be established as an essential point within phospholipid circulation, as relevant data show impaired phospholipid transport when LTPs are defected. This review will focus on phospholipid function, metabolism, non-vesicular transport, and associated diseases. |
| first_indexed | 2024-03-10T03:16:18Z |
| format | Article |
| id | doaj.art-2caacc0aec40408a8fbfbd8acec2c5a0 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:16:18Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-2caacc0aec40408a8fbfbd8acec2c5a02023-11-23T10:12:31ZengMDPI AGBiomedicines2227-90592022-05-01105120110.3390/biomedicines10051201Phospholipid Membrane Transport and Associated DiseasesRaúl Ventura0Inma Martínez-Ruiz1María Isabel Hernández-Alvarez2Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, SpainDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, SpainDepartament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, SpainPhospholipids are the basic structure block of eukaryotic membranes, in both the outer and inner membranes, which delimit cell organelles. Phospholipids can also be damaged by oxidative stress produced by mitochondria, for instance, becoming oxidized phospholipids. These damaged phospholipids have been related to prevalent diseases such as atherosclerosis or non-alcoholic steatohepatitis (NASH) because they alter gene expression and induce cellular stress and apoptosis. One of the main sites of phospholipid synthesis is the endoplasmic reticulum (ER). ER association with other organelles through membrane contact sites (MCS) provides a close apposition for lipid transport. Additionally, an important advance in this small cytosolic gap are lipid transfer proteins (LTPs), which accelerate and modulate the distribution of phospholipids in other organelles. In this regard, LTPs can be established as an essential point within phospholipid circulation, as relevant data show impaired phospholipid transport when LTPs are defected. This review will focus on phospholipid function, metabolism, non-vesicular transport, and associated diseases.https://www.mdpi.com/2227-9059/10/5/1201glycerophospholipidMfn2oxidized phospholipidlipid transport proteinsmembrane contact sites |
| spellingShingle | Raúl Ventura Inma Martínez-Ruiz María Isabel Hernández-Alvarez Phospholipid Membrane Transport and Associated Diseases Biomedicines glycerophospholipid Mfn2 oxidized phospholipid lipid transport proteins membrane contact sites |
| title | Phospholipid Membrane Transport and Associated Diseases |
| title_full | Phospholipid Membrane Transport and Associated Diseases |
| title_fullStr | Phospholipid Membrane Transport and Associated Diseases |
| title_full_unstemmed | Phospholipid Membrane Transport and Associated Diseases |
| title_short | Phospholipid Membrane Transport and Associated Diseases |
| title_sort | phospholipid membrane transport and associated diseases |
| topic | glycerophospholipid Mfn2 oxidized phospholipid lipid transport proteins membrane contact sites |
| url | https://www.mdpi.com/2227-9059/10/5/1201 |
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