BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects
Stress-induced glucocorticoids cause mitochondrial damage in neurons, but they are not cleared by mitophagy. Here, the authors show that glucocorticoids inhibit NIX-dependent basal mitophagy, contributing to neurodegeneration in a mouse model that can be reversed by pretreatment with a NIX enhancer.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-20679-y |
| _version_ | 1818435978585440256 |
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| author | Gee Euhn Choi Hyun Jik Lee Chang Woo Chae Ji Hyeon Cho Young Hyun Jung Jun Sung Kim Seo Yihl Kim Jae Ryong Lim Ho Jae Han |
| author_facet | Gee Euhn Choi Hyun Jik Lee Chang Woo Chae Ji Hyeon Cho Young Hyun Jung Jun Sung Kim Seo Yihl Kim Jae Ryong Lim Ho Jae Han |
| author_sort | Gee Euhn Choi |
| collection | DOAJ |
| description | Stress-induced glucocorticoids cause mitochondrial damage in neurons, but they are not cleared by mitophagy. Here, the authors show that glucocorticoids inhibit NIX-dependent basal mitophagy, contributing to neurodegeneration in a mouse model that can be reversed by pretreatment with a NIX enhancer. |
| first_indexed | 2024-12-14T17:01:28Z |
| format | Article |
| id | doaj.art-2cac894c75774d089073e5f07a58c03c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T17:01:28Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2cac894c75774d089073e5f07a58c03c2022-12-21T22:53:49ZengNature PortfolioNature Communications2041-17232021-01-0112111810.1038/s41467-020-20679-yBNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defectsGee Euhn Choi0Hyun Jik Lee1Chang Woo Chae2Ji Hyeon Cho3Young Hyun Jung4Jun Sung Kim5Seo Yihl Kim6Jae Ryong Lim7Ho Jae Han8Department of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 Four Future Veterinary Medicine Leading Education & Research Center, Seoul National UniversityLaboratory of Veterinary Physiology, College of Veterinary Medicine, Chungbuk National UniversityDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 Four Future Veterinary Medicine Leading Education & Research Center, Seoul National UniversityDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 Four Future Veterinary Medicine Leading Education & Research Center, Seoul National UniversityDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 Four Future Veterinary Medicine Leading Education & Research Center, Seoul National UniversityDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 Four Future Veterinary Medicine Leading Education & Research Center, Seoul National UniversityDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 Four Future Veterinary Medicine Leading Education & Research Center, Seoul National UniversityDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 Four Future Veterinary Medicine Leading Education & Research Center, Seoul National UniversityDepartment of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 Four Future Veterinary Medicine Leading Education & Research Center, Seoul National UniversityStress-induced glucocorticoids cause mitochondrial damage in neurons, but they are not cleared by mitophagy. Here, the authors show that glucocorticoids inhibit NIX-dependent basal mitophagy, contributing to neurodegeneration in a mouse model that can be reversed by pretreatment with a NIX enhancer.https://doi.org/10.1038/s41467-020-20679-y |
| spellingShingle | Gee Euhn Choi Hyun Jik Lee Chang Woo Chae Ji Hyeon Cho Young Hyun Jung Jun Sung Kim Seo Yihl Kim Jae Ryong Lim Ho Jae Han BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects Nature Communications |
| title | BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects |
| title_full | BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects |
| title_fullStr | BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects |
| title_full_unstemmed | BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects |
| title_short | BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects |
| title_sort | bnip3l nix mediated mitophagy protects against glucocorticoid induced synapse defects |
| url | https://doi.org/10.1038/s41467-020-20679-y |
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