Thymoma with an isolated splenic metastasis eight years after extended thymectomy: a case report
Abstract Background Thymomas are typically slow-growing tumors and AB type thymomas are considered no/low risk tumors with a better prognosis. Extra-thoracic metastases are extremely rare. To the best of our knowledge, no patient with an isolated splenic metastasis from a thymoma has been reported....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-12-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-018-5165-0 |
| _version_ | 1818854872861114368 |
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| author | Yuichi Aoki Atsushi Miki Tomoyuki Nakano Hideki Sasanuma Yasunaru Sakuma Hisanaga Horie Yoshinori Hosoya Noriyoshi Fukushima Alan Kawarai Lefor Naohiro Sata |
| author_facet | Yuichi Aoki Atsushi Miki Tomoyuki Nakano Hideki Sasanuma Yasunaru Sakuma Hisanaga Horie Yoshinori Hosoya Noriyoshi Fukushima Alan Kawarai Lefor Naohiro Sata |
| author_sort | Yuichi Aoki |
| collection | DOAJ |
| description | Abstract Background Thymomas are typically slow-growing tumors and AB type thymomas are considered no/low risk tumors with a better prognosis. Extra-thoracic metastases are extremely rare. To the best of our knowledge, no patient with an isolated splenic metastasis from a thymoma has been reported. We report a patient who underwent laparoscopic splenectomy for a slow-growing, isolated splenic metastasis, eight years after thymectomy. Case presentation The patient is a 78-year-old man. Eight years previously, the patient underwent extended thymectomy and postoperative radiation therapy for a thymoma. Five years after thymectomy, a nodule appeared in the spleen, and the lesion enlarged gradually for three years thereafter. The patient was referred for further examination and treatment. Computed tomography scan showed a sharply circumscribed 50 mm tumor slightly hypodense and heterogeneous lesion in the spleen. On T2-weighted images on Magnetic Resonance Imaging, the tumor had high intensity, equivalent to or slightly lower than that on T1-weighted images, and no decrease on diffusion-weighted images. The tumor was multinodular and showed a low-signal spoke-wheel sign in the margin, enhanced gradually in the dynamic study. Positron emission tomography-CT scan, showed relatively low accumulation. Surgical resection was undertaken, and pathological examination showed metastatic thymoma. The patient is without recurrence and has no other symptoms three years after splenectomy. Conclusions This is the first report of an isolated splenic metastasis from a thymoma. Further cases are needed to standardize this surgery for such lesions. |
| first_indexed | 2024-12-19T07:59:37Z |
| format | Article |
| id | doaj.art-2cacb71b3e7941a8be1102acb068a468 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-19T07:59:37Z |
| publishDate | 2018-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-2cacb71b3e7941a8be1102acb068a4682022-12-21T20:29:54ZengBMCBMC Cancer1471-24072018-12-011811610.1186/s12885-018-5165-0Thymoma with an isolated splenic metastasis eight years after extended thymectomy: a case reportYuichi Aoki0Atsushi Miki1Tomoyuki Nakano2Hideki Sasanuma3Yasunaru Sakuma4Hisanaga Horie5Yoshinori Hosoya6Noriyoshi Fukushima7Alan Kawarai Lefor8Naohiro Sata9Department of Surgery, Jichi Medical UniversityDepartment of Surgery, Jichi Medical UniversityDepartment of Surgery, Jichi Medical UniversityDepartment of Surgery, Jichi Medical UniversityDepartment of Surgery, Jichi Medical UniversityDepartment of Surgery, Jichi Medical UniversityDepartment of Surgery, Jichi Medical UniversityDepartment of Diagnostic Pathology, Jichi Medical UniversityDepartment of Surgery, Jichi Medical UniversityDepartment of Surgery, Jichi Medical UniversityAbstract Background Thymomas are typically slow-growing tumors and AB type thymomas are considered no/low risk tumors with a better prognosis. Extra-thoracic metastases are extremely rare. To the best of our knowledge, no patient with an isolated splenic metastasis from a thymoma has been reported. We report a patient who underwent laparoscopic splenectomy for a slow-growing, isolated splenic metastasis, eight years after thymectomy. Case presentation The patient is a 78-year-old man. Eight years previously, the patient underwent extended thymectomy and postoperative radiation therapy for a thymoma. Five years after thymectomy, a nodule appeared in the spleen, and the lesion enlarged gradually for three years thereafter. The patient was referred for further examination and treatment. Computed tomography scan showed a sharply circumscribed 50 mm tumor slightly hypodense and heterogeneous lesion in the spleen. On T2-weighted images on Magnetic Resonance Imaging, the tumor had high intensity, equivalent to or slightly lower than that on T1-weighted images, and no decrease on diffusion-weighted images. The tumor was multinodular and showed a low-signal spoke-wheel sign in the margin, enhanced gradually in the dynamic study. Positron emission tomography-CT scan, showed relatively low accumulation. Surgical resection was undertaken, and pathological examination showed metastatic thymoma. The patient is without recurrence and has no other symptoms three years after splenectomy. Conclusions This is the first report of an isolated splenic metastasis from a thymoma. Further cases are needed to standardize this surgery for such lesions.http://link.springer.com/article/10.1186/s12885-018-5165-0SpleenThymic tumorMetastasisLaparoscopic splenectomy |
| spellingShingle | Yuichi Aoki Atsushi Miki Tomoyuki Nakano Hideki Sasanuma Yasunaru Sakuma Hisanaga Horie Yoshinori Hosoya Noriyoshi Fukushima Alan Kawarai Lefor Naohiro Sata Thymoma with an isolated splenic metastasis eight years after extended thymectomy: a case report BMC Cancer Spleen Thymic tumor Metastasis Laparoscopic splenectomy |
| title | Thymoma with an isolated splenic metastasis eight years after extended thymectomy: a case report |
| title_full | Thymoma with an isolated splenic metastasis eight years after extended thymectomy: a case report |
| title_fullStr | Thymoma with an isolated splenic metastasis eight years after extended thymectomy: a case report |
| title_full_unstemmed | Thymoma with an isolated splenic metastasis eight years after extended thymectomy: a case report |
| title_short | Thymoma with an isolated splenic metastasis eight years after extended thymectomy: a case report |
| title_sort | thymoma with an isolated splenic metastasis eight years after extended thymectomy a case report |
| topic | Spleen Thymic tumor Metastasis Laparoscopic splenectomy |
| url | http://link.springer.com/article/10.1186/s12885-018-5165-0 |
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