A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice

A Pre-Existing Myogenic Temporomandibular Disorder Increases Trigeminal Calcitonin Gene-Related Peptide and Enhances Nitroglycerin-Induced Hypersensitivity in Mice

Migraine is commonly reported among patients with temporomandibular disorders (TMDs), especially myogenic TMD. The pathophysiologic mechanisms related to the comorbidity of the two conditions remain elusive. In the present study, we combined masseter muscle tendon ligation (MMTL)-produced myogenic T...

Full description

Bibliographic Details
Main Authors:	Hui Shu, Sufang Liu, Yuanyuan Tang, Brian L. Schmidt, John C. Dolan, Larry L. Bellinger, Phillip R. Kramer, Steven D. Bender, Feng Tao
Format:	Article
Language:	English
Published:	MDPI AG 2020-06-01
Series:	International Journal of Molecular Sciences
Subjects:	temporomandibular disorder migraine pain comorbidity spinal trigeminal nucleus caudalis calcitonin gene-related peptide
Online Access:	https://www.mdpi.com/1422-0067/21/11/4049

Similar Items

Transcriptomic Analysis of Trigeminal Ganglion and Spinal Trigeminal Nucleus Caudalis in Mice with Inflammatory Temporomandibular Joint Pain
by: Dong T, et al.
Published: (2022-05-01)

The study of the Mongolian traditional medicine Khurtsiin deed-6 analgesic and anti-inflammatory effect by inhibiting glial cell activation in nitroglycerin-induced migraine in rats
by: Jargalsaikhan Gombodorj, et al.
Published: (2023-02-01)

Sex Differences in Estradiol Secretion by Trigeminal Brainstem Neurons
by: David A. Bereiter, et al.
Published: (2019-02-01)

Excitatory Effects of Calcitonin Gene-Related Peptide (CGRP) on Superficial Sp5C Neurons in Mouse Medullary Slices
by: Fang Zheng, et al.
Published: (2021-04-01)

Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation
by: Feng Jing, et al.
Published: (2021-07-01)

A study on the correlation of the asymmetric regulation between the periaqueductal gray and the bilateral trigeminal nucleus caudalis in migraine male rats
by: Zhijian Cao, et al.
Published: (2023-03-01)

Calcitonin gene-related peptide facilitates sensitization of the vestibular nucleus in a rat model of chronic migraine
by: Yun Zhang, et al.
Published: (2020-06-01)

Potential mechanisms for osteopathic manipulative treatment to alleviate migraine-like pain in female rats
by: Katherine Byrd, et al.
Published: (2024-02-01)

AMPK activation attenuates central sensitization in a recurrent nitroglycerin-induced chronic migraine mouse model by promoting microglial M2-type polarization
by: Guangshuang Lu, et al.
Published: (2024-03-01)

The Up-regulation of TNF-α Maintains Trigeminal Neuralgia by Modulating MAPKs Phosphorylation and BKCa Channels in Trigeminal Nucleus Caudalis
by: Zhan-ying Lu, et al.
Published: (2021-11-01)

Calcitonin Gene-Related Peptide-Mediated Trigeminal Ganglionitis: The Biomolecular Link between Temporomandibular Disorders and Chronic Headaches
by: Linda Sangalli, et al.
Published: (2023-07-01)

P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine
by: Feng Jing, et al.
Published: (2019-11-01)

The ditans, a new class for acute migraine: Minireview
by: Jamir Pitton Rissardo, et al.
Published: (2020-01-01)

Differences in Neuropathology between Nitroglycerin-Induced Mouse Models of Episodic and Chronic Migraine
by: Songyi Park, et al.
Published: (2024-03-01)

Pathological Mechanisms and Therapeutic Targets for Trigeminal Neuropathic Pain
by: Pawan Bista, et al.
Published: (2019-08-01)

CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons
by: Tayla A. Rees, et al.
Published: (2022-05-01)

Calcitonin Gene-Related Peptide mRNA Synthesis in Trigeminal Ganglion Neurons after Cortical Spreading Depolarization
by: Mamoru Shibata, et al.
Published: (2023-07-01)

The effect of capsaicin on expression patterns of CGRP in trigeminal ganglion and trigeminal nucleus caudalis following experimental tooth movement in rats
by: Yang ZHOU, et al.

Commentary: The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat
by: Marcelo Moraes Valença
Published: (2017-09-01)

Botulinum Neurotoxin Chimeras Suppress Stimulation by Capsaicin of Rat Trigeminal Sensory Neurons In Vivo and In Vitro
by: Caren Antoniazzi, et al.
Published: (2022-02-01)

Hydrogen Sulfide Mediating both Excitatory and Inhibitory Effects in a Rat Model of Meningeal Nociception and Headache Generation
by: Christiane Teicher, et al.
Published: (2017-07-01)

Mode and site of action of therapies targeting CGRP signaling
by: Alejandro Labastida-Ramírez, et al.
Published: (2023-09-01)

Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective
by: Xiaoping Hong, et al.
Published: (2023-12-01)

The Anti-Calcitonin Gene-Related Peptide (Anti-CGRP) Antibody Fremanezumab Reduces Trigeminal Neurons Immunoreactive to CGRP and CGRP Receptor Components in Rats
by: Birgit Vogler, et al.
Published: (2023-08-01)

NMDAR and JNK Activation in the Spinal Trigeminal Nucleus Caudalis Contributes to Masseter Hyperalgesia Induced by Stress
by: Wenqing Lin, et al.
Published: (2019-11-01)

Orofacial Neuropathic Pain-Basic Research and Their Clinical Relevancies
by: Masamichi Shinoda, et al.
Published: (2021-07-01)

Gray zones in the trigeminal autonomic cephalalgias
by: Nevra Oksuz, et al.
Published: (2023-01-01)

CGRP and Migraine: What Have We Learned From Measuring CGRP in Migraine Patients So Far?
by: Katharina Kamm
Published: (2022-07-01)

SOMATOTOPY OF THE TRIGEMINAL COMPLEX: NERVE, GANGLION, NUCLEUS.
by: Alessio Lipari
Published: (2017-12-01)

Grape seed extract suppresses calcitonin gene-related peptide secretion and upregulates expression of GAD 65/67 and GABAB receptor in primary trigeminal ganglion cultures
by: Sophia R. Antonopoulos, et al.
Published: (2022-12-01)

Commentary: Constipation caused by anti-calcitonin gene-related peptide migraine therapeutics explained by antagonism of calcitonin gene-related peptide’s motor-stimulating and prosecretory function in the intestine
by: Kimberly D. Mackenzie, et al.
Published: (2022-11-01)

Testing the Role of Glutamate NMDA Receptors in Peripheral Trigeminal Nociception Implicated in Migraine Pain
by: Cindy Guerrero-Toro, et al.
Published: (2022-01-01)

Phenotypic alterations of neuropeptide Y and calcitonin gene-related peptide-containing neurons innervating the rat temporomandibular joint during carrageenan-induced arthritis
by: J.P. Damico, et al.
Published: (2012-10-01)

Involvement of peripheral ionotropic glutamate receptors in orofacial thermal hyperalgesia in rats
by: Katagiri Ayano, et al.
Published: (2011-09-01)

Calcitonin Gene-Related Peptide Systemic Effects: Embracing the Complexity of Its Biological Roles—A Narrative Review
by: Adriano Bonura, et al.
Published: (2023-09-01)

Dopaminergic Modulation of Orofacial Mechanical Hypersensitivity Induced by Infraorbital Nerve Injury
by: Hiroharu Maegawa, et al.
Published: (2020-03-01)

Temporomandibular disorder in chronic migraine
by: N. V. Latysheva, et al.
Published: (2017-12-01)

An experimental research on the expression of c-Fos protein in trigeminal nucleus caudalis of migraine rat model induced by nitroglycerin after the intervention of Yangxueqingnao granules
by: Xiao-feng LEI, et al.
Published: (2014-08-01)

Electroacupuncture at Fengchi (GB20) inhibits calcitonin gene-related peptide expression in the trigeminovascular system of a rat model of migraine
by: Luo-peng Zhao, et al.
Published: (2017-01-01)

Association of serum levels of calcitonin gene-related peptide and cytokines during migraine attacks
by: Dawei Han
Published: (2019-01-01)