The roles of vitamin D and dietary calcium in nutritional rickets
The etiology and pathogenesis of nutritional rickets are becoming progressively clearer. Vitamin D deficiency has generally been considered the major or only player in the pathogenesis of nutritional rickets. However, recent research into calcium deficiency has now provided clinicians with reasons t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-06-01
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| Series: | Bone Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352187218300056 |
| _version_ | 1819112786177818624 |
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| author | Kebashni Thandrayen John M. Pettifor |
| author_facet | Kebashni Thandrayen John M. Pettifor |
| author_sort | Kebashni Thandrayen |
| collection | DOAJ |
| description | The etiology and pathogenesis of nutritional rickets are becoming progressively clearer. Vitamin D deficiency has generally been considered the major or only player in the pathogenesis of nutritional rickets. However, recent research into calcium deficiency has now provided clinicians with reasons to investigate and manage patients with nutritional rickets more appropriately.The important question when assessing cases of nutritional rickets is: “Is it calcium or vitamin D deficiency or both that play a major role in the pathogenesis of the disease?”The case presentation in this review highlights the risk factors, clinical presentation and pathophysiology of nutritional rickets in a young South African black child from a semi-urban area in Johannesburg, a city with abundant sunshine throughout the year. Keywords: Nutritional rickets, Vitamin D, Dietary calcium, 1,25 dihydroxyvitamin D |
| first_indexed | 2024-12-22T04:19:02Z |
| format | Article |
| id | doaj.art-2cb364b77e19406180199e5ebe16a751 |
| institution | Directory Open Access Journal |
| issn | 2352-1872 |
| language | English |
| last_indexed | 2024-12-22T04:19:02Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Bone Reports |
| spelling | doaj.art-2cb364b77e19406180199e5ebe16a7512022-12-21T18:39:20ZengElsevierBone Reports2352-18722018-06-0188189The roles of vitamin D and dietary calcium in nutritional ricketsKebashni Thandrayen0John M. Pettifor1Department of Paediatrics, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Corresponding author.Department of Paediatrics, MRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaThe etiology and pathogenesis of nutritional rickets are becoming progressively clearer. Vitamin D deficiency has generally been considered the major or only player in the pathogenesis of nutritional rickets. However, recent research into calcium deficiency has now provided clinicians with reasons to investigate and manage patients with nutritional rickets more appropriately.The important question when assessing cases of nutritional rickets is: “Is it calcium or vitamin D deficiency or both that play a major role in the pathogenesis of the disease?”The case presentation in this review highlights the risk factors, clinical presentation and pathophysiology of nutritional rickets in a young South African black child from a semi-urban area in Johannesburg, a city with abundant sunshine throughout the year. Keywords: Nutritional rickets, Vitamin D, Dietary calcium, 1,25 dihydroxyvitamin Dhttp://www.sciencedirect.com/science/article/pii/S2352187218300056 |
| spellingShingle | Kebashni Thandrayen John M. Pettifor The roles of vitamin D and dietary calcium in nutritional rickets Bone Reports |
| title | The roles of vitamin D and dietary calcium in nutritional rickets |
| title_full | The roles of vitamin D and dietary calcium in nutritional rickets |
| title_fullStr | The roles of vitamin D and dietary calcium in nutritional rickets |
| title_full_unstemmed | The roles of vitamin D and dietary calcium in nutritional rickets |
| title_short | The roles of vitamin D and dietary calcium in nutritional rickets |
| title_sort | roles of vitamin d and dietary calcium in nutritional rickets |
| url | http://www.sciencedirect.com/science/article/pii/S2352187218300056 |
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