Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk
Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint disease that is recognized as the most common type of arthritis. During the last decade, it shows an incremental global rise in prevalence and incidence. The interaction between etiologic factors that medi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/4120 |
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| author | Sofija Semenistaja Sandra Skuja Anda Kadisa Valerija Groma |
| author_facet | Sofija Semenistaja Sandra Skuja Anda Kadisa Valerija Groma |
| author_sort | Sofija Semenistaja |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint disease that is recognized as the most common type of arthritis. During the last decade, it shows an incremental global rise in prevalence and incidence. The interaction between etiologic factors that mediate joint degradation has been explored in numerous studies. However, the underlying processes that induce OA remain obscure, largely due to the variety and complexity of these mechanisms. During synovial joint dysfunction, the osteochondral unit undergoes cellular phenotypic and functional alterations. At the cellular level, the synovial membrane is influenced by cartilage and subchondral bone cleavage fragments and extracellular matrix (ECM) degradation products from apoptotic and necrotic cells. These “foreign bodies” serve as danger-associated molecular patterns (DAMPs) that trigger innate immunity, eliciting and sustaining low-grade inflammation in the synovium. In this review, we explore the cellular and molecular communication networks established between the major joint compartments—the synovial membrane, cartilage, and subchondral bone of normal and OA-affected joints. |
| first_indexed | 2024-03-11T08:40:32Z |
| format | Article |
| id | doaj.art-2cb3a303e19c492999870b83a4e09f30 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:40:32Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2cb3a303e19c492999870b83a4e09f302023-11-16T21:09:47ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244412010.3390/ijms24044120Healthy and Osteoarthritis-Affected Joints Facing the Cellular CrosstalkSofija Semenistaja0Sandra Skuja1Anda Kadisa2Valerija Groma3Department of Doctoral Studies, Rīga Stradiņš University, LV-1007 Riga, LatviaJoint Laboratory of Electron Microscopy, Institute of Anatomy and Anthropology, Rīga Stradiņš University, LV-1007 Riga, LatviaDepartment of Internal Diseases, Rīga Stradiņš University, LV-1007 Riga, LatviaJoint Laboratory of Electron Microscopy, Institute of Anatomy and Anthropology, Rīga Stradiņš University, LV-1007 Riga, LatviaOsteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint disease that is recognized as the most common type of arthritis. During the last decade, it shows an incremental global rise in prevalence and incidence. The interaction between etiologic factors that mediate joint degradation has been explored in numerous studies. However, the underlying processes that induce OA remain obscure, largely due to the variety and complexity of these mechanisms. During synovial joint dysfunction, the osteochondral unit undergoes cellular phenotypic and functional alterations. At the cellular level, the synovial membrane is influenced by cartilage and subchondral bone cleavage fragments and extracellular matrix (ECM) degradation products from apoptotic and necrotic cells. These “foreign bodies” serve as danger-associated molecular patterns (DAMPs) that trigger innate immunity, eliciting and sustaining low-grade inflammation in the synovium. In this review, we explore the cellular and molecular communication networks established between the major joint compartments—the synovial membrane, cartilage, and subchondral bone of normal and OA-affected joints.https://www.mdpi.com/1422-0067/24/4/4120osteoarthritissynovial membranearticular cartilagesubchondral bonesynoviocyteschondrocytes |
| spellingShingle | Sofija Semenistaja Sandra Skuja Anda Kadisa Valerija Groma Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk International Journal of Molecular Sciences osteoarthritis synovial membrane articular cartilage subchondral bone synoviocytes chondrocytes |
| title | Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk |
| title_full | Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk |
| title_fullStr | Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk |
| title_full_unstemmed | Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk |
| title_short | Healthy and Osteoarthritis-Affected Joints Facing the Cellular Crosstalk |
| title_sort | healthy and osteoarthritis affected joints facing the cellular crosstalk |
| topic | osteoarthritis synovial membrane articular cartilage subchondral bone synoviocytes chondrocytes |
| url | https://www.mdpi.com/1422-0067/24/4/4120 |
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