Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
Summary: While the pivotal role of linker histone H1 in shaping nucleosome organization is well established, its functional interplays with chromatin factors along the epigenome are just starting to emerge. Here we show that, in Arabidopsis, as in mammals, H1 occupies Polycomb Repressive Complex 2 (...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723009051 |
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| author | Gianluca Teano Lorenzo Concia Léa Wolff Léopold Carron Ivona Biocanin Kateřina Adamusová Miloslava Fojtová Michael Bourge Amira Kramdi Vincent Colot Ueli Grossniklaus Chris Bowler Célia Baroux Alessandra Carbone Aline V. Probst Petra Procházková Schrumpfová Jiří Fajkus Simon Amiard Stefan Grob Clara Bourbousse Fredy Barneche |
| author_facet | Gianluca Teano Lorenzo Concia Léa Wolff Léopold Carron Ivona Biocanin Kateřina Adamusová Miloslava Fojtová Michael Bourge Amira Kramdi Vincent Colot Ueli Grossniklaus Chris Bowler Célia Baroux Alessandra Carbone Aline V. Probst Petra Procházková Schrumpfová Jiří Fajkus Simon Amiard Stefan Grob Clara Bourbousse Fredy Barneche |
| author_sort | Gianluca Teano |
| collection | DOAJ |
| description | Summary: While the pivotal role of linker histone H1 in shaping nucleosome organization is well established, its functional interplays with chromatin factors along the epigenome are just starting to emerge. Here we show that, in Arabidopsis, as in mammals, H1 occupies Polycomb Repressive Complex 2 (PRC2) target genes where it favors chromatin condensation and H3K27me3 deposition. We further show that, contrasting with its conserved function in PRC2 activation at genes, H1 selectively prevents H3K27me3 accumulation at telomeres and large pericentromeric interstitial telomeric repeat (ITR) domains by restricting DNA accessibility to Telomere Repeat Binding (TRB) proteins, a group of H1-related Myb factors mediating PRC2 cis recruitment. This study provides a mechanistic framework by which H1 avoids the formation of gigantic H3K27me3-rich domains at telomeric sequences and contributes to safeguard nucleus architecture. |
| first_indexed | 2024-03-12T11:53:15Z |
| format | Article |
| id | doaj.art-2cb515424a7d44d5acaf6a6fd6ff42c4 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-12T11:53:15Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-2cb515424a7d44d5acaf6a6fd6ff42c42023-08-31T05:02:05ZengElsevierCell Reports2211-12472023-08-01428112894Histone H1 protects telomeric repeats from H3K27me3 invasion in ArabidopsisGianluca Teano0Lorenzo Concia1Léa Wolff2Léopold Carron3Ivona Biocanin4Kateřina Adamusová5Miloslava Fojtová6Michael Bourge7Amira Kramdi8Vincent Colot9Ueli Grossniklaus10Chris Bowler11Célia Baroux12Alessandra Carbone13Aline V. Probst14Petra Procházková Schrumpfová15Jiří Fajkus16Simon Amiard17Stefan Grob18Clara Bourbousse19Fredy Barneche20Institut de biologie de l’École normale supérieure (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, Paris, France; Université Paris-Saclay, 91190 Orsay, FranceInstitut de biologie de l’École normale supérieure (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, Paris, FranceInstitut de biologie de l’École normale supérieure (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, Paris, FranceSorbonne Université, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, FranceInstitut de biologie de l’École normale supérieure (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, Paris, France; Université Paris-Saclay, 91190 Orsay, FranceMendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Laboratory of Functional Genomics and Proteomics, NCBR, Faculty of Science, Masaryk University, Brno, Czech RepublicMendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Laboratory of Functional Genomics and Proteomics, NCBR, Faculty of Science, Masaryk University, Brno, Czech RepublicCytometry Facility, Imagerie-Gif, Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, FranceInstitut de biologie de l’École normale supérieure (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, Paris, FranceInstitut de biologie de l’École normale supérieure (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, Paris, FranceDepartment of Plant and Microbial Biology & Zurich-Basel Plant Science Center, University of Zurich, Zurich, SwitzerlandInstitut de biologie de l’École normale supérieure (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, Paris, FranceDepartment of Plant and Microbial Biology & Zurich-Basel Plant Science Center, University of Zurich, Zurich, SwitzerlandSorbonne Université, CNRS, IBPS, UMR 7238, Laboratoire de Biologie Computationnelle et Quantitative (LCQB), 75005 Paris, FranceCNRS UMR6293, Université Clermont Auvergne, INSERM U1103, GReD, CRBC, Clermont-Ferrand, FranceMendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Laboratory of Functional Genomics and Proteomics, NCBR, Faculty of Science, Masaryk University, Brno, Czech RepublicMendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Laboratory of Functional Genomics and Proteomics, NCBR, Faculty of Science, Masaryk University, Brno, Czech RepublicCNRS UMR6293, Université Clermont Auvergne, INSERM U1103, GReD, CRBC, Clermont-Ferrand, FranceDepartment of Plant and Microbial Biology & Zurich-Basel Plant Science Center, University of Zurich, Zurich, SwitzerlandInstitut de biologie de l’École normale supérieure (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, Paris, FranceInstitut de biologie de l’École normale supérieure (IBENS), École normale supérieure, CNRS, INSERM, Université PSL, Paris, France; Corresponding authorSummary: While the pivotal role of linker histone H1 in shaping nucleosome organization is well established, its functional interplays with chromatin factors along the epigenome are just starting to emerge. Here we show that, in Arabidopsis, as in mammals, H1 occupies Polycomb Repressive Complex 2 (PRC2) target genes where it favors chromatin condensation and H3K27me3 deposition. We further show that, contrasting with its conserved function in PRC2 activation at genes, H1 selectively prevents H3K27me3 accumulation at telomeres and large pericentromeric interstitial telomeric repeat (ITR) domains by restricting DNA accessibility to Telomere Repeat Binding (TRB) proteins, a group of H1-related Myb factors mediating PRC2 cis recruitment. This study provides a mechanistic framework by which H1 avoids the formation of gigantic H3K27me3-rich domains at telomeric sequences and contributes to safeguard nucleus architecture.http://www.sciencedirect.com/science/article/pii/S2211124723009051CP: Molecular biologyCP: Plants |
| spellingShingle | Gianluca Teano Lorenzo Concia Léa Wolff Léopold Carron Ivona Biocanin Kateřina Adamusová Miloslava Fojtová Michael Bourge Amira Kramdi Vincent Colot Ueli Grossniklaus Chris Bowler Célia Baroux Alessandra Carbone Aline V. Probst Petra Procházková Schrumpfová Jiří Fajkus Simon Amiard Stefan Grob Clara Bourbousse Fredy Barneche Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis Cell Reports CP: Molecular biology CP: Plants |
| title | Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis |
| title_full | Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis |
| title_fullStr | Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis |
| title_full_unstemmed | Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis |
| title_short | Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis |
| title_sort | histone h1 protects telomeric repeats from h3k27me3 invasion in arabidopsis |
| topic | CP: Molecular biology CP: Plants |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723009051 |
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