Investigating local and systemic intestinal signalling in health and disease with Drosophila
Whole-body health relies on complex inter-organ signalling networks that enable organisms to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine plays a major role as a signalling centre by producing local and systemic signals that are relayed to the body and tha...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Company of Biologists
2022-03-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/15/3/dmm049332 |
| _version_ | 1818201919767707648 |
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| author | Andre Medina Karen Bellec Sofia Polcowñuk Julia B. Cordero |
| author_facet | Andre Medina Karen Bellec Sofia Polcowñuk Julia B. Cordero |
| author_sort | Andre Medina |
| collection | DOAJ |
| description | Whole-body health relies on complex inter-organ signalling networks that enable organisms to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine plays a major role as a signalling centre by producing local and systemic signals that are relayed to the body and that maintain intestinal and organismal homeostasis. Consequently, disruption of intestinal homeostasis and signalling are associated with systemic diseases and multi-organ dysfunction. In recent years, the fruit fly Drosophila melanogaster has emerged as a prime model organism to study tissue-intrinsic and systemic signalling networks of the adult intestine due to its genetic tractability and functional conservation with mammals. In this Review, we highlight Drosophila research that has contributed to our understanding of how the adult intestine interacts with its microenvironment and with distant organs. We discuss the implications of these findings for understanding intestinal and whole-body pathophysiology, and how future Drosophila studies might advance our knowledge of the complex interplay between the intestine and the rest of the body in health and disease. |
| first_indexed | 2024-12-12T03:01:12Z |
| format | Article |
| id | doaj.art-2cb6af41db104faa944da3221d92e463 |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-12-12T03:01:12Z |
| publishDate | 2022-03-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-2cb6af41db104faa944da3221d92e4632022-12-22T00:40:37ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112022-03-0115310.1242/dmm.049332049332Investigating local and systemic intestinal signalling in health and disease with DrosophilaAndre Medina0Karen Bellec1Sofia Polcowñuk2Julia B. Cordero3 Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Glasgow G61 1QH, UK Whole-body health relies on complex inter-organ signalling networks that enable organisms to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine plays a major role as a signalling centre by producing local and systemic signals that are relayed to the body and that maintain intestinal and organismal homeostasis. Consequently, disruption of intestinal homeostasis and signalling are associated with systemic diseases and multi-organ dysfunction. In recent years, the fruit fly Drosophila melanogaster has emerged as a prime model organism to study tissue-intrinsic and systemic signalling networks of the adult intestine due to its genetic tractability and functional conservation with mammals. In this Review, we highlight Drosophila research that has contributed to our understanding of how the adult intestine interacts with its microenvironment and with distant organs. We discuss the implications of these findings for understanding intestinal and whole-body pathophysiology, and how future Drosophila studies might advance our knowledge of the complex interplay between the intestine and the rest of the body in health and disease.http://dmm.biologists.org/content/15/3/dmm049332drosophilaintestinediseasehealthinter-organ communication |
| spellingShingle | Andre Medina Karen Bellec Sofia Polcowñuk Julia B. Cordero Investigating local and systemic intestinal signalling in health and disease with Drosophila Disease Models & Mechanisms drosophila intestine disease health inter-organ communication |
| title | Investigating local and systemic intestinal signalling in health and disease with Drosophila |
| title_full | Investigating local and systemic intestinal signalling in health and disease with Drosophila |
| title_fullStr | Investigating local and systemic intestinal signalling in health and disease with Drosophila |
| title_full_unstemmed | Investigating local and systemic intestinal signalling in health and disease with Drosophila |
| title_short | Investigating local and systemic intestinal signalling in health and disease with Drosophila |
| title_sort | investigating local and systemic intestinal signalling in health and disease with drosophila |
| topic | drosophila intestine disease health inter-organ communication |
| url | http://dmm.biologists.org/content/15/3/dmm049332 |
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