Air pollution nanoparticle and alpha-synuclein fibrils synergistically decrease glutamate receptor A1, depending upon nPM batch activity

Air pollution nanoparticle and alpha-synuclein fibrils synergistically decrease glutamate receptor A1, depending upon nPM batch activity

Background: Epidemiological studies have variably linked air pollution to increased risk of Parkinson’s disease (PD). However, there is little experimental evidence for this association. Alpha-synuclein (α-syn) propagation plays central roles in PD and glutamate receptor A1 (GluA1) is involved in me...

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Bibliographic Details
Main Authors: Hongqiao Zhang, Carla D'Agostino, Christopher Tulisiak, Max A. Thorwald, Liza Bergkvist, Allison Lindquist, Lindsay Meyerdirk, Emily Schulz, Katelyn Becker, Jennifer A. Steiner, Mafalda Cacciottolo, Mohit Kwatra, Nolwen L. Rey, Martha L. Escobar Galvis, Jiyan Ma, Constantinos Sioutas, Todd E. Morgan, Caleb E. Finch, Patrik Brundin
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Heliyon
Subjects:
Parkinson’s disease
α-synuclein
Air pollution
Nanoparticles
Iba1
Glutamate receptor A1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023028293

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023028293

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