Thioredoxins: Emerging Players in the Regulation of Protein S-Nitrosation in Plants
S-nitrosation has been recognized as an important mechanism of ubiquitous posttranslational modification of proteins on the basis of the attachment of the nitroso group to cysteine thiols. Reversible S-nitrosation, similarly to other redox-based modifications of protein thiols, has a profound effect...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-10-01
|
| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/9/11/1426 |
| _version_ | 1827703612339388416 |
|---|---|
| author | Tereza Jedelská Lenka Luhová Marek Petřivalský |
| author_facet | Tereza Jedelská Lenka Luhová Marek Petřivalský |
| author_sort | Tereza Jedelská |
| collection | DOAJ |
| description | S-nitrosation has been recognized as an important mechanism of ubiquitous posttranslational modification of proteins on the basis of the attachment of the nitroso group to cysteine thiols. Reversible S-nitrosation, similarly to other redox-based modifications of protein thiols, has a profound effect on protein structure and activity and is considered as a convergence of signaling pathways of reactive nitrogen and oxygen species. This review summarizes the current knowledge on the emerging role of the thioredoxin-thioredoxin reductase (TRXR-TRX) system in protein denitrosation. Important advances have been recently achieved on plant thioredoxins (TRXs) and their properties, regulation, and functions in the control of protein S-nitrosation in plant root development, translation of photosynthetic light harvesting proteins, and immune responses. Future studies of plants with down- and upregulated TRXs together with the application of genomics and proteomics approaches will contribute to obtain new insights into plant S-nitrosothiol metabolism and its regulation. |
| first_indexed | 2024-03-10T15:22:27Z |
| format | Article |
| id | doaj.art-2cb8277b596446258bcc0a0d9199e576 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T15:22:27Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-2cb8277b596446258bcc0a0d9199e5762023-11-20T18:22:28ZengMDPI AGPlants2223-77472020-10-01911142610.3390/plants9111426Thioredoxins: Emerging Players in the Regulation of Protein S-Nitrosation in PlantsTereza Jedelská0Lenka Luhová1Marek Petřivalský2Department of Biochemistry, Faculty of Science, Palacký University, Šlechtitelů 27, 78371 Olomouc, Czech RepublicDepartment of Biochemistry, Faculty of Science, Palacký University, Šlechtitelů 27, 78371 Olomouc, Czech RepublicDepartment of Biochemistry, Faculty of Science, Palacký University, Šlechtitelů 27, 78371 Olomouc, Czech RepublicS-nitrosation has been recognized as an important mechanism of ubiquitous posttranslational modification of proteins on the basis of the attachment of the nitroso group to cysteine thiols. Reversible S-nitrosation, similarly to other redox-based modifications of protein thiols, has a profound effect on protein structure and activity and is considered as a convergence of signaling pathways of reactive nitrogen and oxygen species. This review summarizes the current knowledge on the emerging role of the thioredoxin-thioredoxin reductase (TRXR-TRX) system in protein denitrosation. Important advances have been recently achieved on plant thioredoxins (TRXs) and their properties, regulation, and functions in the control of protein S-nitrosation in plant root development, translation of photosynthetic light harvesting proteins, and immune responses. Future studies of plants with down- and upregulated TRXs together with the application of genomics and proteomics approaches will contribute to obtain new insights into plant S-nitrosothiol metabolism and its regulation.https://www.mdpi.com/2223-7747/9/11/1426denitrosationnitric oxideS-nitrosationplant redox signalingreactive nitrogen speciesthioredoxin |
| spellingShingle | Tereza Jedelská Lenka Luhová Marek Petřivalský Thioredoxins: Emerging Players in the Regulation of Protein S-Nitrosation in Plants Plants denitrosation nitric oxide S-nitrosation plant redox signaling reactive nitrogen species thioredoxin |
| title | Thioredoxins: Emerging Players in the Regulation of Protein S-Nitrosation in Plants |
| title_full | Thioredoxins: Emerging Players in the Regulation of Protein S-Nitrosation in Plants |
| title_fullStr | Thioredoxins: Emerging Players in the Regulation of Protein S-Nitrosation in Plants |
| title_full_unstemmed | Thioredoxins: Emerging Players in the Regulation of Protein S-Nitrosation in Plants |
| title_short | Thioredoxins: Emerging Players in the Regulation of Protein S-Nitrosation in Plants |
| title_sort | thioredoxins emerging players in the regulation of protein s nitrosation in plants |
| topic | denitrosation nitric oxide S-nitrosation plant redox signaling reactive nitrogen species thioredoxin |
| url | https://www.mdpi.com/2223-7747/9/11/1426 |
| work_keys_str_mv | AT terezajedelska thioredoxinsemergingplayersintheregulationofproteinsnitrosationinplants AT lenkaluhova thioredoxinsemergingplayersintheregulationofproteinsnitrosationinplants AT marekpetrivalsky thioredoxinsemergingplayersintheregulationofproteinsnitrosationinplants |