Noninvasive Assessment of Interstitial Fibrosis and Tubular Atrophy in Renal Transplant by Combining Point-Shear Wave Elastography and Estimated Glomerular Filtration Rate
The purpose of this study was to evaluate the feasibility of the combination of point-shear wave elastography (p-SWE) and estimated glomerular filtration rate (eGFR) for assessing different stages of interstitial fibrosis and tubular atrophy (IF/TA) in patients with chronic renal allograft dysfuncti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/1/18 |
| _version_ | 1797494777155944448 |
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| author | Chi Qin Hailong Jin Haixiang Zhang Yun Zhang Zhaojie Guan Yongyan Gao |
| author_facet | Chi Qin Hailong Jin Haixiang Zhang Yun Zhang Zhaojie Guan Yongyan Gao |
| author_sort | Chi Qin |
| collection | DOAJ |
| description | The purpose of this study was to evaluate the feasibility of the combination of point-shear wave elastography (p-SWE) and estimated glomerular filtration rate (eGFR) for assessing different stages of interstitial fibrosis and tubular atrophy (IF/TA) in patients with chronic renal allograft dysfunction (CAD). From September 2020 to August 2021, 47 patients who underwent renal biopsy and p-SWE examinations were consecutively enrolled in this study. The areas under the receiver operating characteristic curves (AUCs) were calculated to evaluate overall accuracy and to identify the optimal cutoff values for different IF/TA stages. A total of 43 patients were enrolled in this study. The renal cortical stiffness and eGFR showed a significant difference between IF/TA Grade 0–1 and Grade 2–3 (<i>p</i> < 0.001). Additionally, renal stiffness and eGFR were independent predictors for moderate-to-severe IF/TA (Grade ≥ 2) according to multiple logistic regression analysis. The combination of p-SWE and eGFR, with an optimal cutoff value of −1.63, was superior to eGFR alone in assessing moderate-to-severe interstitial fibrosis (AUC, 0.86 vs. 0.72, <i>p</i> = 0.02) or tubular atrophy (AUC, 0.88 vs. 0.74, <i>p</i> = 0.02). There was no difference between p-SWE and eGFR in assessing moderate-to-severe IF/TA (AUC, 0.85 vs. 0.79, <i>p</i> = 0.61). Therefore, combining p-SWE and eGFR is worthy of clinical popularization and application. |
| first_indexed | 2024-03-10T01:39:10Z |
| format | Article |
| id | doaj.art-2cbacef82cb846e0b386441a151e210f |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T01:39:10Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2cbacef82cb846e0b386441a151e210f2023-11-23T13:26:51ZengMDPI AGDiagnostics2075-44182021-12-011211810.3390/diagnostics12010018Noninvasive Assessment of Interstitial Fibrosis and Tubular Atrophy in Renal Transplant by Combining Point-Shear Wave Elastography and Estimated Glomerular Filtration RateChi Qin0Hailong Jin1Haixiang Zhang2Yun Zhang3Zhaojie Guan4Yongyan Gao5The Training Site for Postgraduate of Jinzhou Medical University, Department of Ultrasound, The Third Medical Center of Chinese PLA General Hospital, 69 Yongding Road, Hai Dian, Beijing 100039, ChinaDepartment of Organ Transplantation, The Third Medical Center of Chinese PLA General Hospital, 69 Yongding Road, Hai Dian, Beijing 100039, ChinaDepartment of Ultrasound, The Third Medical Center of Chinese PLA General Hospital, 69 Yongding Road, Hai Dian, Beijing 100039, ChinaDepartment of Ultrasound, The Third Medical Center of Chinese PLA General Hospital, 69 Yongding Road, Hai Dian, Beijing 100039, ChinaDepartment of Organ Transplantation, The Third Medical Center of Chinese PLA General Hospital, 69 Yongding Road, Hai Dian, Beijing 100039, ChinaDepartment of Ultrasound, The Third Medical Center of Chinese PLA General Hospital, 69 Yongding Road, Hai Dian, Beijing 100039, ChinaThe purpose of this study was to evaluate the feasibility of the combination of point-shear wave elastography (p-SWE) and estimated glomerular filtration rate (eGFR) for assessing different stages of interstitial fibrosis and tubular atrophy (IF/TA) in patients with chronic renal allograft dysfunction (CAD). From September 2020 to August 2021, 47 patients who underwent renal biopsy and p-SWE examinations were consecutively enrolled in this study. The areas under the receiver operating characteristic curves (AUCs) were calculated to evaluate overall accuracy and to identify the optimal cutoff values for different IF/TA stages. A total of 43 patients were enrolled in this study. The renal cortical stiffness and eGFR showed a significant difference between IF/TA Grade 0–1 and Grade 2–3 (<i>p</i> < 0.001). Additionally, renal stiffness and eGFR were independent predictors for moderate-to-severe IF/TA (Grade ≥ 2) according to multiple logistic regression analysis. The combination of p-SWE and eGFR, with an optimal cutoff value of −1.63, was superior to eGFR alone in assessing moderate-to-severe interstitial fibrosis (AUC, 0.86 vs. 0.72, <i>p</i> = 0.02) or tubular atrophy (AUC, 0.88 vs. 0.74, <i>p</i> = 0.02). There was no difference between p-SWE and eGFR in assessing moderate-to-severe IF/TA (AUC, 0.85 vs. 0.79, <i>p</i> = 0.61). Therefore, combining p-SWE and eGFR is worthy of clinical popularization and application.https://www.mdpi.com/2075-4418/12/1/18point-shear wave elastographyinterstitial fibrosis and tubular atrophyestimated glomerular filtrationrenal transplantation |
| spellingShingle | Chi Qin Hailong Jin Haixiang Zhang Yun Zhang Zhaojie Guan Yongyan Gao Noninvasive Assessment of Interstitial Fibrosis and Tubular Atrophy in Renal Transplant by Combining Point-Shear Wave Elastography and Estimated Glomerular Filtration Rate Diagnostics point-shear wave elastography interstitial fibrosis and tubular atrophy estimated glomerular filtration renal transplantation |
| title | Noninvasive Assessment of Interstitial Fibrosis and Tubular Atrophy in Renal Transplant by Combining Point-Shear Wave Elastography and Estimated Glomerular Filtration Rate |
| title_full | Noninvasive Assessment of Interstitial Fibrosis and Tubular Atrophy in Renal Transplant by Combining Point-Shear Wave Elastography and Estimated Glomerular Filtration Rate |
| title_fullStr | Noninvasive Assessment of Interstitial Fibrosis and Tubular Atrophy in Renal Transplant by Combining Point-Shear Wave Elastography and Estimated Glomerular Filtration Rate |
| title_full_unstemmed | Noninvasive Assessment of Interstitial Fibrosis and Tubular Atrophy in Renal Transplant by Combining Point-Shear Wave Elastography and Estimated Glomerular Filtration Rate |
| title_short | Noninvasive Assessment of Interstitial Fibrosis and Tubular Atrophy in Renal Transplant by Combining Point-Shear Wave Elastography and Estimated Glomerular Filtration Rate |
| title_sort | noninvasive assessment of interstitial fibrosis and tubular atrophy in renal transplant by combining point shear wave elastography and estimated glomerular filtration rate |
| topic | point-shear wave elastography interstitial fibrosis and tubular atrophy estimated glomerular filtration renal transplantation |
| url | https://www.mdpi.com/2075-4418/12/1/18 |
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