The CMV-Specific CD8<sup>+</sup> T Cell Response Is Dominated by Supra-Public Clonotypes with High Generation Probabilities

The CMV-Specific CD8<sup>+</sup> T Cell Response Is Dominated by Supra-Public Clonotypes with High Generation Probabilities

Evolutionary processes govern the selection of T cell clonotypes that are optimally suited to mediate efficient antigen-specific immune responses against pathogens and tumors. While the theoretical diversity of T cell receptor (TCR) sequences is vast, the antigen-specific TCR repertoire is restricte...

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Bibliographic Details
Main Authors: Kilian Schober, Pim Fuchs, Jonas Mir, Monika Hammel, Lorenzo Fanchi, Michael Flossdorf, Dirk H. Busch
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pathogens
Subjects:
memory inflation
public clonotypes
generation probability
T cell response
TCR
convergent recombination
Online Access:https://www.mdpi.com/2076-0817/9/8/650

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