Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection
Abstract Background The objective of this study was to compare the analgesic potency of oxycodone versus morphine after laparoscopic deep infiltrating endometriosis resection. Methods Fifty patients undergoing laparoscopic deep infiltrating endometriosis resection were randomized to receive oxycodon...
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-021-01417-3 |
| _version_ | 1818573576123449344 |
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| author | Lijun Niu Lihong Chen Yanhua Luo Wenkao Huang Yunsheng Li |
| author_facet | Lijun Niu Lihong Chen Yanhua Luo Wenkao Huang Yunsheng Li |
| author_sort | Lijun Niu |
| collection | DOAJ |
| description | Abstract Background The objective of this study was to compare the analgesic potency of oxycodone versus morphine after laparoscopic deep infiltrating endometriosis resection. Methods Fifty patients undergoing laparoscopic deep infiltrating endometriosis resection were randomized to receive oxycodone or morphine intravenous-PCA after surgery. The primary outcome was opioid consumption during the 24 h after surgery. Secondary outcomes included time to first request for analgesia, the number of bolus, pain, sedation, nausea, vomiting, respiratory depression, and bradycardia. The prominent pain that caused patients to press the analgesic device was also recorded. Results Oxycodone consumption (14.42 ± 2.83) was less than morphine consumption (20.14 ± 3.83). Compared with the morphine group, the total number of bolus (78 vs 123) was less and the average time to first request for analgesia (97.27 ± 59.79 vs 142.17 ± 51) was longer in the oxycodone group. The incidence of nausea was higher in the morphine group than in the oxycodone group at 0–2 h (45.45% vs 17.19%), 2–4 h (50% vs 17.19%),12–24 h (40.91% vs 13.04%) and 0–24 h (39.17% vs 19.13%). The overall incidence of vomiting was higher in the morphine group (27.27% vs 13.92%). There was no difference in visual analogue scale score, the incidence of respiratory depression, and bradycardia between groups. Of the three types of pain that prompted patients to request analgesia, the incidence of visceral pain was highest (59.9%, P < 0.01). Conclusion Oxycodone was more potent than morphine for analgesia after laparoscopic endometriosis resection, and oxycodone has fewer side effects than morphine. Name of the registry: Chinese Clinical Trial Registry Trial registration number: ChiCTR1900021870 URL of trial registry record: http://www.chictr.org.cn/edit.aspx?pid=35799&htm=4 Date of registration: 2019/3/13 0:00:00 |
| first_indexed | 2024-12-15T00:13:11Z |
| format | Article |
| id | doaj.art-2cbd62802e7f4d2095e6d1ba30b6e0c2 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-12-15T00:13:11Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-2cbd62802e7f4d2095e6d1ba30b6e0c22022-12-21T22:42:30ZengBMCBMC Anesthesiology1471-22532021-07-012111910.1186/s12871-021-01417-3Oxycodone versus morphine for analgesia after laparoscopic endometriosis resectionLijun Niu0Lihong Chen1Yanhua Luo2Wenkao Huang3Yunsheng Li4Department of Anesthesiology, The First Affiliated HospitalDepartment of Anesthesiology, The Six Affiliated HospitalDepartment of Anesthesiology, Zhongshan Ophthalmic Center, Sun Yat-Sen UniversityDepartment of Anesthesiology, Nanfang Hospital, Southern Medical UniversityDepartment of Anesthesiology, The First Affiliated HospitalAbstract Background The objective of this study was to compare the analgesic potency of oxycodone versus morphine after laparoscopic deep infiltrating endometriosis resection. Methods Fifty patients undergoing laparoscopic deep infiltrating endometriosis resection were randomized to receive oxycodone or morphine intravenous-PCA after surgery. The primary outcome was opioid consumption during the 24 h after surgery. Secondary outcomes included time to first request for analgesia, the number of bolus, pain, sedation, nausea, vomiting, respiratory depression, and bradycardia. The prominent pain that caused patients to press the analgesic device was also recorded. Results Oxycodone consumption (14.42 ± 2.83) was less than morphine consumption (20.14 ± 3.83). Compared with the morphine group, the total number of bolus (78 vs 123) was less and the average time to first request for analgesia (97.27 ± 59.79 vs 142.17 ± 51) was longer in the oxycodone group. The incidence of nausea was higher in the morphine group than in the oxycodone group at 0–2 h (45.45% vs 17.19%), 2–4 h (50% vs 17.19%),12–24 h (40.91% vs 13.04%) and 0–24 h (39.17% vs 19.13%). The overall incidence of vomiting was higher in the morphine group (27.27% vs 13.92%). There was no difference in visual analogue scale score, the incidence of respiratory depression, and bradycardia between groups. Of the three types of pain that prompted patients to request analgesia, the incidence of visceral pain was highest (59.9%, P < 0.01). Conclusion Oxycodone was more potent than morphine for analgesia after laparoscopic endometriosis resection, and oxycodone has fewer side effects than morphine. Name of the registry: Chinese Clinical Trial Registry Trial registration number: ChiCTR1900021870 URL of trial registry record: http://www.chictr.org.cn/edit.aspx?pid=35799&htm=4 Date of registration: 2019/3/13 0:00:00https://doi.org/10.1186/s12871-021-01417-3Deep infiltrating endometriosisMorphineOxycodonePostoperative analgesiaVisceral pain |
| spellingShingle | Lijun Niu Lihong Chen Yanhua Luo Wenkao Huang Yunsheng Li Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection BMC Anesthesiology Deep infiltrating endometriosis Morphine Oxycodone Postoperative analgesia Visceral pain |
| title | Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection |
| title_full | Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection |
| title_fullStr | Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection |
| title_full_unstemmed | Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection |
| title_short | Oxycodone versus morphine for analgesia after laparoscopic endometriosis resection |
| title_sort | oxycodone versus morphine for analgesia after laparoscopic endometriosis resection |
| topic | Deep infiltrating endometriosis Morphine Oxycodone Postoperative analgesia Visceral pain |
| url | https://doi.org/10.1186/s12871-021-01417-3 |
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