Antibodies to <i>Porphyromonas gingivalis</i> Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction
There is accumulating data suggesting that periodontitis is associated with increased risk of systemic and autoimmune diseases, including cardiovascular disease, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and there is an unmet need to identify these individuals early. With the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/4/1008 |
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| author | Charlotte de Vries Guillermo Ruacho Elin Kindstedt Barbara Aleksandra Potempa Jan Potempa Björn Klinge Pernilla Lundberg Elisabet Svenungsson Karin Lundberg |
| author_facet | Charlotte de Vries Guillermo Ruacho Elin Kindstedt Barbara Aleksandra Potempa Jan Potempa Björn Klinge Pernilla Lundberg Elisabet Svenungsson Karin Lundberg |
| author_sort | Charlotte de Vries |
| collection | DOAJ |
| description | There is accumulating data suggesting that periodontitis is associated with increased risk of systemic and autoimmune diseases, including cardiovascular disease, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and there is an unmet need to identify these individuals early. With the periodontal bacteria <i>Porphyromonas gingivalis</i> (<i>Pg</i>) as one of the key drivers of periodontitis, we set out to investigate whether antibodies to <i>Pg</i> virulence factor arginine gingipain (Rgp) could serve as a biomarker for periodontitis patients at increased risk of autoimmunity and systemic disease. We measured serum anti-Rgp IgG in three study populations: PAROKRANK (779 individuals with myocardial infarction (MI); 719 controls), where 557 had periodontitis, and 312 were positive for autoantibodies associated with RA/SLE; the PerioGene North pilot (41 periodontitis; 39 controls); and an SLE case/control study (101 SLE; 100 controls). Anti-Rgp IgG levels were increased in severe periodontitis compared to controls (<i>p</i> < 0.0001), in individuals positive for anti-citrullinated protein antibodies (<i>p</i> = 0.04) and anti-dsDNA antibodies (<i>p</i> = 0.035), compared to autoantibody-negative individuals; and in MI patients versus matched controls (<i>p</i> = 0.035). Our data support longitudinal studies addressing the role of anti-Rgp antibodies as biomarkers for periodontitis patients at increased risk of developing autoimmunity linked to RA and SLE, and mechanisms underpinning these associations. |
| first_indexed | 2024-03-09T21:40:54Z |
| format | Article |
| id | doaj.art-2cbe876496d745e8a3b4f4540d148221 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T21:40:54Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2cbe876496d745e8a3b4f4540d1482212023-11-23T20:30:17ZengMDPI AGJournal of Clinical Medicine2077-03832022-02-01114100810.3390/jcm11041008Antibodies to <i>Porphyromonas gingivalis</i> Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial InfarctionCharlotte de Vries0Guillermo Ruacho1Elin Kindstedt2Barbara Aleksandra Potempa3Jan Potempa4Björn Klinge5Pernilla Lundberg6Elisabet Svenungsson7Karin Lundberg8Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, SwedenDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, SwedenDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, SwedenDepartment of Oral Immunology & Infectious Diseases, University of Louisville, Louisville, KY 40202, USADepartment of Oral Immunology & Infectious Diseases, University of Louisville, Louisville, KY 40202, USADivision of Oral Diseases, Department of Dental Medicine, Karolinska Institutet, 171 77 Stockholm, SwedenSection for Molecular Periodontology, Department of Odontology, Umeå University, 901 85 Umeå, SwedenDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, SwedenDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, 171 76 Stockholm, SwedenThere is accumulating data suggesting that periodontitis is associated with increased risk of systemic and autoimmune diseases, including cardiovascular disease, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and there is an unmet need to identify these individuals early. With the periodontal bacteria <i>Porphyromonas gingivalis</i> (<i>Pg</i>) as one of the key drivers of periodontitis, we set out to investigate whether antibodies to <i>Pg</i> virulence factor arginine gingipain (Rgp) could serve as a biomarker for periodontitis patients at increased risk of autoimmunity and systemic disease. We measured serum anti-Rgp IgG in three study populations: PAROKRANK (779 individuals with myocardial infarction (MI); 719 controls), where 557 had periodontitis, and 312 were positive for autoantibodies associated with RA/SLE; the PerioGene North pilot (41 periodontitis; 39 controls); and an SLE case/control study (101 SLE; 100 controls). Anti-Rgp IgG levels were increased in severe periodontitis compared to controls (<i>p</i> < 0.0001), in individuals positive for anti-citrullinated protein antibodies (<i>p</i> = 0.04) and anti-dsDNA antibodies (<i>p</i> = 0.035), compared to autoantibody-negative individuals; and in MI patients versus matched controls (<i>p</i> = 0.035). Our data support longitudinal studies addressing the role of anti-Rgp antibodies as biomarkers for periodontitis patients at increased risk of developing autoimmunity linked to RA and SLE, and mechanisms underpinning these associations.https://www.mdpi.com/2077-0383/11/4/1008<i>Porphyromonas gingivalis</i>autoimmunityrheumatoid arthritissystemic lupus erythematosusmyocardial infarctionarginine gingipains |
| spellingShingle | Charlotte de Vries Guillermo Ruacho Elin Kindstedt Barbara Aleksandra Potempa Jan Potempa Björn Klinge Pernilla Lundberg Elisabet Svenungsson Karin Lundberg Antibodies to <i>Porphyromonas gingivalis</i> Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction Journal of Clinical Medicine <i>Porphyromonas gingivalis</i> autoimmunity rheumatoid arthritis systemic lupus erythematosus myocardial infarction arginine gingipains |
| title | Antibodies to <i>Porphyromonas gingivalis</i> Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction |
| title_full | Antibodies to <i>Porphyromonas gingivalis</i> Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction |
| title_fullStr | Antibodies to <i>Porphyromonas gingivalis</i> Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction |
| title_full_unstemmed | Antibodies to <i>Porphyromonas gingivalis</i> Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction |
| title_short | Antibodies to <i>Porphyromonas gingivalis</i> Are Increased in Patients with Severe Periodontitis, and Associate with Presence of Specific Autoantibodies and Myocardial Infarction |
| title_sort | antibodies to i porphyromonas gingivalis i are increased in patients with severe periodontitis and associate with presence of specific autoantibodies and myocardial infarction |
| topic | <i>Porphyromonas gingivalis</i> autoimmunity rheumatoid arthritis systemic lupus erythematosus myocardial infarction arginine gingipains |
| url | https://www.mdpi.com/2077-0383/11/4/1008 |
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