Unilateral Blurred Vision as the Sole Presenting Symptom of Chronic Lymphocytic Leukemia
Purpose: To describe a case of infiltrative optic neuropathy caused by chronic lymphocytic leukemia. Case Report: A 41-year-old white male presented with painless, blurry vision in the left eye. Examination revealed unilateral optic nerve swelling confirmed by optical coherence tomography (OCT...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Knowledge E
2020-02-01
|
| Series: | Journal of Ophthalmic & Vision Research |
| Subjects: | |
| Online Access: | https://doi.org/10.18502/jovr.v15i1.5958 |
| _version_ | 1811326775058235392 |
|---|---|
| author | Rajesh K. Sharma Kevin Mays |
| author_facet | Rajesh K. Sharma Kevin Mays |
| author_sort | Rajesh K. Sharma |
| collection | DOAJ |
| description | Purpose:
To describe a case of infiltrative optic neuropathy caused by chronic lymphocytic leukemia.
Case Report:
A 41-year-old white male presented with painless, blurry vision in the left eye. Examination revealed unilateral optic nerve swelling confirmed by optical coherence tomography (OCT). Initial workup revealed mild leukocytosis, eventually diagnosed as chronic lymphocytic leukemia (CLL). No other cause of optic neuropathy was identified despite extensive investigation. The patient developed rapidly progressive retinal ganglion cell nerve fiber layer (NFL) atrophy and relative afferent pupillary defect (RAPD) of the left eye despite steroid treatment but stabilized after four cycles of CLL-targeted chemotherapy. Although infiltrative optic neuropathy is well-known in leukemia, presentation with only subtle vision loss is rare. Vision loss usually presents late in leukemic infiltrative optic neuropathy and therefore must be considered in patients with optic disc swelling and leukocytosis.
Conclusion:
When treating CLL, progressive visual decline with coexistent optic neuropathy may warrant chemotherapy. |
| first_indexed | 2024-04-13T14:55:05Z |
| format | Article |
| id | doaj.art-2cbe8ed8451444bb912e896fee53a514 |
| institution | Directory Open Access Journal |
| issn | 2008-322X |
| language | English |
| last_indexed | 2024-04-13T14:55:05Z |
| publishDate | 2020-02-01 |
| publisher | Knowledge E |
| record_format | Article |
| series | Journal of Ophthalmic & Vision Research |
| spelling | doaj.art-2cbe8ed8451444bb912e896fee53a5142022-12-22T02:42:28ZengKnowledge EJournal of Ophthalmic & Vision Research2008-322X2020-02-011510911210.18502/jovr.v15i1.5958Unilateral Blurred Vision as the Sole Presenting Symptom of Chronic Lymphocytic LeukemiaRajesh K. Sharma0Kevin Mays1Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USADepartment of Neurology, University of Mississippi Medical Center, Jackson, MS, USAPurpose: To describe a case of infiltrative optic neuropathy caused by chronic lymphocytic leukemia. Case Report: A 41-year-old white male presented with painless, blurry vision in the left eye. Examination revealed unilateral optic nerve swelling confirmed by optical coherence tomography (OCT). Initial workup revealed mild leukocytosis, eventually diagnosed as chronic lymphocytic leukemia (CLL). No other cause of optic neuropathy was identified despite extensive investigation. The patient developed rapidly progressive retinal ganglion cell nerve fiber layer (NFL) atrophy and relative afferent pupillary defect (RAPD) of the left eye despite steroid treatment but stabilized after four cycles of CLL-targeted chemotherapy. Although infiltrative optic neuropathy is well-known in leukemia, presentation with only subtle vision loss is rare. Vision loss usually presents late in leukemic infiltrative optic neuropathy and therefore must be considered in patients with optic disc swelling and leukocytosis. Conclusion: When treating CLL, progressive visual decline with coexistent optic neuropathy may warrant chemotherapy.https://doi.org/10.18502/jovr.v15i1.5958chronic lymphocytic leukemiaoptic neuropathy |
| spellingShingle | Rajesh K. Sharma Kevin Mays Unilateral Blurred Vision as the Sole Presenting Symptom of Chronic Lymphocytic Leukemia Journal of Ophthalmic & Vision Research chronic lymphocytic leukemia optic neuropathy |
| title | Unilateral Blurred Vision as the Sole Presenting Symptom of Chronic Lymphocytic Leukemia |
| title_full | Unilateral Blurred Vision as the Sole Presenting Symptom of Chronic Lymphocytic Leukemia |
| title_fullStr | Unilateral Blurred Vision as the Sole Presenting Symptom of Chronic Lymphocytic Leukemia |
| title_full_unstemmed | Unilateral Blurred Vision as the Sole Presenting Symptom of Chronic Lymphocytic Leukemia |
| title_short | Unilateral Blurred Vision as the Sole Presenting Symptom of Chronic Lymphocytic Leukemia |
| title_sort | unilateral blurred vision as the sole presenting symptom of chronic lymphocytic leukemia |
| topic | chronic lymphocytic leukemia optic neuropathy |
| url | https://doi.org/10.18502/jovr.v15i1.5958 |
| work_keys_str_mv | AT rajeshksharma unilateralblurredvisionasthesolepresentingsymptomofchroniclymphocyticleukemia AT kevinmays unilateralblurredvisionasthesolepresentingsymptomofchroniclymphocyticleukemia |