Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish
Upstream open reading frames (uORFs) can repress gene expression. Here, Guo-Liang Chew and colleagues use bioinformatics approaches to show that conservation of uORF-mediated translational repression is mediated by sequence features in human, mouse and zebrafish genomes.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11663 |
| _version_ | 1818978012818833408 |
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| author | Guo-Liang Chew Andrea Pauli Alexander F. Schier |
| author_facet | Guo-Liang Chew Andrea Pauli Alexander F. Schier |
| author_sort | Guo-Liang Chew |
| collection | DOAJ |
| description | Upstream open reading frames (uORFs) can repress gene expression. Here, Guo-Liang Chew and colleagues use bioinformatics approaches to show that conservation of uORF-mediated translational repression is mediated by sequence features in human, mouse and zebrafish genomes. |
| first_indexed | 2024-12-20T16:36:52Z |
| format | Article |
| id | doaj.art-2cc05969e6f84064a5e5c7b84f3be8e5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T16:36:52Z |
| publishDate | 2016-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-2cc05969e6f84064a5e5c7b84f3be8e52022-12-21T19:33:08ZengNature PortfolioNature Communications2041-17232016-05-017111010.1038/ncomms11663Conservation of uORF repressiveness and sequence features in mouse, human and zebrafishGuo-Liang Chew0Andrea Pauli1Alexander F. Schier2Department of Molecular and Cellular Biology, Harvard UniversityDepartment of Molecular and Cellular Biology, Harvard UniversityDepartment of Molecular and Cellular Biology, Harvard UniversityUpstream open reading frames (uORFs) can repress gene expression. Here, Guo-Liang Chew and colleagues use bioinformatics approaches to show that conservation of uORF-mediated translational repression is mediated by sequence features in human, mouse and zebrafish genomes.https://doi.org/10.1038/ncomms11663 |
| spellingShingle | Guo-Liang Chew Andrea Pauli Alexander F. Schier Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish Nature Communications |
| title | Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish |
| title_full | Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish |
| title_fullStr | Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish |
| title_full_unstemmed | Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish |
| title_short | Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish |
| title_sort | conservation of uorf repressiveness and sequence features in mouse human and zebrafish |
| url | https://doi.org/10.1038/ncomms11663 |
| work_keys_str_mv | AT guoliangchew conservationofuorfrepressivenessandsequencefeaturesinmousehumanandzebrafish AT andreapauli conservationofuorfrepressivenessandsequencefeaturesinmousehumanandzebrafish AT alexanderfschier conservationofuorfrepressivenessandsequencefeaturesinmousehumanandzebrafish |