The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, Rwanda
<p>Abstract</p> <p>Background</p> <p>The prevalence, incidence and persistence of human papillomavirus (HPV) types in sub-Saharan Africa are not well established. The objectives of the current study are to describe (predictors of) the epidemiology of HPV among high-risk...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-12-01
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| Series: | BMC Infectious Diseases |
| Online Access: | http://www.biomedcentral.com/1471-2334/11/333 |
| _version_ | 1811285347116515328 |
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| author | Veldhuijzen Nienke J Braunstein Sarah L Vyankandondera Joseph Ingabire Chantal Ntirushwa Justin Kestelyn Evelyne Tuijn Coosje Wit Ferdinand W Umutoni Aline Uwineza Mireille Crucitti Tania van de Wijgert Janneke HHM |
| author_facet | Veldhuijzen Nienke J Braunstein Sarah L Vyankandondera Joseph Ingabire Chantal Ntirushwa Justin Kestelyn Evelyne Tuijn Coosje Wit Ferdinand W Umutoni Aline Uwineza Mireille Crucitti Tania van de Wijgert Janneke HHM |
| author_sort | Veldhuijzen Nienke J |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The prevalence, incidence and persistence of human papillomavirus (HPV) types in sub-Saharan Africa are not well established. The objectives of the current study are to describe (predictors of) the epidemiology of HPV among high-risk women in Kigali, Rwanda.</p> <p>Methods</p> <p>HIV-negative, high-risk women were seen quarterly for one year, and once in Year 2. HIV serostatus, clinical, and behavioral information were assessed at each visit, HPV types at Month 6 and Year 2, and other sexually transmitted infections (STI) at selected visits. HPV prevalence was also assessed in HIV-positive, high-risk women.</p> <p>Results</p> <p>Prevalence of any HPV was 47.0% in HIV-negative women (median age 25 years) compared to 72.2% in HIV-positive women (median age 27 years; OR 2.9, 95% CI 1.9-4.6). Among HIV-negative women, cumulative incidence of high-risk (HR)-HPV was 28.0% and persistence 32.0% after a mean period of 16.6 and 16.9 months, respectively. Prior <it>Chlamydia trachomatis </it>and <it>Neisseria gonorrhoeae </it>infection, concurrent low-risk (LR)-HPV infection and incident HSV-2 were associated with HR-HPV prevalence among HIV-negative women; prior <it>C. trachomatis </it>infection and co-infection with LR-HPV and HPV16-related HPV types with HR-HPV acquisition. HPV16-related types were the most prevalent and persistent.</p> <p>Conclusions</p> <p>High HPV prevalence, incidence and persistence were found among high-risk women in Kigali. HPV52 had the highest incidence; and, together with HPV33 and HPV58, were strongly associated with acquisition of other HR-HPV types in HIV-negative women.</p> |
| first_indexed | 2024-04-13T02:43:50Z |
| format | Article |
| id | doaj.art-2cc1a00abcca4ef39b4106fca994ab17 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-13T02:43:50Z |
| publishDate | 2011-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-2cc1a00abcca4ef39b4106fca994ab172022-12-22T03:06:07ZengBMCBMC Infectious Diseases1471-23342011-12-0111133310.1186/1471-2334-11-333The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, RwandaVeldhuijzen Nienke JBraunstein Sarah LVyankandondera JosephIngabire ChantalNtirushwa JustinKestelyn EvelyneTuijn CoosjeWit Ferdinand WUmutoni AlineUwineza MireilleCrucitti Taniavan de Wijgert Janneke HHM<p>Abstract</p> <p>Background</p> <p>The prevalence, incidence and persistence of human papillomavirus (HPV) types in sub-Saharan Africa are not well established. The objectives of the current study are to describe (predictors of) the epidemiology of HPV among high-risk women in Kigali, Rwanda.</p> <p>Methods</p> <p>HIV-negative, high-risk women were seen quarterly for one year, and once in Year 2. HIV serostatus, clinical, and behavioral information were assessed at each visit, HPV types at Month 6 and Year 2, and other sexually transmitted infections (STI) at selected visits. HPV prevalence was also assessed in HIV-positive, high-risk women.</p> <p>Results</p> <p>Prevalence of any HPV was 47.0% in HIV-negative women (median age 25 years) compared to 72.2% in HIV-positive women (median age 27 years; OR 2.9, 95% CI 1.9-4.6). Among HIV-negative women, cumulative incidence of high-risk (HR)-HPV was 28.0% and persistence 32.0% after a mean period of 16.6 and 16.9 months, respectively. Prior <it>Chlamydia trachomatis </it>and <it>Neisseria gonorrhoeae </it>infection, concurrent low-risk (LR)-HPV infection and incident HSV-2 were associated with HR-HPV prevalence among HIV-negative women; prior <it>C. trachomatis </it>infection and co-infection with LR-HPV and HPV16-related HPV types with HR-HPV acquisition. HPV16-related types were the most prevalent and persistent.</p> <p>Conclusions</p> <p>High HPV prevalence, incidence and persistence were found among high-risk women in Kigali. HPV52 had the highest incidence; and, together with HPV33 and HPV58, were strongly associated with acquisition of other HR-HPV types in HIV-negative women.</p>http://www.biomedcentral.com/1471-2334/11/333 |
| spellingShingle | Veldhuijzen Nienke J Braunstein Sarah L Vyankandondera Joseph Ingabire Chantal Ntirushwa Justin Kestelyn Evelyne Tuijn Coosje Wit Ferdinand W Umutoni Aline Uwineza Mireille Crucitti Tania van de Wijgert Janneke HHM The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, Rwanda BMC Infectious Diseases |
| title | The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, Rwanda |
| title_full | The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, Rwanda |
| title_fullStr | The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, Rwanda |
| title_full_unstemmed | The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, Rwanda |
| title_short | The epidemiology of human papillomavirus infection in HIV-positive and HIV-negative high-risk women in Kigali, Rwanda |
| title_sort | epidemiology of human papillomavirus infection in hiv positive and hiv negative high risk women in kigali rwanda |
| url | http://www.biomedcentral.com/1471-2334/11/333 |
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