Stromal Niche Signals That Orchestrate Intestinal RegenerationSummary
Stromal cell populations have a central role in providing signals that support the maintenance, differentiation, and function of the intestinal epithelium. The behavior and fate of epithelial cells is directed by the spatial organization of stromal cells that either sustain stem and progenitor cell...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X24000316 |
| _version_ | 1797259916700811264 |
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| author | Helen E. Abud Shanika L. Amarasinghe Diana Micati Thierry Jardé |
| author_facet | Helen E. Abud Shanika L. Amarasinghe Diana Micati Thierry Jardé |
| author_sort | Helen E. Abud |
| collection | DOAJ |
| description | Stromal cell populations have a central role in providing signals that support the maintenance, differentiation, and function of the intestinal epithelium. The behavior and fate of epithelial cells is directed by the spatial organization of stromal cells that either sustain stem and progenitor cell identity or drive differentiation. A combination of single-cell analyses, mouse models, and organoid coculture assays have provided insight into the diversity of signals delivered by stromal cells. Signaling gradients are established and fine-tuned by the expression of signaling agonists and antagonists along the crypt-villus axis. On epithelial injury, there are disruptions to the abundance and organization of stromal populations. There are also distinct changes in the signals originating from these cells that impact remodeling of the epithelium. How these signals coordinate to mediate epithelial repair or sustain tissue injury in inflammatory bowel diseases is beginning to emerge. Understanding of these processes may lead to opportunities to target stromal cell populations as a strategy to modify disease states. |
| first_indexed | 2024-04-24T23:17:02Z |
| format | Article |
| id | doaj.art-2cc1a3acffd442e9b26977feb353d636 |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-04-24T23:17:02Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-2cc1a3acffd442e9b26977feb353d6362024-03-17T07:54:41ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2024-01-01175679685Stromal Niche Signals That Orchestrate Intestinal RegenerationSummaryHelen E. Abud0Shanika L. Amarasinghe1Diana Micati2Thierry Jardé3Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia; Correspondence Address correspondence to: Helen E. Abud, Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, 19 Innovation Walk, Clayton, Victoria 3800, Australia.Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, AustraliaDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, AustraliaDepartment of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia; Cancer Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, AustraliaStromal cell populations have a central role in providing signals that support the maintenance, differentiation, and function of the intestinal epithelium. The behavior and fate of epithelial cells is directed by the spatial organization of stromal cells that either sustain stem and progenitor cell identity or drive differentiation. A combination of single-cell analyses, mouse models, and organoid coculture assays have provided insight into the diversity of signals delivered by stromal cells. Signaling gradients are established and fine-tuned by the expression of signaling agonists and antagonists along the crypt-villus axis. On epithelial injury, there are disruptions to the abundance and organization of stromal populations. There are also distinct changes in the signals originating from these cells that impact remodeling of the epithelium. How these signals coordinate to mediate epithelial repair or sustain tissue injury in inflammatory bowel diseases is beginning to emerge. Understanding of these processes may lead to opportunities to target stromal cell populations as a strategy to modify disease states.http://www.sciencedirect.com/science/article/pii/S2352345X24000316IntestineNicheRegenerationStem CellsStromal CellsTelocyte |
| spellingShingle | Helen E. Abud Shanika L. Amarasinghe Diana Micati Thierry Jardé Stromal Niche Signals That Orchestrate Intestinal RegenerationSummary Cellular and Molecular Gastroenterology and Hepatology Intestine Niche Regeneration Stem Cells Stromal Cells Telocyte |
| title | Stromal Niche Signals That Orchestrate Intestinal RegenerationSummary |
| title_full | Stromal Niche Signals That Orchestrate Intestinal RegenerationSummary |
| title_fullStr | Stromal Niche Signals That Orchestrate Intestinal RegenerationSummary |
| title_full_unstemmed | Stromal Niche Signals That Orchestrate Intestinal RegenerationSummary |
| title_short | Stromal Niche Signals That Orchestrate Intestinal RegenerationSummary |
| title_sort | stromal niche signals that orchestrate intestinal regenerationsummary |
| topic | Intestine Niche Regeneration Stem Cells Stromal Cells Telocyte |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X24000316 |
| work_keys_str_mv | AT heleneabud stromalnichesignalsthatorchestrateintestinalregenerationsummary AT shanikalamarasinghe stromalnichesignalsthatorchestrateintestinalregenerationsummary AT dianamicati stromalnichesignalsthatorchestrateintestinalregenerationsummary AT thierryjarde stromalnichesignalsthatorchestrateintestinalregenerationsummary |