Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study
Background Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. Methods The clinical and laboratory data of 383 patients with the definite outcome...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-05-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2020.1754383 |
| _version_ | 1797684189376544768 |
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| author | Yanli Liu Wenwu Sun Yanan Guo Liangkai Chen Lijuan Zhang Su Zhao Ding Long Li Yu |
| author_facet | Yanli Liu Wenwu Sun Yanan Guo Liangkai Chen Lijuan Zhang Su Zhao Ding Long Li Yu |
| author_sort | Yanli Liu |
| collection | DOAJ |
| description | Background Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. Methods The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 in the Central Hospital of Wuhan were reviewed. The association between platelet parameters and mortality risk was estimated by utilizing Cox proportional hazard regression models. Results Among the 383 patients, 334 (87.2%) were discharged and survived, and 49 (12.8%) died. Thrombocytopenia at admission was associated with mortality of almost three times as high as that for those without thrombocytopenia (P < 0.05). Cox regression analyses revealed that platelet count was an independent risk factor associated with in-hospital mortality in a dose-dependent manner. An increment of per 50 × 109/L in platelets was associated with a 40% decrease in mortality (hazard ratio: 0.60, 95%CI: 0.43, 0.84). Dynamic changes of platelets were also closely related to death during hospitalization. Conclusions Baseline platelet levels and changes were associated with subsequent mortality. Monitoring platelets during hospitalization may be important in the prognosis of patients with coronavirus disease in 2019. |
| first_indexed | 2024-03-12T00:26:00Z |
| format | Article |
| id | doaj.art-2cc513ed9ea74d9e9fccf86ced5e131a |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:26:00Z |
| publishDate | 2020-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-2cc513ed9ea74d9e9fccf86ced5e131a2023-09-15T10:38:07ZengTaylor & Francis GroupPlatelets0953-71041369-16352020-05-0131449049610.1080/09537104.2020.17543831754383Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort studyYanli Liu0Wenwu Sun1Yanan Guo2Liangkai Chen3Lijuan Zhang4Su Zhao5Ding Long6Li Yu7Tongji Medical College, Huazhong University of Science and TechnologyTongji Medical College, Huazhong University of Science and TechnologyTongji Medical College, Huazhong University of Science and TechnologyHubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyTongji Medical College, Huazhong University of Science and TechnologyThe Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and TechnologyTongji Medical College, Huazhong University of Science and TechnologyTongji Medical College, Huazhong University of Science and TechnologyBackground Thrombocytopenia has been implicated in patients infected with severe acute respiratory syndrome coronavirus 2, while the association of platelet count and changes with subsequent mortality remains unclear. Methods The clinical and laboratory data of 383 patients with the definite outcome by March 1, 2020 in the Central Hospital of Wuhan were reviewed. The association between platelet parameters and mortality risk was estimated by utilizing Cox proportional hazard regression models. Results Among the 383 patients, 334 (87.2%) were discharged and survived, and 49 (12.8%) died. Thrombocytopenia at admission was associated with mortality of almost three times as high as that for those without thrombocytopenia (P < 0.05). Cox regression analyses revealed that platelet count was an independent risk factor associated with in-hospital mortality in a dose-dependent manner. An increment of per 50 × 109/L in platelets was associated with a 40% decrease in mortality (hazard ratio: 0.60, 95%CI: 0.43, 0.84). Dynamic changes of platelets were also closely related to death during hospitalization. Conclusions Baseline platelet levels and changes were associated with subsequent mortality. Monitoring platelets during hospitalization may be important in the prognosis of patients with coronavirus disease in 2019.http://dx.doi.org/10.1080/09537104.2020.1754383cohort studycoronavirus disease 2019mortalityplatelet countsevere acute respiratory syndrome coronavirus 2 |
| spellingShingle | Yanli Liu Wenwu Sun Yanan Guo Liangkai Chen Lijuan Zhang Su Zhao Ding Long Li Yu Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study Platelets cohort study coronavirus disease 2019 mortality platelet count severe acute respiratory syndrome coronavirus 2 |
| title | Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study |
| title_full | Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study |
| title_fullStr | Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study |
| title_full_unstemmed | Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study |
| title_short | Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study |
| title_sort | association between platelet parameters and mortality in coronavirus disease 2019 retrospective cohort study |
| topic | cohort study coronavirus disease 2019 mortality platelet count severe acute respiratory syndrome coronavirus 2 |
| url | http://dx.doi.org/10.1080/09537104.2020.1754383 |
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