Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications
This review examined a collection of studies regarding the molecular properties of some polyene antibiotic molecules as well as their properties in solution and in particular environmental conditions. We also looked into the proposed mechanism of action of polyenes, where membrane properties play a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/12/7/681 |
| _version_ | 1797417060849942528 |
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| author | Tammy Haro-Reyes Lucero Díaz-Peralta Arturo Galván-Hernández Anahi Rodríguez-López Lourdes Rodríguez-Fragoso Iván Ortega-Blake |
| author_facet | Tammy Haro-Reyes Lucero Díaz-Peralta Arturo Galván-Hernández Anahi Rodríguez-López Lourdes Rodríguez-Fragoso Iván Ortega-Blake |
| author_sort | Tammy Haro-Reyes |
| collection | DOAJ |
| description | This review examined a collection of studies regarding the molecular properties of some polyene antibiotic molecules as well as their properties in solution and in particular environmental conditions. We also looked into the proposed mechanism of action of polyenes, where membrane properties play a crucial role. Given the interest in polyene antibiotics as therapeutic agents, we looked into alternative ways of reducing their collateral toxicity, including semi-synthesis of derivatives and new formulations. We follow with studies on the role of membrane structure and, finally, recent developments regarding the most important clinical applications of these compounds. |
| first_indexed | 2024-03-09T06:13:27Z |
| format | Article |
| id | doaj.art-2cc54cfa75c843078dbcbc4672fd07fd |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-09T06:13:27Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-2cc54cfa75c843078dbcbc4672fd07fd2023-12-03T11:55:23ZengMDPI AGMembranes2077-03752022-06-0112768110.3390/membranes12070681Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical ApplicationsTammy Haro-Reyes0Lucero Díaz-Peralta1Arturo Galván-Hernández2Anahi Rodríguez-López3Lourdes Rodríguez-Fragoso4Iván Ortega-Blake5Instituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Av. Universidad s/n, Col. Chamilpa, Cuernavaca 62210, Morelos, MexicoInstituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Av. Universidad s/n, Col. Chamilpa, Cuernavaca 62210, Morelos, MexicoInstituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Av. Universidad s/n, Col. Chamilpa, Cuernavaca 62210, Morelos, MexicoFacultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca 62210, Morelos, MexicoFacultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca 62210, Morelos, MexicoInstituto de Ciencias Físicas, Universidad Nacional Autónoma de México, Av. Universidad s/n, Col. Chamilpa, Cuernavaca 62210, Morelos, MexicoThis review examined a collection of studies regarding the molecular properties of some polyene antibiotic molecules as well as their properties in solution and in particular environmental conditions. We also looked into the proposed mechanism of action of polyenes, where membrane properties play a crucial role. Given the interest in polyene antibiotics as therapeutic agents, we looked into alternative ways of reducing their collateral toxicity, including semi-synthesis of derivatives and new formulations. We follow with studies on the role of membrane structure and, finally, recent developments regarding the most important clinical applications of these compounds.https://www.mdpi.com/2077-0375/12/7/681polyeneschemical propertiesmechanism of actionsemi-synthetic derivativesliposomal formulationmembrane structure |
| spellingShingle | Tammy Haro-Reyes Lucero Díaz-Peralta Arturo Galván-Hernández Anahi Rodríguez-López Lourdes Rodríguez-Fragoso Iván Ortega-Blake Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications Membranes polyenes chemical properties mechanism of action semi-synthetic derivatives liposomal formulation membrane structure |
| title | Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications |
| title_full | Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications |
| title_fullStr | Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications |
| title_full_unstemmed | Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications |
| title_short | Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications |
| title_sort | polyene antibiotics physical chemistry and their effect on lipid membranes impacting biological processes and medical applications |
| topic | polyenes chemical properties mechanism of action semi-synthetic derivatives liposomal formulation membrane structure |
| url | https://www.mdpi.com/2077-0375/12/7/681 |
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