Laparoscopic Splenectomy in Colorectal Cancer Patients with Chemotherapy-Associated Thrombocytopenia due to Hypersplenism
Background: Hypersplenism due to chemotherapy-related liver injury has been associated with severe thrombocytopenia that may preclude continuation of systemic therapy for cancer patients. Patients treated for metastatic colorectal cancer (mCRC) are among the most common patients affected by hyperspl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2012-11-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/345413 |
| _version_ | 1819209977257000960 |
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| author | David A. Litvak Salman Malad Robert A. Wascher Maurie Markman Jiaxin Niu |
| author_facet | David A. Litvak Salman Malad Robert A. Wascher Maurie Markman Jiaxin Niu |
| author_sort | David A. Litvak |
| collection | DOAJ |
| description | Background: Hypersplenism due to chemotherapy-related liver injury has been associated with severe thrombocytopenia that may preclude continuation of systemic therapy for cancer patients. Patients treated for metastatic colorectal cancer (mCRC) are among the most common patients affected by hypersplenism. Cessation of systemic therapy invariably leads to progression of disease. While partial splenic embolization has been employed successfully to reverse the effects of hypersplenism, the role of laparoscopic splenectomy for this problem has not been completely defined. Methods: A retrospective review was conducted of mCRC patients treated with laparoscopic splenectomy at our institution to reverse severe thrombocytopenia due to chemotherapy-related hypersplenism. An endpoint assessed was the ability to resume therapy after splenectomy. Results: Six patients with mCRC and hypersplenism requiring cessation of systemic therapy underwent laparoscopic splenectomy. All (6) patients had a postsurgical platelet count >150 × 103/µl and resumed chemotherapy after surgery. Median platelet count prior to surgery was 66 × 103/µl, and just prior to resuming systemic therapy it was 399.5 × 103/µl. Median spleen size was 14.0 cm. There were no surgical complications. Mean hospital stay was 2.8 days and the median time from surgery to resumption of therapy was 23.5 days. Conclusions: Laparoscopic splenectomy appears to offer selected patients with mCRC the opportunity to resume systemic therapy that otherwise would be discontinued due to thrombocytopenia from hypersplenism. |
| first_indexed | 2024-12-23T06:03:51Z |
| format | Article |
| id | doaj.art-2cc551c95b6c4199ab158622cf8a3b99 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-23T06:03:51Z |
| publishDate | 2012-11-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-2cc551c95b6c4199ab158622cf8a3b992022-12-21T17:57:37ZengKarger PublishersCase Reports in Oncology1662-65752012-11-015360160710.1159/000345413345413Laparoscopic Splenectomy in Colorectal Cancer Patients with Chemotherapy-Associated Thrombocytopenia due to HypersplenismDavid A. LitvakSalman MaladRobert A. WascherMaurie MarkmanJiaxin NiuBackground: Hypersplenism due to chemotherapy-related liver injury has been associated with severe thrombocytopenia that may preclude continuation of systemic therapy for cancer patients. Patients treated for metastatic colorectal cancer (mCRC) are among the most common patients affected by hypersplenism. Cessation of systemic therapy invariably leads to progression of disease. While partial splenic embolization has been employed successfully to reverse the effects of hypersplenism, the role of laparoscopic splenectomy for this problem has not been completely defined. Methods: A retrospective review was conducted of mCRC patients treated with laparoscopic splenectomy at our institution to reverse severe thrombocytopenia due to chemotherapy-related hypersplenism. An endpoint assessed was the ability to resume therapy after splenectomy. Results: Six patients with mCRC and hypersplenism requiring cessation of systemic therapy underwent laparoscopic splenectomy. All (6) patients had a postsurgical platelet count >150 × 103/µl and resumed chemotherapy after surgery. Median platelet count prior to surgery was 66 × 103/µl, and just prior to resuming systemic therapy it was 399.5 × 103/µl. Median spleen size was 14.0 cm. There were no surgical complications. Mean hospital stay was 2.8 days and the median time from surgery to resumption of therapy was 23.5 days. Conclusions: Laparoscopic splenectomy appears to offer selected patients with mCRC the opportunity to resume systemic therapy that otherwise would be discontinued due to thrombocytopenia from hypersplenism.http://www.karger.com/Article/FullText/345413Laparoscopic surgerySplenectomyHypersplenismSplenomegalyThrombocytopeniaColorectal cancerNeoplasm metastasis |
| spellingShingle | David A. Litvak Salman Malad Robert A. Wascher Maurie Markman Jiaxin Niu Laparoscopic Splenectomy in Colorectal Cancer Patients with Chemotherapy-Associated Thrombocytopenia due to Hypersplenism Case Reports in Oncology Laparoscopic surgery Splenectomy Hypersplenism Splenomegaly Thrombocytopenia Colorectal cancer Neoplasm metastasis |
| title | Laparoscopic Splenectomy in Colorectal Cancer Patients with Chemotherapy-Associated Thrombocytopenia due to Hypersplenism |
| title_full | Laparoscopic Splenectomy in Colorectal Cancer Patients with Chemotherapy-Associated Thrombocytopenia due to Hypersplenism |
| title_fullStr | Laparoscopic Splenectomy in Colorectal Cancer Patients with Chemotherapy-Associated Thrombocytopenia due to Hypersplenism |
| title_full_unstemmed | Laparoscopic Splenectomy in Colorectal Cancer Patients with Chemotherapy-Associated Thrombocytopenia due to Hypersplenism |
| title_short | Laparoscopic Splenectomy in Colorectal Cancer Patients with Chemotherapy-Associated Thrombocytopenia due to Hypersplenism |
| title_sort | laparoscopic splenectomy in colorectal cancer patients with chemotherapy associated thrombocytopenia due to hypersplenism |
| topic | Laparoscopic surgery Splenectomy Hypersplenism Splenomegaly Thrombocytopenia Colorectal cancer Neoplasm metastasis |
| url | http://www.karger.com/Article/FullText/345413 |
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