Familial Ovarian Cancer Clusters with Other Cancers
Abstract Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-29888-4 |
| _version_ | 1818998863123447808 |
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| author | Guoqiao Zheng Hongyao Yu Anna Kanerva Asta Försti Kristina Sundquist Kari Hemminki |
| author_facet | Guoqiao Zheng Hongyao Yu Anna Kanerva Asta Försti Kristina Sundquist Kari Hemminki |
| author_sort | Guoqiao Zheng |
| collection | DOAJ |
| description | Abstract Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with (histology-specific) ovarian cancer patients. Eight discordant cancers were associated with ovarian cancer risk, of which family history of breast cancer showed a dose-response (P-trend <0.0001). Conversely, risks of eight types of cancer increased in families with ovarian cancer patients, and dose-responses were shown for risks of liver (P-trend = 0.0083) and breast cancers (P-trend <0.0001) and cancer of unknown primary (P-trend = 0.0157). Some cancers were only associated with histology-specific ovarian cancers, e.g. endometrial cancer was only associated with endometrioid type but with highest significance. Novel associations with virus-linked cancers of the nose and male and female genitals were found. The results suggest that ovarian cancer shares susceptibility with a number of other cancers. This might alert genetic counselors and challenge approaches for gene and gene-environment identification. |
| first_indexed | 2024-12-20T22:08:17Z |
| format | Article |
| id | doaj.art-2cc634ba704c47afa34e40ff5a1dc6f0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-20T22:08:17Z |
| publishDate | 2018-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2cc634ba704c47afa34e40ff5a1dc6f02022-12-21T19:25:13ZengNature PortfolioScientific Reports2045-23222018-08-018111010.1038/s41598-018-29888-4Familial Ovarian Cancer Clusters with Other CancersGuoqiao Zheng0Hongyao Yu1Anna Kanerva2Asta Försti3Kristina Sundquist4Kari Hemminki5Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ)Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ)Cancer Gene Therapy Group, Faculty of Medicine, University of HelsinkiDivision of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ)Center for Primary Health Care Research, Lund University, 205 02Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ)Abstract Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with (histology-specific) ovarian cancer patients. Eight discordant cancers were associated with ovarian cancer risk, of which family history of breast cancer showed a dose-response (P-trend <0.0001). Conversely, risks of eight types of cancer increased in families with ovarian cancer patients, and dose-responses were shown for risks of liver (P-trend = 0.0083) and breast cancers (P-trend <0.0001) and cancer of unknown primary (P-trend = 0.0157). Some cancers were only associated with histology-specific ovarian cancers, e.g. endometrial cancer was only associated with endometrioid type but with highest significance. Novel associations with virus-linked cancers of the nose and male and female genitals were found. The results suggest that ovarian cancer shares susceptibility with a number of other cancers. This might alert genetic counselors and challenge approaches for gene and gene-environment identification.https://doi.org/10.1038/s41598-018-29888-4 |
| spellingShingle | Guoqiao Zheng Hongyao Yu Anna Kanerva Asta Försti Kristina Sundquist Kari Hemminki Familial Ovarian Cancer Clusters with Other Cancers Scientific Reports |
| title | Familial Ovarian Cancer Clusters with Other Cancers |
| title_full | Familial Ovarian Cancer Clusters with Other Cancers |
| title_fullStr | Familial Ovarian Cancer Clusters with Other Cancers |
| title_full_unstemmed | Familial Ovarian Cancer Clusters with Other Cancers |
| title_short | Familial Ovarian Cancer Clusters with Other Cancers |
| title_sort | familial ovarian cancer clusters with other cancers |
| url | https://doi.org/10.1038/s41598-018-29888-4 |
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