Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery
A dual doxorubicin/camptothecin (DOX/CPT) pH-triggered drug delivery mesoporous silica nanoparticle (MSN)-based nano-vehicle has been prepared. In this drug-delivery system (DDS), CPT is loaded inside the pores of the MSNs, while DOX is covalently attached to the surface of an aldehyde-functionalize...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-01-01
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| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2018.1472678 |
| _version_ | 1819012236941721600 |
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| author | Maria C. Llinàs Gabriel Martínez-Edo Anna Cascante Irene Porcar Salvador Borrós David Sánchez-García |
| author_facet | Maria C. Llinàs Gabriel Martínez-Edo Anna Cascante Irene Porcar Salvador Borrós David Sánchez-García |
| author_sort | Maria C. Llinàs |
| collection | DOAJ |
| description | A dual doxorubicin/camptothecin (DOX/CPT) pH-triggered drug delivery mesoporous silica nanoparticle (MSN)-based nano-vehicle has been prepared. In this drug-delivery system (DDS), CPT is loaded inside the pores of the MSNs, while DOX is covalently attached to the surface of an aldehyde-functionalized MSN through a dihydrazide–polyethylene glycol chain. Thus, DOX and the linker act as pH-sensitive gatekeeper. The system is versatile and easy to assemble, not requiring the chemical modification of the drugs. While at physiological conditions the release of the drugs is negligible, at acidic pH a burst release of DOX and a gradual release of CPT take place. In vitro cytotoxicity tests have demonstrated that this DDS can deliver efficiently DOX and CPT for combination therapy. |
| first_indexed | 2024-12-21T01:40:51Z |
| format | Article |
| id | doaj.art-2cc682437f584bf8984c320afd098b47 |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-21T01:40:51Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-2cc682437f584bf8984c320afd098b472022-12-21T19:20:10ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642018-01-012511137114610.1080/10717544.2018.14726781472678Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered deliveryMaria C. Llinàs0Gabriel Martínez-Edo1Anna Cascante2Irene Porcar3Salvador Borrós4David Sánchez-García5Universitat Ramon LlullUniversitat Ramon LlullUniversitat Ramon LlullUniversitat Ramon LlullUniversitat Ramon LlullUniversitat Ramon LlullA dual doxorubicin/camptothecin (DOX/CPT) pH-triggered drug delivery mesoporous silica nanoparticle (MSN)-based nano-vehicle has been prepared. In this drug-delivery system (DDS), CPT is loaded inside the pores of the MSNs, while DOX is covalently attached to the surface of an aldehyde-functionalized MSN through a dihydrazide–polyethylene glycol chain. Thus, DOX and the linker act as pH-sensitive gatekeeper. The system is versatile and easy to assemble, not requiring the chemical modification of the drugs. While at physiological conditions the release of the drugs is negligible, at acidic pH a burst release of DOX and a gradual release of CPT take place. In vitro cytotoxicity tests have demonstrated that this DDS can deliver efficiently DOX and CPT for combination therapy.http://dx.doi.org/10.1080/10717544.2018.1472678mesoporous silica nanoparticlesdual releasedoxorubicincamptothecincombination therapy |
| spellingShingle | Maria C. Llinàs Gabriel Martínez-Edo Anna Cascante Irene Porcar Salvador Borrós David Sánchez-García Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery Drug Delivery mesoporous silica nanoparticles dual release doxorubicin camptothecin combination therapy |
| title | Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery |
| title_full | Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery |
| title_fullStr | Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery |
| title_full_unstemmed | Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery |
| title_short | Preparation of a mesoporous silica-based nano-vehicle for dual DOX/CPT pH-triggered delivery |
| title_sort | preparation of a mesoporous silica based nano vehicle for dual dox cpt ph triggered delivery |
| topic | mesoporous silica nanoparticles dual release doxorubicin camptothecin combination therapy |
| url | http://dx.doi.org/10.1080/10717544.2018.1472678 |
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