A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant
Abstract β‐islet cell transplantation is a promising proposed treatment for type 1 diabetes mellitus (T1DM) which can provide more physiological glucose control when compared to exogenous insulin therapy and reverse secondary consequences of diabetes. Unfortunately, β‐islet cell transplantation is n...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2023-03-01
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| Series: | Nano Select |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/nano.202200147 |
| _version_ | 1811155016600256512 |
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| author | Anessa Puskar Bara Saadah Asad Rauf Szymon R. Kasperek Muhammad Umair |
| author_facet | Anessa Puskar Bara Saadah Asad Rauf Szymon R. Kasperek Muhammad Umair |
| author_sort | Anessa Puskar |
| collection | DOAJ |
| description | Abstract β‐islet cell transplantation is a promising proposed treatment for type 1 diabetes mellitus (T1DM) which can provide more physiological glucose control when compared to exogenous insulin therapy and reverse secondary consequences of diabetes. Unfortunately, β‐islet cell transplantation is not a permanent solution for patients with T1DM as 85–90% of β‐islet recipients return to exogenous insulin treatment within 5 years of the transplant. Despite its lack of success, β‐islet cell transplantation still has potential for the treatment of T1DM and significant work has been done to non‐invasively quantify β‐islet cell concentrations in transplantation to better understand the mechanism of β‐islet cell rejection. While several imaging modalities have been utilized, magnetic resonance imaging (MRI) remains at the forefront of β‐islet cell imaging due to its high resolution and lack of radiation exposure to patients. Several MRI contrast agents have been explored for the imaging of β‐islet cells including superparamagnetic iron oxide nanoparticles (SPIONs), gadolinium‐based contrast agents (GBCA), manganese (II), fluorine‐19, and theranostic agents, with SPIONs being the most extensively studied. In this review, we provide an overview of the history, recent progress, and challenges of MRI in islet transplantation with a focus on the molecular imaging agents used. |
| first_indexed | 2024-04-10T04:27:01Z |
| format | Article |
| id | doaj.art-2cc6bbb41a2746f79eb5f454833012c9 |
| institution | Directory Open Access Journal |
| issn | 2688-4011 |
| language | English |
| last_indexed | 2024-04-10T04:27:01Z |
| publishDate | 2023-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Nano Select |
| spelling | doaj.art-2cc6bbb41a2746f79eb5f454833012c92023-03-10T10:06:07ZengWiley-VCHNano Select2688-40112023-03-014318119110.1002/nano.202200147A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplantAnessa Puskar0Bara Saadah1Asad Rauf2Szymon R. Kasperek3Muhammad Umair4Carle Illinois College of Medicine Urbana‐Champaign Urbana Illinois USACarle Illinois College of Medicine Urbana‐Champaign Urbana Illinois USACarle Illinois College of Medicine Urbana‐Champaign Urbana Illinois USACarle Illinois College of Medicine Urbana‐Champaign Urbana Illinois USADepartment of Radiology Johns Hopkins Baltimore Maryland USAAbstract β‐islet cell transplantation is a promising proposed treatment for type 1 diabetes mellitus (T1DM) which can provide more physiological glucose control when compared to exogenous insulin therapy and reverse secondary consequences of diabetes. Unfortunately, β‐islet cell transplantation is not a permanent solution for patients with T1DM as 85–90% of β‐islet recipients return to exogenous insulin treatment within 5 years of the transplant. Despite its lack of success, β‐islet cell transplantation still has potential for the treatment of T1DM and significant work has been done to non‐invasively quantify β‐islet cell concentrations in transplantation to better understand the mechanism of β‐islet cell rejection. While several imaging modalities have been utilized, magnetic resonance imaging (MRI) remains at the forefront of β‐islet cell imaging due to its high resolution and lack of radiation exposure to patients. Several MRI contrast agents have been explored for the imaging of β‐islet cells including superparamagnetic iron oxide nanoparticles (SPIONs), gadolinium‐based contrast agents (GBCA), manganese (II), fluorine‐19, and theranostic agents, with SPIONs being the most extensively studied. In this review, we provide an overview of the history, recent progress, and challenges of MRI in islet transplantation with a focus on the molecular imaging agents used.https://doi.org/10.1002/nano.202200147islet transplantationmagnetic resonance imagingnon‐invasive imagingpancreatic isletstype 1 diabetes mellitus |
| spellingShingle | Anessa Puskar Bara Saadah Asad Rauf Szymon R. Kasperek Muhammad Umair A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant Nano Select islet transplantation magnetic resonance imaging non‐invasive imaging pancreatic islets type 1 diabetes mellitus |
| title | A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant |
| title_full | A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant |
| title_fullStr | A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant |
| title_full_unstemmed | A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant |
| title_short | A primer on contrast agents for magnetic resonance imaging of post‐procedural and follow‐up imaging of islet cell transplant |
| title_sort | primer on contrast agents for magnetic resonance imaging of post procedural and follow up imaging of islet cell transplant |
| topic | islet transplantation magnetic resonance imaging non‐invasive imaging pancreatic islets type 1 diabetes mellitus |
| url | https://doi.org/10.1002/nano.202200147 |
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