Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells

Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells

Signaling via death receptor family members such as TNF-R1 mediates pleiotropic biological outcomes ranging from inflammation and proliferation to cell death. Pro-survival signaling is mediated via TNF-R1 complex I at the cellular plasma membrane. Cell death induction requires complex IIa/b or necro...

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Bibliographic Details
Main Authors: Jürgen Fritsch, Julia Frankenheim, Lothar Marischen, Timea Vadasz, Anja Troeger, Stefan Rose-John, Dirk Schmidt-Arras, Wulf Schneider-Brachert
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
TNF-R1
ADAM17
cell death
Online Access:https://www.mdpi.com/2073-4409/10/11/3100

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