Chimeric Antigen Receptor T-Cell Therapy Clinical Results in Pediatric and Young Adult B-ALL

Chimeric Antigen Receptor T-Cell Therapy Clinical Results in Pediatric and Young Adult B-ALL

Abstract. Chimeric antigen receptor (CAR)-modified T-cell therapy has revolutionized the care of patients with relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL). Results from clinical trials across multiple institutions report remarkable remission rates with CD19-directed CAR-modif...

Full description

Bibliographic Details
Main Authors:	Amanda M. DiNofia, Shannon L. Maude
Format:	Article
Language:	English
Published:	Wiley 2019-08-01
Series:	HemaSphere
Online Access:	http://journals.lww.com/10.1097/HS9.0000000000000279

Similar Items

Therapies and outcomes following extramedullary relapse of pediatric and young adult ALL after CD19 CAR T-cell therapy
by: Barbara D. Friedes, et al.
Published: (2025-01-01)

SARS-CoV-2 infections in pediatric and young adult recipients of chimeric antigen receptor T-cell therapy: an international registry report
by: Hongyan Liu, et al.
Published: (2023-01-01)

Chimeric antigen receptor T-cell therapy for T-ALL and AML
by: Wenwen Wei, et al.
Published: (2022-11-01)

Anakinra to Mitigate Hemophagocytic Lymphohistiocytosis-Like Toxicity Following Chimeric Antigen Receptor T-cell Therapy in Pediatric B-cell ALL
by: Na Yoon Lee, et al.
Published: (2022-10-01)

Invasive Fungal Disease After Chimeric Antigen Receptor-T Immunotherapy in Adult and Pediatric Patients
by: Paschalis Evangelidis, et al.
Published: (2025-02-01)

Chimeric Antigen Receptor Therapy for B-cell Malignancies
by: David L Porter, Michael Kalos, Zhaohui Zheng, Bruce Levine, Carl June
Published: (2011-01-01)

Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia
by: Hanren Dai, et al.
Published: (2015-11-01)

The Evolution of Chimeric Antigen Receptor T-Cell Therapy in Children, Adolescents and Young Adults with Acute Lymphoblastic Leukemia
by: Dristhi Ragoonanan, et al.
Published: (2022-09-01)

Chimeric Antigen Receptor-T Cell Therapy
by: Jochen Buechner, et al.
Published: (2018-02-01)

Chimeric antigen receptors that trigger phagocytosis
by: Meghan A Morrissey, et al.
Published: (2018-06-01)

The Chimeric Antigen Receptor Detection Toolkit
by: Yifei Hu, et al.
Published: (2020-08-01)

Updates on Chimeric Antigen Receptor T-Cells in Large B-Cell Lymphoma
by: Khalil Saleh, et al.
Published: (2024-12-01)

Chimeric antigen receptor T-cell therapy for aggressive B-cell lymphomas
by: Bei Hu, et al.
Published: (2024-07-01)

Benefits of Chimeric Antigen Receptor T-Cell Therapy for B-Cell Lymphoma
by: Wenyujing Zhou, et al.
Published: (2022-01-01)

Approaches for bridging therapy prior to chimeric antigen receptor T cells for relapsed/refractory acute lymphoblastic B-lineage leukaemia in children and young adults
by: Tobias Feuchtinger, et al.
Published: (2024-02-01)

Chimeric antigen receptor T cells to target CD79b in B-cell lymphomas
by: Michael Green, et al.
Published: (2023-11-01)

Cytomorphology of Chimeric Antigen Receptor T-Cells (CAR-T)
by: Eugenio Galli, et al.
Published: (2021-10-01)

Chimeric Antigen Receptor T-Cell Therapy and Hematopoiesis
by: Bryanna Reinhardt, et al.
Published: (2023-02-01)

Chimeric Antigen Receptor T Cell Therapy in Hematology
by: Pınar Ataca, et al.
Published: (2015-11-01)

A TCR-based Chimeric Antigen Receptor
by: Even Walseng, et al.
Published: (2017-09-01)

Engineering better chimeric antigen receptor T cells
by: Hao Zhang, et al.
Published: (2020-12-01)

Chimeric Antigen Receptor T-Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia
by: Ciprian Tomuleasa, et al.
Published: (2018-02-01)

242 Anti-B7H3 chimeric antigen receptor NK cells for high-risk pediatric brain tumors
by: Ruyan Rahnama, et al.
Published: (2023-11-01)

Chimeric Antigen Receptor-Modified T Cell Therapy in Multiple Myeloma: Beyond B Cell Maturation Antigen
by: Marijke Timmers, et al.
Published: (2019-07-01)

Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide
by: Jan, Max, et al.
Published: (2021)

Unraveling resistance mechanisms in anti-CD19 chimeric antigen receptor-T therapy for B-ALL: a novel in vitro model and insights into target antigen dynamics
by: Hongzhe Li, et al.
Published: (2024-05-01)

Frequency of secondary T-cell lymphoma in chimeric antigen receptor Tcell naïve B-cell lymphoid-lineage cancers is higher than that reported on chimeric antigen receptor T-cell therapy
by: Christian Brieghel, et al.
Published: (2024-10-01)

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity
by: Yan Sun, et al.
Published: (2023-12-01)

Chimeric Antigen Receptors Expand the Repertoire of Antigenic Macromolecules for Cellular Immunity
by: John T. Keane, et al.
Published: (2021-11-01)

Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
by: Xiao Han, et al.
Published: (2019-11-01)

Immune Effector Cell Associated Neurotoxicity (ICANS) in Pediatric and Young Adult Patients Following Chimeric Antigen Receptor (CAR) T-Cell Therapy: Can We Optimize Early Diagnosis?
by: Brandon Douglas Brown, et al.
Published: (2021-03-01)

Chimeric Antigen Receptor-Modified T Cell Immunotherapy for Relapsed and Refractory Adult Burkitt Lymphoma
by: Jiaying Wu, et al.
Published: (2022-05-01)

Advance in chimeric antigen receptor T therapy in autoimmune diseases
by: Xiaolan Ji, et al.
Published: (2025-03-01)

Chimeric antigen receptor T-cell therapy in autoimmune diseases
by: Jie Liu, et al.
Published: (2024-11-01)

CHIMERIC ANTIGEN RECEPTOR T CELLS FOR THE TREATMENT OF MULTIPLE MYELOMA
by: Ugo Testa, et al.
Published: (2024-10-01)

Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors.
by: Hannah Karlsson, et al.
Published: (2015-01-01)

Targeting cardiac fibrosis with chimeric antigen receptor macrophages
by: Zibei Gao, et al.
Published: (2024-08-01)

Empowering chimeric antigen receptor T-cell therapy with CRISPR
by: Xuanzhu Zhou
Published: (2020-04-01)

Strategies to Improve Chimeric Antigen Receptor Therapies for Neuroblastoma
by: Piamsiri Sawaisorn, et al.
Published: (2020-12-01)

Generation of Chimeric Antigen Receptors against Tetraspanin 7
by: Tom Pieper, et al.
Published: (2023-05-01)