Expression and Bioinformatics Analysis of Taurine-Upregulated Gene 1 (TUG1) in Esophageal Squamous Cell Carcinoma (ESCC) Tissue Samples Collected from Patients in Golestan Province, Northeast of Iran
Background and objectives: Esophageal squamous cell carcinoma (ESCC) is the most widespread type of esophageal cancer. LncRNA TUG1 was first identified in a genomic screening study for the treatment of taurine in retinal cells. This study aimed at analyzing TUG1 expression in ESCC tissues collected...
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| Format: | Article |
| Language: | English |
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Golestan University Of Medical Sciences
2020-12-01
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| Series: | Journal of Clinical and Basic Research |
| Subjects: | |
| Online Access: | http://jcbr.goums.ac.ir/article-1-282-en.html |
| _version_ | 1818657404620898304 |
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| author | Yasaman Fateri Eisa Jorjani Abdolvahab Moradi Hosein Sabouri Halime Rahimnia Shabbou Bahramian Zahra Roohineghad Encieh Delshad |
| author_facet | Yasaman Fateri Eisa Jorjani Abdolvahab Moradi Hosein Sabouri Halime Rahimnia Shabbou Bahramian Zahra Roohineghad Encieh Delshad |
| author_sort | Yasaman Fateri |
| collection | DOAJ |
| description | Background and objectives: Esophageal squamous cell carcinoma (ESCC) is the most widespread type of esophageal cancer. LncRNA TUG1 was first identified in a genomic screening study for the treatment of taurine in retinal cells. This study aimed at analyzing TUG1 expression in ESCC tissues collected from an Iranian population of patients. Bioinformatics study was also conducted for better understanding the function of this lnc-RNA.
Methods: We examined the expression of TUG1 in 31 pairs of ESCC tissues and adjacent non-cancerous tissues by qRT-PCR. Bioinformatics analysis was conducted using various databases. Student’s t-test was performed using SPSS software (version 16.0) to evaluate the difference in TUG1 expression between ESCC and adjacent non-cancerous tissues.
Results: TUG1 expression level in ESCC tissues was significantly higher than that in the adjacent non-cancerous tissues (P=0.04).
Conclusion: TUG1 is upregulated in ESCC, which may be related to history of smoking |
| first_indexed | 2024-12-17T03:40:57Z |
| format | Article |
| id | doaj.art-2cceb4b63b81458298f8e7b5fbde2cc7 |
| institution | Directory Open Access Journal |
| issn | 2538-3736 |
| language | English |
| last_indexed | 2024-12-17T03:40:57Z |
| publishDate | 2020-12-01 |
| publisher | Golestan University Of Medical Sciences |
| record_format | Article |
| series | Journal of Clinical and Basic Research |
| spelling | doaj.art-2cceb4b63b81458298f8e7b5fbde2cc72022-12-21T22:05:00ZengGolestan University Of Medical SciencesJournal of Clinical and Basic Research2538-37362020-12-01441726Expression and Bioinformatics Analysis of Taurine-Upregulated Gene 1 (TUG1) in Esophageal Squamous Cell Carcinoma (ESCC) Tissue Samples Collected from Patients in Golestan Province, Northeast of IranYasaman Fateri0Eisa Jorjani1Abdolvahab Moradi2Hosein Sabouri3Halime Rahimnia4Shabbou Bahramian5Zahra Roohineghad6Encieh Delshad7 Department of Biology, Gonbad Kavous University, Gonbad Kavous, Iran Department of Biology, Gonbad Kavous University, Gonbad Kavous, Iran Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran Department of Plant Production, Gonbad Kavous University, Gonbad Kavous, Iran Department of Biology, Gonbad Kavous University, Gonbad Kavous, Iran Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran Background and objectives: Esophageal squamous cell carcinoma (ESCC) is the most widespread type of esophageal cancer. LncRNA TUG1 was first identified in a genomic screening study for the treatment of taurine in retinal cells. This study aimed at analyzing TUG1 expression in ESCC tissues collected from an Iranian population of patients. Bioinformatics study was also conducted for better understanding the function of this lnc-RNA. Methods: We examined the expression of TUG1 in 31 pairs of ESCC tissues and adjacent non-cancerous tissues by qRT-PCR. Bioinformatics analysis was conducted using various databases. Student’s t-test was performed using SPSS software (version 16.0) to evaluate the difference in TUG1 expression between ESCC and adjacent non-cancerous tissues. Results: TUG1 expression level in ESCC tissues was significantly higher than that in the adjacent non-cancerous tissues (P=0.04). Conclusion: TUG1 is upregulated in ESCC, which may be related to history of smokinghttp://jcbr.goums.ac.ir/article-1-282-en.htmlesccezh2gene expressionlong non-coding rnatug1suz12 |
| spellingShingle | Yasaman Fateri Eisa Jorjani Abdolvahab Moradi Hosein Sabouri Halime Rahimnia Shabbou Bahramian Zahra Roohineghad Encieh Delshad Expression and Bioinformatics Analysis of Taurine-Upregulated Gene 1 (TUG1) in Esophageal Squamous Cell Carcinoma (ESCC) Tissue Samples Collected from Patients in Golestan Province, Northeast of Iran Journal of Clinical and Basic Research escc ezh2 gene expression long non-coding rna tug1 suz12 |
| title | Expression and Bioinformatics Analysis of Taurine-Upregulated Gene 1 (TUG1) in Esophageal Squamous Cell Carcinoma (ESCC) Tissue Samples Collected from Patients in Golestan Province, Northeast of Iran |
| title_full | Expression and Bioinformatics Analysis of Taurine-Upregulated Gene 1 (TUG1) in Esophageal Squamous Cell Carcinoma (ESCC) Tissue Samples Collected from Patients in Golestan Province, Northeast of Iran |
| title_fullStr | Expression and Bioinformatics Analysis of Taurine-Upregulated Gene 1 (TUG1) in Esophageal Squamous Cell Carcinoma (ESCC) Tissue Samples Collected from Patients in Golestan Province, Northeast of Iran |
| title_full_unstemmed | Expression and Bioinformatics Analysis of Taurine-Upregulated Gene 1 (TUG1) in Esophageal Squamous Cell Carcinoma (ESCC) Tissue Samples Collected from Patients in Golestan Province, Northeast of Iran |
| title_short | Expression and Bioinformatics Analysis of Taurine-Upregulated Gene 1 (TUG1) in Esophageal Squamous Cell Carcinoma (ESCC) Tissue Samples Collected from Patients in Golestan Province, Northeast of Iran |
| title_sort | expression and bioinformatics analysis of taurine upregulated gene 1 tug1 in esophageal squamous cell carcinoma escc tissue samples collected from patients in golestan province northeast of iran |
| topic | escc ezh2 gene expression long non-coding rna tug1 suz12 |
| url | http://jcbr.goums.ac.ir/article-1-282-en.html |
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