Sedation for Patients with Sepsis: Towards a Personalised Approach
This article looks at the challenges of sedoanalgesia for sepsis patients, and argues for a personalised approach. Sedation is a necessary part of treatment for patients in intensive care to reduce stress and anxiety and improve long-term prognoses. Sepsis patients present particular difficulties as...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/13/12/1641 |
| _version_ | 1797380394687922176 |
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| author | José Miguel Marcos-Vidal Rafael González María Merino Eva Higuera Cristina García |
| author_facet | José Miguel Marcos-Vidal Rafael González María Merino Eva Higuera Cristina García |
| author_sort | José Miguel Marcos-Vidal |
| collection | DOAJ |
| description | This article looks at the challenges of sedoanalgesia for sepsis patients, and argues for a personalised approach. Sedation is a necessary part of treatment for patients in intensive care to reduce stress and anxiety and improve long-term prognoses. Sepsis patients present particular difficulties as they are at increased risk of a wide range of complications, such as multiple organ failure, neurological dysfunction, septic shock, ARDS, abdominal compartment syndrome, vasoplegic syndrome, and myocardial dysfunction. The development of any one of these complications can cause the patient’s rapid deterioration, and each has distinct implications in terms of appropriate and safe forms of sedation. In this way, the present article reviews the sedative and analgesic drugs commonly used in the ICU and, placing special emphasis on their strategic administration in sepsis patients, develops a set of proposals for sedoanalgesia aimed at improving outcomes for this group of patients. These proposals represent a move away from simplistic approaches like avoiding benzodiazepines to more “objective-guided sedation” that accounts for a patient’s principal pathology, as well as any comorbidities, and takes full advantage of the therapeutic arsenal currently available to achieve personalised, patient-centred treatment goals. |
| first_indexed | 2024-03-08T20:36:36Z |
| format | Article |
| id | doaj.art-2ccf43f1ad2f4302b33abb1da970ac30 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-08T20:36:36Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-2ccf43f1ad2f4302b33abb1da970ac302023-12-22T14:19:48ZengMDPI AGJournal of Personalized Medicine2075-44262023-11-011312164110.3390/jpm13121641Sedation for Patients with Sepsis: Towards a Personalised ApproachJosé Miguel Marcos-Vidal0Rafael González1María Merino2Eva Higuera3Cristina García4Department of Anesthesiology and Critical Care, Universitary Hospital of Leon, 24071 Leon, SpainDepartment of Anesthesiology and Critical Care, Universitary Hospital of Leon, 24071 Leon, SpainDepartment of Anesthesiology and Critical Care, Universitary Hospital of Leon, 24071 Leon, SpainDepartment of Anesthesiology and Critical Care, Universitary Hospital of Leon, 24071 Leon, SpainDepartment of Anesthesiology and Critical Care, Universitary Hospital of Leon, 24071 Leon, SpainThis article looks at the challenges of sedoanalgesia for sepsis patients, and argues for a personalised approach. Sedation is a necessary part of treatment for patients in intensive care to reduce stress and anxiety and improve long-term prognoses. Sepsis patients present particular difficulties as they are at increased risk of a wide range of complications, such as multiple organ failure, neurological dysfunction, septic shock, ARDS, abdominal compartment syndrome, vasoplegic syndrome, and myocardial dysfunction. The development of any one of these complications can cause the patient’s rapid deterioration, and each has distinct implications in terms of appropriate and safe forms of sedation. In this way, the present article reviews the sedative and analgesic drugs commonly used in the ICU and, placing special emphasis on their strategic administration in sepsis patients, develops a set of proposals for sedoanalgesia aimed at improving outcomes for this group of patients. These proposals represent a move away from simplistic approaches like avoiding benzodiazepines to more “objective-guided sedation” that accounts for a patient’s principal pathology, as well as any comorbidities, and takes full advantage of the therapeutic arsenal currently available to achieve personalised, patient-centred treatment goals.https://www.mdpi.com/2075-4426/13/12/1641sedationintensive care unitsepsis |
| spellingShingle | José Miguel Marcos-Vidal Rafael González María Merino Eva Higuera Cristina García Sedation for Patients with Sepsis: Towards a Personalised Approach Journal of Personalized Medicine sedation intensive care unit sepsis |
| title | Sedation for Patients with Sepsis: Towards a Personalised Approach |
| title_full | Sedation for Patients with Sepsis: Towards a Personalised Approach |
| title_fullStr | Sedation for Patients with Sepsis: Towards a Personalised Approach |
| title_full_unstemmed | Sedation for Patients with Sepsis: Towards a Personalised Approach |
| title_short | Sedation for Patients with Sepsis: Towards a Personalised Approach |
| title_sort | sedation for patients with sepsis towards a personalised approach |
| topic | sedation intensive care unit sepsis |
| url | https://www.mdpi.com/2075-4426/13/12/1641 |
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