Highly efficient generation of transgenic sheep by lentivirus accompanying the alteration of methylation status.

Highly efficient generation of transgenic sheep by lentivirus accompanying the alteration of methylation status.

BACKGROUND: Low efficiency of gene transfer and silence of transgene expression are the critical factors hampering the development of transgenic livestock. Recently, transfer of recombinant lentivirus has been demonstrated to be an efficient transgene delivery method in various animals. However, the...

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Bibliographic Details
Main Authors: Chenxi Liu, Liqin Wang, Wenrong Li, Xuemei Zhang, Yongzhi Tian, Ning Zhang, Sangang He, Tong Chen, Juncheng Huang, Mingjun Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3558511?pdf=render

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