High-Grade Gliomas in Children—A Multi-Institutional Polish Study
Due to the rarity of high-grade gliomas (HGG) in children, data on this topic are scarce. The study aimed to investigate the long-term results of treatment of children with HGG and to identify factors related to better survival. We performed a retrospective analysis of patients treated for HGG who h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/9/2062 |
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| author | Aleksandra Napieralska Aleksandra Krzywon Agnieszka Mizia-Malarz Joanna Sosna-Zielińska Ewa Pawłowska Małgorzata A. Krawczyk Katarzyna Konat-Bąska Aneta Kaczorowska Anna Dąbrowska Maciej Harat |
| author_facet | Aleksandra Napieralska Aleksandra Krzywon Agnieszka Mizia-Malarz Joanna Sosna-Zielińska Ewa Pawłowska Małgorzata A. Krawczyk Katarzyna Konat-Bąska Aneta Kaczorowska Anna Dąbrowska Maciej Harat |
| author_sort | Aleksandra Napieralska |
| collection | DOAJ |
| description | Due to the rarity of high-grade gliomas (HGG) in children, data on this topic are scarce. The study aimed to investigate the long-term results of treatment of children with HGG and to identify factors related to better survival. We performed a retrospective analysis of patients treated for HGG who had the main tumor located outside the brainstem. The evaluation of factors that correlated with better survival was performed with the Cox proportional-hazard model. Survival was estimated with the Kaplan–Meier method. The study group consisted of 82 consecutive patients. All of them underwent surgery as primary treatment. Chemotherapy was applied in 93% of children with one third treated with temozolomide. After or during the systemic treatment, 79% of them received radiotherapy with a median dose of 54 Gy. Median follow-up was 122 months, and during that time, 59 patients died. One-, 2-, 5-, and 10-year overall survival was 78%, 48%, 30% and 17%, respectively. Patients with radical (R0) resection and temozolomide-based chemotherapy had better overall survival. Progression-free survival was better in patients after R0 resection and radical radiotherapy. The best outcome in HGG patients was observed in patients after R0 resection with immediate postoperative temozolomide-based chemotherapy and radical radiotherapy. |
| first_indexed | 2024-03-10T11:59:40Z |
| format | Article |
| id | doaj.art-2cd1b700f3dc4a98b4ce8b11e7bf8917 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T11:59:40Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-2cd1b700f3dc4a98b4ce8b11e7bf89172023-11-21T17:01:16ZengMDPI AGCancers2072-66942021-04-01139206210.3390/cancers13092062High-Grade Gliomas in Children—A Multi-Institutional Polish StudyAleksandra Napieralska0Aleksandra Krzywon1Agnieszka Mizia-Malarz2Joanna Sosna-Zielińska3Ewa Pawłowska4Małgorzata A. Krawczyk5Katarzyna Konat-Bąska6Aneta Kaczorowska7Anna Dąbrowska8Maciej Harat9Radiotherapy Department, Maria Sklodowska-Curie National Research Institute of Oncology Gliwice Branch, 44-101 Gliwice, PolandDepartment of Biostatistics and Bioinformatics, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-101 Gliwice, PolandDepartment of Pediatrics, Medical University of Silesia, 40-752 Katowice, PolandDepartment of Pediatrics, Medical University of Silesia, 40-752 Katowice, PolandDepartment of Oncology and Radiotherapy, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, PolandDepartment of Pediatrics, Hematology and Oncology, Medical University of Gdansk, 80-210 Gdansk, PolandWroclaw Comprehensive Cancer Center, 53-413 Wrocław, PolandDepartment of Children Oncology and Haematology, Wroclaw Medical University, 53-413 Wrocław, PolandDepartment of Paediatrics, Haematology and Oncology Nicolaus Copernicus University in Toruń Collegium Medicum in Bydgoszcz, 85-094 Bydgoszcz, PolandDepartment of Neurooncology and Radiosurgery, Franciszek Lukaszczyk Memorial Oncology Center, 85-796 Bydgoszcz, PolandDue to the rarity of high-grade gliomas (HGG) in children, data on this topic are scarce. The study aimed to investigate the long-term results of treatment of children with HGG and to identify factors related to better survival. We performed a retrospective analysis of patients treated for HGG who had the main tumor located outside the brainstem. The evaluation of factors that correlated with better survival was performed with the Cox proportional-hazard model. Survival was estimated with the Kaplan–Meier method. The study group consisted of 82 consecutive patients. All of them underwent surgery as primary treatment. Chemotherapy was applied in 93% of children with one third treated with temozolomide. After or during the systemic treatment, 79% of them received radiotherapy with a median dose of 54 Gy. Median follow-up was 122 months, and during that time, 59 patients died. One-, 2-, 5-, and 10-year overall survival was 78%, 48%, 30% and 17%, respectively. Patients with radical (R0) resection and temozolomide-based chemotherapy had better overall survival. Progression-free survival was better in patients after R0 resection and radical radiotherapy. The best outcome in HGG patients was observed in patients after R0 resection with immediate postoperative temozolomide-based chemotherapy and radical radiotherapy.https://www.mdpi.com/2072-6694/13/9/2062high-grade gliomapediatric oncologyradiotherapychemotherapyglioblastoma multiformeanaplastic astrocytoma |
| spellingShingle | Aleksandra Napieralska Aleksandra Krzywon Agnieszka Mizia-Malarz Joanna Sosna-Zielińska Ewa Pawłowska Małgorzata A. Krawczyk Katarzyna Konat-Bąska Aneta Kaczorowska Anna Dąbrowska Maciej Harat High-Grade Gliomas in Children—A Multi-Institutional Polish Study Cancers high-grade glioma pediatric oncology radiotherapy chemotherapy glioblastoma multiforme anaplastic astrocytoma |
| title | High-Grade Gliomas in Children—A Multi-Institutional Polish Study |
| title_full | High-Grade Gliomas in Children—A Multi-Institutional Polish Study |
| title_fullStr | High-Grade Gliomas in Children—A Multi-Institutional Polish Study |
| title_full_unstemmed | High-Grade Gliomas in Children—A Multi-Institutional Polish Study |
| title_short | High-Grade Gliomas in Children—A Multi-Institutional Polish Study |
| title_sort | high grade gliomas in children a multi institutional polish study |
| topic | high-grade glioma pediatric oncology radiotherapy chemotherapy glioblastoma multiforme anaplastic astrocytoma |
| url | https://www.mdpi.com/2072-6694/13/9/2062 |
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