Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment
Emerging evidence suggests that nerves within the tumor microenvironment play a crucial role in regulating angiogenesis. Neurotransmitters and neuropeptides released by nerves can interact with nearby blood vessels and tumor cells, influencing their behavior and modulating the angiogenic response. M...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1284629/full |
| _version_ | 1797324251879964672 |
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| author | Sharif Shalabi Ali Belayachi Bruno Larrivée Bruno Larrivée Bruno Larrivée |
| author_facet | Sharif Shalabi Ali Belayachi Bruno Larrivée Bruno Larrivée Bruno Larrivée |
| author_sort | Sharif Shalabi |
| collection | DOAJ |
| description | Emerging evidence suggests that nerves within the tumor microenvironment play a crucial role in regulating angiogenesis. Neurotransmitters and neuropeptides released by nerves can interact with nearby blood vessels and tumor cells, influencing their behavior and modulating the angiogenic response. Moreover, nerve-derived signals may activate signaling pathways that enhance the production of pro-angiogenic factors within the tumor microenvironment, further supporting blood vessel growth around tumors. The intricate network of communication between neural constituents and the vascular system accentuates the potential of therapeutically targeting neural-mediated pathways as an innovative strategy to modulate tumor angiogenesis and, consequently, neoplastic proliferation. Hereby, we review studies that evaluate the precise molecular interplay and the potential clinical ramifications of manipulating neural elements for the purpose of anti-angiogenic therapeutics within the scope of cancer treatment. |
| first_indexed | 2024-03-08T05:53:24Z |
| format | Article |
| id | doaj.art-2cd1fcada214411795d291bd2067c9e0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T05:53:24Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2cd1fcada214411795d291bd2067c9e02024-02-05T05:02:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.12846291284629Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironmentSharif Shalabi0Ali Belayachi1Bruno Larrivée2Bruno Larrivée3Bruno Larrivée4Maisonneuve-Rosemont Hospital Research Center, Boulevard de l’Assomption, Montréal, QC, CanadaMaisonneuve-Rosemont Hospital Research Center, Boulevard de l’Assomption, Montréal, QC, CanadaMaisonneuve-Rosemont Hospital Research Center, Boulevard de l’Assomption, Montréal, QC, CanadaDepartment of Biochemistry and Molecular Medicine, Montréal, QC, CanadaOphthalmology, Université de Montréal, boul. Édouard-Montpetit, Montréal, QC, CanadaEmerging evidence suggests that nerves within the tumor microenvironment play a crucial role in regulating angiogenesis. Neurotransmitters and neuropeptides released by nerves can interact with nearby blood vessels and tumor cells, influencing their behavior and modulating the angiogenic response. Moreover, nerve-derived signals may activate signaling pathways that enhance the production of pro-angiogenic factors within the tumor microenvironment, further supporting blood vessel growth around tumors. The intricate network of communication between neural constituents and the vascular system accentuates the potential of therapeutically targeting neural-mediated pathways as an innovative strategy to modulate tumor angiogenesis and, consequently, neoplastic proliferation. Hereby, we review studies that evaluate the precise molecular interplay and the potential clinical ramifications of manipulating neural elements for the purpose of anti-angiogenic therapeutics within the scope of cancer treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1284629/fullangiogenesisneurovascular crosstalkgrowth factors (angiogenesis factors)tumor microenvironmenttumorigenesis |
| spellingShingle | Sharif Shalabi Ali Belayachi Bruno Larrivée Bruno Larrivée Bruno Larrivée Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment Frontiers in Immunology angiogenesis neurovascular crosstalk growth factors (angiogenesis factors) tumor microenvironment tumorigenesis |
| title | Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment |
| title_full | Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment |
| title_fullStr | Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment |
| title_full_unstemmed | Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment |
| title_short | Involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment |
| title_sort | involvement of neuronal factors in tumor angiogenesis and the shaping of the cancer microenvironment |
| topic | angiogenesis neurovascular crosstalk growth factors (angiogenesis factors) tumor microenvironment tumorigenesis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1284629/full |
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