Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment
A brain tumor is an uncontrolled cell proliferation, a mass of tissue composed of cells that grow and divide abnormally and appear to be uncontrollable by the processes that normally control normal cells. Approximately 25,690 primary malignant brain tumors are discovered each year, 70% of which orig...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1159131/full |
| _version_ | 1827989176831705088 |
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| author | Monika Kaurav Monika Kaurav Sakina Ruhi Husni Ahmed Al-Goshae Ashok Kumar Jeppu Dhani Ramachandran Ram Kumar Sahu Ashish Kumar Sarkar Jiyauddin Khan Abu Md Ashif Ikbal |
| author_facet | Monika Kaurav Monika Kaurav Sakina Ruhi Husni Ahmed Al-Goshae Ashok Kumar Jeppu Dhani Ramachandran Ram Kumar Sahu Ashish Kumar Sarkar Jiyauddin Khan Abu Md Ashif Ikbal |
| author_sort | Monika Kaurav |
| collection | DOAJ |
| description | A brain tumor is an uncontrolled cell proliferation, a mass of tissue composed of cells that grow and divide abnormally and appear to be uncontrollable by the processes that normally control normal cells. Approximately 25,690 primary malignant brain tumors are discovered each year, 70% of which originate in glial cells. It has been observed that the blood-brain barrier (BBB) limits the distribution of drugs into the tumour environment, which complicates the oncological therapy of malignant brain tumours. Numerous studies have found that nanocarriers have demonstrated significant therapeutic efficacy in brain diseases. This review, based on a non-systematic search of the existing literature, provides an update on the existing knowledge of the types of dendrimers, synthesis methods, and mechanisms of action in relation to brain tumours. It also discusses the use of dendrimers in the diagnosis and treatment of brain tumours and the future possibilities of dendrimers. Dendrimers are of particular interest in the diagnosis and treatment of brain tumours because they can transport biochemical agents across the BBB to the tumour and into the brain after systemic administration. Dendrimers are being used to develop novel therapeutics such as prolonged release of drugs, immunotherapy, and antineoplastic effects. The use of PAMAM, PPI, PLL and surface engineered dendrimers has proven revolutionary in the effective diagnosis and treatment of brain tumours. |
| first_indexed | 2024-04-10T00:15:13Z |
| format | Article |
| id | doaj.art-2cd4210bf8af4f7aba7a9439df959ed8 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T00:15:13Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2cd4210bf8af4f7aba7a9439df959ed82023-03-16T05:16:21ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-03-011410.3389/fphar.2023.11591311159131Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatmentMonika Kaurav0Monika Kaurav1Sakina Ruhi2Husni Ahmed Al-Goshae3Ashok Kumar Jeppu4Dhani Ramachandran5Ram Kumar Sahu6Ashish Kumar Sarkar7Jiyauddin Khan8Abu Md Ashif Ikbal9Department of Pharmaceutics, KIET Group of Institutions (KIET School of Pharmacy), Delhi NCR, Ghaziabad, IndiaDr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh, IndiaDepartment of Biochemistry, IMS, Management and Science University, University Drive, Shah Alam, Selangor, MalaysiaDepartment of Anantomy, IMS, Management and Science University, University Drive, Shah Alam, Selangor, MalaysiaDepartment of Biochemistry, IMS, Management and Science University, University Drive, Shah Alam, Selangor, MalaysiaDepartment of Pathology, IMS, Management and Science University, University Drive, Shah Alam, Selangor, MalaysiaDepartment of Pharmaceutical Sciences, Hemvati Nandan Bahuguna Garhwal University (A Central University), Chauras Campus, Tehri Garhwal, Uttarakhand, IndiaSchool of Pharmacy, YBN University, Ranchi, Jharkhand, IndiaSchool of Pharmacy, Management and Science University, Shah Alam, Selangor, MalaysiaDepartment of Pharmaceutical Sciences, Assam University (A Central University), Silchar, Assam, IndiaA brain tumor is an uncontrolled cell proliferation, a mass of tissue composed of cells that grow and divide abnormally and appear to be uncontrollable by the processes that normally control normal cells. Approximately 25,690 primary malignant brain tumors are discovered each year, 70% of which originate in glial cells. It has been observed that the blood-brain barrier (BBB) limits the distribution of drugs into the tumour environment, which complicates the oncological therapy of malignant brain tumours. Numerous studies have found that nanocarriers have demonstrated significant therapeutic efficacy in brain diseases. This review, based on a non-systematic search of the existing literature, provides an update on the existing knowledge of the types of dendrimers, synthesis methods, and mechanisms of action in relation to brain tumours. It also discusses the use of dendrimers in the diagnosis and treatment of brain tumours and the future possibilities of dendrimers. Dendrimers are of particular interest in the diagnosis and treatment of brain tumours because they can transport biochemical agents across the BBB to the tumour and into the brain after systemic administration. Dendrimers are being used to develop novel therapeutics such as prolonged release of drugs, immunotherapy, and antineoplastic effects. The use of PAMAM, PPI, PLL and surface engineered dendrimers has proven revolutionary in the effective diagnosis and treatment of brain tumours.https://www.frontiersin.org/articles/10.3389/fphar.2023.1159131/fulldendrimersbrain tumorbrain tumor imagingbrain targetingtheranostics |
| spellingShingle | Monika Kaurav Monika Kaurav Sakina Ruhi Husni Ahmed Al-Goshae Ashok Kumar Jeppu Dhani Ramachandran Ram Kumar Sahu Ashish Kumar Sarkar Jiyauddin Khan Abu Md Ashif Ikbal Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment Frontiers in Pharmacology dendrimers brain tumor brain tumor imaging brain targeting theranostics |
| title | Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment |
| title_full | Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment |
| title_fullStr | Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment |
| title_full_unstemmed | Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment |
| title_short | Dendrimer: An update on recent developments and future opportunities for the brain tumors diagnosis and treatment |
| title_sort | dendrimer an update on recent developments and future opportunities for the brain tumors diagnosis and treatment |
| topic | dendrimers brain tumor brain tumor imaging brain targeting theranostics |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1159131/full |
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