Diabetic kidney disease: Is there a non-albuminuric phenotype in type 2 diabetic patients?
Background: Albuminuria was widely considered as the first clinical sign of diabetic kidney disease (DKD), which is why it has traditionally been used as a screening test for DKD. However, increasing evidence has shown that a significant number of type 2 diabetes mellitus (DM) patients have a decrea...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Elsevier
2016-09-01
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| Series: | Nefrología |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0211699516300364 |
| _version_ | 1811259579818835968 |
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| author | Ivo Laranjinha Patrícia Matias Sofia Mateus Filipa Aguiar Patrícia Pereira Miguel Perneta Santos Rui Costa Ana Lourenço José Guia José Diogo Barata Luís Campos |
| author_facet | Ivo Laranjinha Patrícia Matias Sofia Mateus Filipa Aguiar Patrícia Pereira Miguel Perneta Santos Rui Costa Ana Lourenço José Guia José Diogo Barata Luís Campos |
| author_sort | Ivo Laranjinha |
| collection | DOAJ |
| description | Background: Albuminuria was widely considered as the first clinical sign of diabetic kidney disease (DKD), which is why it has traditionally been used as a screening test for DKD. However, increasing evidence has shown that a significant number of type 2 diabetes mellitus (DM) patients have a decreased glomerular filtration rate (GFR) without significant albuminuria, known as non-albuminuric DKD (NA-DKD). The aim of this study was to determine the prevalence and the demographic and clinical characteristics of patients with NA-DKD.
Methods: This was a 1-year retrospective study that included 146 type 2 diabetic patients with GFR < 75 mL/min followed-up in a diabetes outpatient department. Patients were divided into two groups according to their ACR status – NA-DKD and albuminuric DKD (A-DKD).
Results: Of the 146 patients included in the study, 53.4% had A-DKD and 46.6% had NA-DKD. According to the multivariable analysis performed, patients with NA-DKD tended to be older (p = 0.021), female (p = 0.045) and with a lower GFR (p = 0.004) than A-DKD patients.
There was no difference between the groups in terms of body mass index, metabolic control of DM, duration of DM diagnosis and prevalence of metabolic syndrome.
Conclusions: The majority of patients with DKD had albuminuria, but a significant proportion had a non-albuminuric phenotype (46.6% in this population). These patients exhibit distinct clinical features that could have screening, therapeutic and prognosis implications. |
| first_indexed | 2024-04-12T18:33:46Z |
| format | Article |
| id | doaj.art-2cd4e8ea05944dd4830a66b40e22f8c5 |
| institution | Directory Open Access Journal |
| issn | 0211-6995 |
| language | Spanish |
| last_indexed | 2024-04-12T18:33:46Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Nefrología |
| spelling | doaj.art-2cd4e8ea05944dd4830a66b40e22f8c52022-12-22T03:20:59ZspaElsevierNefrología0211-69952016-09-0136550350910.1016/j.nefro.2016.03.025Diabetic kidney disease: Is there a non-albuminuric phenotype in type 2 diabetic patients?Ivo Laranjinha0Patrícia Matias1Sofia Mateus2Filipa Aguiar3Patrícia Pereira4Miguel Perneta Santos5Rui Costa6Ana Lourenço7José Guia8José Diogo Barata9Luís Campos10Nephrology Department, Hospital de Santa Cruz, Lisbon, PortugalNephrology Department, Hospital de Santa Cruz, Lisbon, PortugalInternal Medicine Department, Hospital São Francisco Xavier, Lisbon, PortugalInternal Medicine Department, Hospital São Francisco Xavier, Lisbon, PortugalInternal Medicine Department, Hospital São Francisco Xavier, Lisbon, PortugalInternal Medicine Department, Hospital São Francisco Xavier, Lisbon, PortugalInternal Medicine Department, Hospital São Francisco Xavier, Lisbon, PortugalInternal Medicine Department, Hospital São Francisco Xavier, Lisbon, PortugalInternal Medicine Department, Hospital São Francisco Xavier, Lisbon, PortugalNephrology Department, Hospital de Santa Cruz, Lisbon, PortugalInternal Medicine Department, Hospital São Francisco Xavier, Lisbon, PortugalBackground: Albuminuria was widely considered as the first clinical sign of diabetic kidney disease (DKD), which is why it has traditionally been used as a screening test for DKD. However, increasing evidence has shown that a significant number of type 2 diabetes mellitus (DM) patients have a decreased glomerular filtration rate (GFR) without significant albuminuria, known as non-albuminuric DKD (NA-DKD). The aim of this study was to determine the prevalence and the demographic and clinical characteristics of patients with NA-DKD. Methods: This was a 1-year retrospective study that included 146 type 2 diabetic patients with GFR < 75 mL/min followed-up in a diabetes outpatient department. Patients were divided into two groups according to their ACR status – NA-DKD and albuminuric DKD (A-DKD). Results: Of the 146 patients included in the study, 53.4% had A-DKD and 46.6% had NA-DKD. According to the multivariable analysis performed, patients with NA-DKD tended to be older (p = 0.021), female (p = 0.045) and with a lower GFR (p = 0.004) than A-DKD patients. There was no difference between the groups in terms of body mass index, metabolic control of DM, duration of DM diagnosis and prevalence of metabolic syndrome. Conclusions: The majority of patients with DKD had albuminuria, but a significant proportion had a non-albuminuric phenotype (46.6% in this population). These patients exhibit distinct clinical features that could have screening, therapeutic and prognosis implications.http://www.sciencedirect.com/science/article/pii/S0211699516300364Chronic kidney diseaseType 2 diabetesNon-albuminuria |
| spellingShingle | Ivo Laranjinha Patrícia Matias Sofia Mateus Filipa Aguiar Patrícia Pereira Miguel Perneta Santos Rui Costa Ana Lourenço José Guia José Diogo Barata Luís Campos Diabetic kidney disease: Is there a non-albuminuric phenotype in type 2 diabetic patients? Nefrología Chronic kidney disease Type 2 diabetes Non-albuminuria |
| title | Diabetic kidney disease: Is there a non-albuminuric phenotype in type 2 diabetic patients? |
| title_full | Diabetic kidney disease: Is there a non-albuminuric phenotype in type 2 diabetic patients? |
| title_fullStr | Diabetic kidney disease: Is there a non-albuminuric phenotype in type 2 diabetic patients? |
| title_full_unstemmed | Diabetic kidney disease: Is there a non-albuminuric phenotype in type 2 diabetic patients? |
| title_short | Diabetic kidney disease: Is there a non-albuminuric phenotype in type 2 diabetic patients? |
| title_sort | diabetic kidney disease is there a non albuminuric phenotype in type 2 diabetic patients |
| topic | Chronic kidney disease Type 2 diabetes Non-albuminuria |
| url | http://www.sciencedirect.com/science/article/pii/S0211699516300364 |
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