Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life
Abstract To assess the dynamics of human papillomavirus (HPV) serology, we analyzed HPV6-,11-,16-,18-, and 45 antibodies in infants during the first 36 months of their life. Serial serum samples of 276/327 mother–child pairs were collected at baseline (mothers) and at months 1, 2, 6, 12, 24 and 36 (...
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| Format: | Article |
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Nature Portfolio
2022-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-06343-z |
| _version_ | 1819277000916860928 |
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| author | Stina Syrjänen Tim Waterboer Marjut Rintala Michael Pawlita Kari Syrjänen Karolina Louvanto Seija Grenman |
| author_facet | Stina Syrjänen Tim Waterboer Marjut Rintala Michael Pawlita Kari Syrjänen Karolina Louvanto Seija Grenman |
| author_sort | Stina Syrjänen |
| collection | DOAJ |
| description | Abstract To assess the dynamics of human papillomavirus (HPV) serology, we analyzed HPV6-,11-,16-,18-, and 45 antibodies in infants during the first 36 months of their life. Serial serum samples of 276/327 mother–child pairs were collected at baseline (mothers) and at months 1, 2, 6, 12, 24 and 36 (offspring), and tested for HPVL1-antibodies using the GST-L1 assay. Concordance between maternal and infant HPV-antibody levels remained high until month-6 (p < = 0.001), indicating maternal antibody transfer. At 1 month, 40–62% of the infants tested seropositive to any of the 5 HPV-types. Between 1–3 years of age, 53% (58/109) of the children born to HPV-seronegative mothers tested HPV-seropositive. Times to positive seroconversion varied between13.4 and 18.7 months, and times to negative seroconversion (decay) between 8.5 and 9.9 months. Significant independent predictors of infants’ seroconversion to LR-HPV were hand warts and mother’s history of oral warts and seroconversion to LR-HPV. No predictors of seroconversion to HR-HPV were identified. Maternal HPV-IgG-antibodies are transferred to her offspring and remain detectable for 6 months, corroborating the IgG molecule’s half-life. Seroconversion to HPV-genotypes 6, 11, 16 and 18 was confirmed among children born to HPV-seronegative mothers, implicating an immune response to these HPV-genotypes during early infancy. |
| first_indexed | 2024-12-23T23:49:10Z |
| format | Article |
| id | doaj.art-2cd5198956ae4429ac3abb4909e1db06 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-23T23:49:10Z |
| publishDate | 2022-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2cd5198956ae4429ac3abb4909e1db062022-12-21T17:25:26ZengNature PortfolioScientific Reports2045-23222022-02-0112111110.1038/s41598-022-06343-zMaternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of lifeStina Syrjänen0Tim Waterboer1Marjut Rintala2Michael Pawlita3Kari Syrjänen4Karolina Louvanto5Seija Grenman6Department of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of TurkuDepartment of Genome Modifications and Carcinogenesis, Infection and Cancer Program, German Cancer Research Center (DKFZ)Department of Obstetrics and Gynecology, University of Turku, Turku University HospitalDepartment of Genome Modifications and Carcinogenesis, Infection and Cancer Program, German Cancer Research Center (DKFZ)Department of Clinical Research, Biohit OyjDepartment of Oral Pathology, Institute of Dentistry, Faculty of Medicine, University of TurkuDepartment of Obstetrics and Gynecology, University of Turku, Turku University HospitalAbstract To assess the dynamics of human papillomavirus (HPV) serology, we analyzed HPV6-,11-,16-,18-, and 45 antibodies in infants during the first 36 months of their life. Serial serum samples of 276/327 mother–child pairs were collected at baseline (mothers) and at months 1, 2, 6, 12, 24 and 36 (offspring), and tested for HPVL1-antibodies using the GST-L1 assay. Concordance between maternal and infant HPV-antibody levels remained high until month-6 (p < = 0.001), indicating maternal antibody transfer. At 1 month, 40–62% of the infants tested seropositive to any of the 5 HPV-types. Between 1–3 years of age, 53% (58/109) of the children born to HPV-seronegative mothers tested HPV-seropositive. Times to positive seroconversion varied between13.4 and 18.7 months, and times to negative seroconversion (decay) between 8.5 and 9.9 months. Significant independent predictors of infants’ seroconversion to LR-HPV were hand warts and mother’s history of oral warts and seroconversion to LR-HPV. No predictors of seroconversion to HR-HPV were identified. Maternal HPV-IgG-antibodies are transferred to her offspring and remain detectable for 6 months, corroborating the IgG molecule’s half-life. Seroconversion to HPV-genotypes 6, 11, 16 and 18 was confirmed among children born to HPV-seronegative mothers, implicating an immune response to these HPV-genotypes during early infancy.https://doi.org/10.1038/s41598-022-06343-z |
| spellingShingle | Stina Syrjänen Tim Waterboer Marjut Rintala Michael Pawlita Kari Syrjänen Karolina Louvanto Seija Grenman Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life Scientific Reports |
| title | Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life |
| title_full | Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life |
| title_fullStr | Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life |
| title_full_unstemmed | Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life |
| title_short | Maternal HPV-antibodies and seroconversion to HPV in children during the first 3 years of life |
| title_sort | maternal hpv antibodies and seroconversion to hpv in children during the first 3 years of life |
| url | https://doi.org/10.1038/s41598-022-06343-z |
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