Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion

Alpha-cell paracrine signaling in the regulation of beta-cell insulin secretion

As an incretin hormone, glucagon-like peptide 1 (GLP-1) lowers blood glucose levels by enhancing glucose-stimulated insulin secretion from pancreatic beta-cells. Therapies targeting the GLP-1 receptor (GLP-1R) use the classical incretin model as a physiological framework in which GLP-1 secreted from...

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Bibliographic Details
Main Authors: Marlena M. Holter, Mridusmita Saikia, Bethany P. Cummings
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
alpha-cell
beta-cell
paracrine signaling
GLP-1
glucagon
insulin
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.934775/full

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