Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials
Antimicrobial peptides (AMPs) constitute a promising tool in the development of novel therapeutic agents useful in a wide range of bacterial and fungal infections. Among the modifications improving pharmacokinetic and pharmacodynamic characteristics of natural AMPs, an important role is played by li...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/23/8944 |
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| author | Izabela Małuch Oktawian Stachurski Paulina Kosikowska-Adamus Marta Makowska Marta Bauer Dariusz Wyrzykowski Aleksandra Hać Wojciech Kamysz Milena Deptuła Michał Pikuła Emilia Sikorska |
| author_facet | Izabela Małuch Oktawian Stachurski Paulina Kosikowska-Adamus Marta Makowska Marta Bauer Dariusz Wyrzykowski Aleksandra Hać Wojciech Kamysz Milena Deptuła Michał Pikuła Emilia Sikorska |
| author_sort | Izabela Małuch |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) constitute a promising tool in the development of novel therapeutic agents useful in a wide range of bacterial and fungal infections. Among the modifications improving pharmacokinetic and pharmacodynamic characteristics of natural AMPs, an important role is played by lipidation. This study focuses on the newly designed and synthesized lipopeptides containing multiple Lys residues or their shorter homologues with palmitic acid (C<sub>16</sub>) attached to the side chain of a residue located in the center of the peptide sequence. The approach resulted in the development of lipopeptides representing a model of surfactants with two polar headgroups. The aim of this study is to explain how variations in the length of the peptide chain or the hydrocarbon side chain of an amino acid residue modified with C<sub>16</sub>, affect biological functions of lipopeptides, their self-assembling propensity, and their mode of action. |
| first_indexed | 2024-03-10T14:34:42Z |
| format | Article |
| id | doaj.art-2cd53b98d72744ef8b5398c4d63b9fc0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:34:42Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2cd53b98d72744ef8b5398c4d63b9fc02023-11-20T22:16:21ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012123894410.3390/ijms21238944Double-Headed Cationic Lipopeptides: An Emerging Class of AntimicrobialsIzabela Małuch0Oktawian Stachurski1Paulina Kosikowska-Adamus2Marta Makowska3Marta Bauer4Dariusz Wyrzykowski5Aleksandra Hać6Wojciech Kamysz7Milena Deptuła8Michał Pikuła9Emilia Sikorska10Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandFaculty of Pharmacy, Medicinal University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, PolandFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandFaculty of Biology, University of Gdansk, Str. 59, 80-308 Gdansk, PolandFaculty of Pharmacy, Medicinal University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdansk, PolandLaboratory of Tissue Engineering and Regenerative Medicine, Department of Embryology, Faculty of Medicine, Medical University of Gdansk, Dębinki 1, 80-211 Gdańsk, PolandLaboratory of Tissue Engineering and Regenerative Medicine, Department of Embryology, Faculty of Medicine, Medical University of Gdansk, Dębinki 1, 80-211 Gdańsk, PolandFaculty of Chemistry, University of Gdansk, Wita Stwosza 63, 80-308 Gdansk, PolandAntimicrobial peptides (AMPs) constitute a promising tool in the development of novel therapeutic agents useful in a wide range of bacterial and fungal infections. Among the modifications improving pharmacokinetic and pharmacodynamic characteristics of natural AMPs, an important role is played by lipidation. This study focuses on the newly designed and synthesized lipopeptides containing multiple Lys residues or their shorter homologues with palmitic acid (C<sub>16</sub>) attached to the side chain of a residue located in the center of the peptide sequence. The approach resulted in the development of lipopeptides representing a model of surfactants with two polar headgroups. The aim of this study is to explain how variations in the length of the peptide chain or the hydrocarbon side chain of an amino acid residue modified with C<sub>16</sub>, affect biological functions of lipopeptides, their self-assembling propensity, and their mode of action.https://www.mdpi.com/1422-0067/21/23/8944peptide-lipid conjugatedouble-headed lipopeptidecationic lipopeptideself-assemblyantimicrobial agent |
| spellingShingle | Izabela Małuch Oktawian Stachurski Paulina Kosikowska-Adamus Marta Makowska Marta Bauer Dariusz Wyrzykowski Aleksandra Hać Wojciech Kamysz Milena Deptuła Michał Pikuła Emilia Sikorska Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials International Journal of Molecular Sciences peptide-lipid conjugate double-headed lipopeptide cationic lipopeptide self-assembly antimicrobial agent |
| title | Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials |
| title_full | Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials |
| title_fullStr | Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials |
| title_full_unstemmed | Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials |
| title_short | Double-Headed Cationic Lipopeptides: An Emerging Class of Antimicrobials |
| title_sort | double headed cationic lipopeptides an emerging class of antimicrobials |
| topic | peptide-lipid conjugate double-headed lipopeptide cationic lipopeptide self-assembly antimicrobial agent |
| url | https://www.mdpi.com/1422-0067/21/23/8944 |
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