Major Constituents From Brucea javanica and Their Pharmacological Actions
Brucea javanica (Ya-dan-zi in Chinese) is a well-known Chinese herbal medicine, which is traditionally used in Chinese medicine for the treatment of intestinal inflammation, diarrhea, malaria, and cancer. The formulation of the oil (Brucea javanica oil) has been widely used to treat various types of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.853119/full |
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| author | Juan Zhang Hong-Xi Xu Yao-Xing Dou Qiong-Hui Huang Yan-Fang Xian Zhi-Xiu Lin Zhi-Xiu Lin |
| author_facet | Juan Zhang Hong-Xi Xu Yao-Xing Dou Qiong-Hui Huang Yan-Fang Xian Zhi-Xiu Lin Zhi-Xiu Lin |
| author_sort | Juan Zhang |
| collection | DOAJ |
| description | Brucea javanica (Ya-dan-zi in Chinese) is a well-known Chinese herbal medicine, which is traditionally used in Chinese medicine for the treatment of intestinal inflammation, diarrhea, malaria, and cancer. The formulation of the oil (Brucea javanica oil) has been widely used to treat various types of cancer. It has also been found that B. javanica is rich in chemical constituents, including quassinoids, triterpenes, alkaloids and flavonoids. Pharmacological studies have revealed that chemical compounds derived from B. javanica exhibit multiple bioactivities, such as anti-cancer, anti-bacterial, anti-diabetic, and others. This review provides a comprehensive summary on the pharmacological properties of the main chemical constituents presented in B. javanica and their underlying molecular mechanisms. Moreover, the review will also provide scientific references for further research and development of B. javanica and its chemical constituents into novel pharmaceutical products for disease management. |
| first_indexed | 2024-12-14T05:34:03Z |
| format | Article |
| id | doaj.art-2cd6049913b347d591221beef7471121 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-14T05:34:03Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2cd6049913b347d591221beef74711212022-12-21T23:15:14ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-03-011310.3389/fphar.2022.853119853119Major Constituents From Brucea javanica and Their Pharmacological ActionsJuan Zhang0Hong-Xi Xu1Yao-Xing Dou2Qiong-Hui Huang3Yan-Fang Xian4Zhi-Xiu Lin5Zhi-Xiu Lin6School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, ChinaSchool of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, ChinaSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, ChinaHong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Shatin, ChinaBrucea javanica (Ya-dan-zi in Chinese) is a well-known Chinese herbal medicine, which is traditionally used in Chinese medicine for the treatment of intestinal inflammation, diarrhea, malaria, and cancer. The formulation of the oil (Brucea javanica oil) has been widely used to treat various types of cancer. It has also been found that B. javanica is rich in chemical constituents, including quassinoids, triterpenes, alkaloids and flavonoids. Pharmacological studies have revealed that chemical compounds derived from B. javanica exhibit multiple bioactivities, such as anti-cancer, anti-bacterial, anti-diabetic, and others. This review provides a comprehensive summary on the pharmacological properties of the main chemical constituents presented in B. javanica and their underlying molecular mechanisms. Moreover, the review will also provide scientific references for further research and development of B. javanica and its chemical constituents into novel pharmaceutical products for disease management.https://www.frontiersin.org/articles/10.3389/fphar.2022.853119/fullBrucea javanicachemical constituentspharmacological activitiesmolecular mechanismanti-cancer |
| spellingShingle | Juan Zhang Hong-Xi Xu Yao-Xing Dou Qiong-Hui Huang Yan-Fang Xian Zhi-Xiu Lin Zhi-Xiu Lin Major Constituents From Brucea javanica and Their Pharmacological Actions Frontiers in Pharmacology Brucea javanica chemical constituents pharmacological activities molecular mechanism anti-cancer |
| title | Major Constituents From Brucea javanica and Their Pharmacological Actions |
| title_full | Major Constituents From Brucea javanica and Their Pharmacological Actions |
| title_fullStr | Major Constituents From Brucea javanica and Their Pharmacological Actions |
| title_full_unstemmed | Major Constituents From Brucea javanica and Their Pharmacological Actions |
| title_short | Major Constituents From Brucea javanica and Their Pharmacological Actions |
| title_sort | major constituents from brucea javanica and their pharmacological actions |
| topic | Brucea javanica chemical constituents pharmacological activities molecular mechanism anti-cancer |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.853119/full |
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